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Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.
Complement receptor type 2 (CR2;CD21), a member of the superfamily of proteins containing short consensus repeats (SCRs), is the B cell receptor for both the gp350/220 envelope protein of Epstein-Barr virus (EBV), and for the C3dg protein of complement. By analysis of CR2 deletion mutants and chimeras formed with CR1 (CD35) we determined that of the 15 SCRs in CR2, the NH2-terminal two SCRs are necessary and sufficient to bind both gp350/220 and C3dg with affinities equivalent to those of the wild-type receptor. The epitope for OKB-7, a mAb that blocks binding of both EBV and C3dg and shares with these ligands B cell-activating capabilities, also requires both SCR-1 and SCR-2, whereas mAbs lacking these functions bind to other SCRs. Thus, EBV, a polyclonal activator of B cells, has selected a site that is proximate or identical to the natural ligand binding site in CR2, perhaps reflecting the relative immutability of that site as well as its signal transducing function
Circumstellar environment of RX Puppis
The symbiotic Mira, RX Pup, shows long-term variations in its mean light
level due to variable obscuration by circumstellar dust. The last increase in
extinction towards the Mira, between 1995 and 2000, has been accompanied by
large changes in the degree of polarization in the optical and red spectral
range. The lack of any obvious associated changes in the position angle may
indicate the polarization variations are driven by changes in the properties of
the dust grains (e.g. variable quantity of dust and variable particle size
distribution, due to dust grain formation and growth) rather than changes in
the viewing geometry of the scattering region(s), e.g. due to the binary
rotation.Comment: Paper presented at Torun 2000 conference on Post-AGB objects as a
phase of stellar evolution; 8 pages, 3 figure
A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer
PMH15 BURDEN OF ILLNESS AMONG PATIENTS WITH ALZHEIMER'S DISEASE IN A COMMERCIALLY-INSURED POPULATION
Substorm Onset Latitude and the Steadiness of Magnetospheric Convection
We study the role of substorms and steady magnetospheric convection (SMC) in magnetic flux transport in the magnetosphere, using observations of fieldâaligned currents by the Active Magnetosphere and Planetary Electrodynamics Response Experiment. We identify two classes of substorm, with onsets above and below 65° magnetic latitude, which display different nightside fieldâaligned current morphologies. We show that the lowâlatitude onsets develop a polewardâexpanding auroral bulge, and identify these as substorms that manifest ionospheric convectionâbraking in the auroral bulge region as suggested by Grocott et al. (2009, https://doi.org/10.5194/angeo-27-591-2009). We show that the highâlatitude substorms, which do not experience braking, can evolve into SMC events if the interplanetary magnetic field remains southward for a prolonged period following onset. We conclude that during periods of ongoing driving, the magnetosphere displays repeated substorm activity or SMC depending on the rate of driving and the open magnetic flux content of the magnetosphere prior to onset. We speculate that sawtooth events are an extreme case of repeated onsets and that substorms triggered by northwardâturnings of the interplanetary magnetic field mark the cessation of periods of SMC. Our results provide a new explanation for the differing modes of response of the terrestrial system to solar windâmagnetosphereâionosphere coupling by invoking friction between the ionosphere and atmosphere.publishedVersio
Generalized Painleve-Gullstrand descriptions of Kerr-Newman black holes
Generalized Painleve-Gullstrand metrics are explicitly constructed for the
Kerr-Newman family of charged rotating black holes. These descriptions are free
of all coordinate singularities; moreover, unlike the Doran and other proposed
metrics, an extra tunable function is introduced to ensure all variables in the
metrics remain real for all values of the mass M, charge Q, angular momentum
aM, and cosmological constant \Lambda > - 3/(a^2). To describe fermions in
Kerr-Newman spacetimes, the stronger requirement of non-singular vierbein
one-forms at the horizon(s) is imposed and coordinate singularities are
eliminated by local Lorentz boosts. Other known vierbein fields of Kerr-Newman
black holes are analysed and discussed; and it is revealed that some of these
descriptions are actually not related by physical Lorentz transformations to
the original Kerr-Newman expression in Boyer-Lindquist coordinates - which is
the reason complex components appear (for certain ranges of the radial
coordinate) in these metrics. As an application of our constructions the
correct effective Hawking temperature for Kerr black holes is derived with the
method of Parikh and Wilczek.Comment: 5 pages; extended to include application to derivation of Hawking
radiation for Kerr black holes with Parikh-Wilczek metho
Sosa on Knowledge, Judgment and Guessing
In Chapter 3 of Judgment and Agency, Sosa (Judgment and Agency, 2015) explicates the concept of a fully apt performance. In the course of doing so, he draws from illustrative examples of practical performances and applies lessons drawn to the case of cognitive performances, and in particular, to the cognitive performance of judging. Sosaâs examples in the practical sphere are rich and instructive. But there is, I will argue, an interesting disanalogy between the practical and cognitive examples he relies on. Ultimately, I think the source of the disanalogy is a problematic picture of the cognitive performance of guessing and its connection to knowledge and defeat. Once this critical line of argument is advanced, an alternative picture of guessing, qua cognitive performance, is articulated, one which avoids the problems discussed, and yet remains compatible with Sosaâs broader framework
Bayesian Methods for Exoplanet Science
Exoplanet research is carried out at the limits of the capabilities of
current telescopes and instruments. The studied signals are weak, and often
embedded in complex systematics from instrumental, telluric, and astrophysical
sources. Combining repeated observations of periodic events, simultaneous
observations with multiple telescopes, different observation techniques, and
existing information from theory and prior research can help to disentangle the
systematics from the planetary signals, and offers synergistic advantages over
analysing observations separately. Bayesian inference provides a
self-consistent statistical framework that addresses both the necessity for
complex systematics models, and the need to combine prior information and
heterogeneous observations. This chapter offers a brief introduction to
Bayesian inference in the context of exoplanet research, with focus on time
series analysis, and finishes with an overview of a set of freely available
programming libraries.Comment: Invited revie
Elgin on understanding:How does it involve know-how, endorsement and factivity?
In Chapter 3 of True Enough, Elgin (2017) outlines her view of objectual understanding, focusing largely on its non-factive nature and the extent to which a certain kind of know-how is required for the âgraspingâ component of understanding. I will explore four central issues that feature in this chapter, concentrating on (1) the role of know-how, (2) the concept of endorsement, (3) Elginâs critique of the factivity constraint on understanding, and (4) how we might use aspects of Elginâs framework to inform related debates on the norm of assertion
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