Composite mirror facets for ground based gamma ray astronomy

Composite mirrors for gamma-ray astronomy have been developed to fulfill the specifications required for the next generation of Cherenkov telescopes represented by CTA (Cherenkov Telescope Array). In addition to the basic requirements on focus and reflection efficiency, the mirrors have to be stiff, lightweight, durable and cost efficient. In this paper, the technology developed to produce such mirrors is described, as well as some tests that have been performed to validate them. It is shown that these mirrors comply with the needs of CTA, making them good candidates for use on a significant part of the array.Comment: 16 pages, 13 figures, accepted to be published on NIM

Francis Johnson: Music Master of Early Philadelphia

Guthrie P. Ramsey, Jr., Associate Professor of Music, University of Pennsylvania, delivers a lecture on Francis Johnson (1792-1844), Philadelphia band leader and composer. Johnson holds a special place in the history of American music. Although a free African American, he lived in an age when racial segregation and prejudice were commonplace. Despite these obstacles, he was able to achieve extraordinary renown and respect among the elite of Philadelphia through performances of his band at balls, parades, and promenade concerts. Following a series of concert tours late in his life, Johnson\u27s fame eventually extended through the Midwest and across the Atlantic to London. His music survives today in piano arrangements published during his lifetime. The lecture marked the opening of an exhibition in the Otto E. Albrecht Music Library. The exhibition included a selection from the over forty pieces of Johnson sheet music in the collection of the late Kurt Stein. Also part of the exhibition were prints, period newspaper articles, and a Kent bugle like that favored by Johnson. To download a podcast of the lecture, select one of the additional files below. Welcome, H. Carton Rogers, 00-04:52 Introduction, Richard Griscom, 04:52-13:06 Lecture, Guthrie P. Ramsay, Jr., 13:15-37:27 The event announcement is also available for download, by selecting the download button, at upper right. The exhibition is available in an online version, at: https://web.archive.org/web/20160422121347/https://www.library.upenn.edu/exhibits/music/fjohnson

Multiple causes of interannual sea surface temperature variability in the equatorial Atlantic Ocean

The eastern equatorial Atlantic Ocean is subject to interannual fluctuations of sea surface temperatures, with climatic impacts on the surrounding continents. The dynamic mechanism underlying Atlantic temperature variability is thought to be similar to that of the El Nino/Southern Oscillation (ENSO) in the equatorial Pacific, where air-sea coupling leads to a positive feedback between surface winds in the western basin, sea surface temperature in the eastern basin, and equatorial oceanic heat content. Here we use a suite of observational data, climate reanalysis products, and general circulation model simulations to reassess the factors driving the interannual variability. We show that some of the warm events can not be explained by previously identified equatorial wind stress forcing and ENSO-like dynamics. Instead, these events are driven by a mechanism in which surface wind forcing just north of the equator induces warm ocean temperature anomalies that are subsequently advected toward the equator. We find the surface wind patterns are associated with long-lived subtropical sea surface temperature anomalies and suggest they therefore reflect a link between equatorial and subtropical Atlantic variability

Nitrogen Response of Spring and Winter Wheat to Biosolids Compared to Chemical Fertiliser

Irish sewage sludge production was over 30,000 t/year in the 1990s (EPA, Ireland, 2003). Application to agricultural land is a management option for this organic material as it results in the recycling of the nutrients they contain for crop production. The EU Directive (91/271/EEC) encourages the recycling of sewage sludge as biosolids to agriculture. However, up to 1999, only about 5 % of biosolids produced was applied to agricultural land. In this study, several biosolids and a chemical fertiliser were used to assess N availability for spring and winter wheat (Triticum aestivum,) production in a pot experiment

efficacy and safety of ramucirumab ram in asian and non asian patients with advanced hepatocellular carcinoma hcc and elevated alpha fetoprotein afp subgroup analysis from two randomized studies

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First-Order Melting and Dynamics of Flux Lines in a Model for YBa2_2Cu3_3O7−δ_{7-\delta}

We have studied the statics and dynamics of flux lines in a model for YBCO, using both Monte Carlo simulations and Langevin dynamics. For a clean system, both approaches yield the same melting curve, which is found to be weakly first order with a heat of fusion of about $0.02 k_BT_m$ per vortex pancake at a field of $50 {\rm kG}.$ The time averaged magnetic field distribution experienced by a fixed spin is found to undergo a qualitative change at freezing, in agreement with NMR and $\mu {\rm SR}$ experiments. Melting in the clean system is accompanied by a proliferation of free disclinations which show a clear B-dependent 3D-2D crossover from long disclination lines parallel to the c-axis at low fields, to 2D ``pancake'' disclinations at higher fields. Strong point pins produce a logarithmical $\ln t$ relaxation which results from slow annealing out of disclinations in disordered samples.Comment: 31 pages, latex, revtex, 12 figures available upon request, No major changes to the original text, but some errors in the axes scale for Figures 6 and 7 were corrected(new figures available upon request), to be published in Physical Review B, July 199

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2). Our study has defined the origin of these macrophages by showing Gr1+ inflammatory monocytes (IMs) are preferentially recruited to pulmonary metastases but not primary mammary tumors, a process also found for human IMs in pulmonary metastases of human breast cancer cells. The recruitment of these CCR2 (receptor for chemokine CCL2) expressing IMs and subsequently MAMs and their interaction with metastasizing tumor cells is dependent on tumor and stromal synthesized CCL2 (FigS1). Inhibition of CCL2/CCR2 signaling using anti-CCL2 antibodies blocks IM recruitment and inhibits metastasis in vivo and prolongs the survival of tumor-bearing mice. Depletion of tumor cell-derived CCL2 also inhibits metastatic seeding. IMs promote tumor cell extravasation in a process that requires monocyte-derived VEGF. CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer (Fig S2)(3-6). Our data provides the mechanistic link between these two clinical associations and indicates new therapeutic targets for treating metastatic breast disease

Mirror development for the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is a planned observatory for very-high energy gamma-ray astronomy. It will consist of several tens of telescopes of different sizes, with a total mirror area of up to 10,000 square meters. Most mirrors of current installations are either polished glass mirrors or diamond-turned aluminium mirrors, both labour intensive technologies. For CTA, several new technologies for a fast and cost-efficient production of light-weight and reliable mirror substrates have been developed and industrial pre-production has started for most of them. In addition, new or improved aluminium-based and dielectric surface coatings have been developed to increase the reflectance over the lifetime of the mirrors compared to those of current Cherenkov telescope instruments.Fil: Forster, A.. Max-Planck-Institut fur Kernphysik; AlemaniaFil: Armstrong, T.. Durham University; Reino UnidoFil: Baba, H.. Ibaraki University; JapónFil: Bähr, J.. No especifíca;Fil: Bonardi, A.. Universitat Tübingen; AlemaniaFil: Bonnoli, G.. Osservatorio Astronomico di Brera; ItaliaFil: Brun, P.. No especifíca;Fil: Canestrari, R.. Osservatorio Astronomico di Brera; ItaliaFil: Chadwick, P.. Durham University; Reino UnidoFil: Chikawa, M.. University of Tokyo; JapónFil: Carton, P.-H.. Centre de Saclay; FranciaFil: De Souza, V.. Universidade de Sao Paulo; BrasilFil: Dipold, J.. Universidade de Sao Paulo; BrasilFil: Doro, M.. Università di Padova; ItaliaFil: Durand, D.. No especifíca;Fil: Dyrda, M.. Polish Academy of Sciences; ArgentinaFil: Giro, E.. Osservatorio Astronomico di Padova; ItaliaFil: Glicenstein, J.-F.. No especifíca;Fil: Hanabata, Y.. Kinki University; JapónFil: Hayashida, M.. University of Tokyo; JapónFil: Hrabovski, M.. No especifíca;Fil: Jeanney, C.. Centre de Saclay; FranciaFil: Kagaya, M.. Ibaraki University; JapónFil: Katagiri, H.. Ibaraki University; JapónFil: Lessio, L.. Osservatorio Astronomico di Padova; ItaliaFil: Mandat, D.. Institute of Physics of the Academy of Sciences of the Czech Republic; República ChecaFil: Mariotti, M.. Università di Padova; ItaliaFil: Medina, Maria Clementina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Yoshida, T.. Ibaraki University; Japón33rd International Cosmic Ray ConferenceRío de JaneiroBrasilBrazilian Physical Societ