Monetary Policy, Efficiency Wages, and Nominal Wage Rigidities

Monetary policy can lower unemployment and have other real effects when efficiency wages are combined with some nominal rigidity. In some models, the rigidity causes a fixed nominal wage. Thus a monetary expansion that raises prices must lower real wages; this can raise employment and output. But one might conclude that at least in their current forms, efficiency wage models with nominal wage rigidities cannot be plausibly applied to monetary issues or used to justify monetary policy. With such rigidities, a monetary expansion lowers real wages, raises employment, and lowers efficiency. This paper uses a general efficiency wage model to reanalyze the effects of monetary policy. Here, a rise in the money supply raises employment but lowers output. This happens because efficiency or productivity falls when the money supply rises. The conclusion to be drawn is not that monetary expansions really are contractionary. Instead, one might conclude that, at least in their current forms, efficiency wage models with nominal wage rigidities may not be well-suited to discussions of monetary policy. Alternative models may be more useful.

Quasiequilibrium sequences of black-hole--neutron-star binaries in general relativity

We construct quasiequilibrium sequences of black hole-neutron star binaries for arbitrary mass ratios by solving the constraint equations of general relativity in the conformal thin-sandwich decomposition. We model the neutron star as a stationary polytrope satisfying the relativistic equations of hydrodynamics, and account for the black hole by imposing equilibrium boundary conditions on the surface of an excised sphere (the apparent horizon). In this paper we focus on irrotational configurations, meaning that both the neutron star and the black hole are approximately nonspinning in an inertial frame. We present results for a binary with polytropic index n=1, mass ratio M_{irr}^{BH}/M_{B}^{NS}=5 and neutron star compaction M_{ADM,0}^{NS}/R_0=0.0879, where M_{irr}^{BH} is the irreducible mass of the black hole, M_{B}^{NS} the neutron star baryon rest-mass, and M_{ADM,0}^{NS} and R_0 the neutron star Arnowitt-Deser-Misner mass and areal radius in isolation, respectively. Our models represent valid solutions to Einstein's constraint equations and may therefore be employed as initial data for dynamical simulations of black hole-neutron star binaries.Comment: 5 pages, 1 figure, revtex4, published in Phys.Rev.

Designing Improved Sediment Transport Visualizations

Monitoring, or more commonly, modeling of sediment transport in the coastal environment is a critical task with relevance to coastline stability, beach erosion, tracking environmental contaminants, and safety of navigation. Increased intensity and regularity of storms such as Superstorm Sandy heighten the importance of our understanding of sediment transport processes. A weakness of current modeling capabilities is the ability to easily visualize the result in an intuitive manner. Many of the available visualization software packages display only a single variable at once, usually as a two-dimensional, plan-view cross-section. With such limited display capabilities, sophisticated 3D models are undermined in both the interpretation of results and dissemination of information to the public. Here we explore a subset of existing modeling capabilities (specifically, modeling scour around man-made structures) and visualization solutions, examine their shortcomings and present a design for a 4D visualization for sediment transport studies that is based on perceptually-focused data visualization research and recent and ongoing developments in multivariate displays. Vector and scalar fields are co-displayed, yet kept independently identifiable utilizing human perception\u27s separation of color, texture, and motion. Bathymetry, sediment grain-size distribution, and forcing hydrodynamics are a subset of the variables investigated for simultaneous representation. Direct interaction with field data is tested to support rapid validation of sediment transport model results. Our goal is a tight integration of both simulated data and real world observations to support analysis and simulation of the impact of major sediment transport events such as hurricanes. We unite modeled results and field observations within a geodatabase designed as an application schema of the Arc Marine Data Model. Our real-world focus is on the Redbird Artificial Reef Site, roughly 18 nautical miles offshor- Delaware Bay, Delaware, where repeated surveys have identified active scour and bedform migration in 27 m water depth amongst the more than 900 deliberately sunken subway cars and vessels. Coincidently collected high-resolution multibeam bathymetry, backscatter, and side-scan sonar data from surface and autonomous underwater vehicle (AUV) systems along with complementary sub-bottom, grab sample, bottom imagery, and wave and current (via ADCP) datasets provide the basis for analysis. This site is particularly attractive due to overlap with the Delaware Bay Operational Forecast System (DBOFS), a model that provides historical and forecast oceanographic data that can be tested in hindcast against significant changes observed at the site during Superstorm Sandy and in predicting future changes through small-scale modeling around the individual reef objects

The human myometrium differentially expresses mTOR signalling components before and during pregnancy: Evidence for regulation by progesterone

Emerging studies implicate the signalling of the mammalian target of rapamycin (mTOR) in a number of reproductive functions. To this date, there are no data regarding the expression of mTOR signalling components in the human myometrium during pregnancy. We hypothesized that mTOR-related genes might be differentially expressed in term or preterm labour as well as in labour or non-labour myometria during pregnancy. Using quantitative RT-PCR we demonstrate for first time that there is a significant downregulation of mTOR, DEPTOR, and Raptor in preterm labouring myometria when compared to non-pregnant tissues taken from the same area (lower segment). We used an immortalized myometrial cell line (ULTR) as an in vitro model to dissect further mTOR signalling. In ULTR cells DEPTOR and Rictor had a cytoplasmic distribution, whereas mTOR and Raptor were detected in the cytoplasm and the nucleus, indicative of mTORC1 shuttling. Treatment with inflammatory cytokines caused only minor changes in gene expression of these components, whereas progesterone caused significant down-regulation. We performed a non-biased gene expression analysis of ULTR cells using Nimblegen human gene expression microarray (n = 3), and selected genes were validated by quantitative RT-PCR in progesterone treated myometrial cells. Progesterone significantly down-regulated key components of the mTOR pathway. We conclude that the human myometrium differentially expresses mTOR signalling components and they can be regulated by progesterone. This article is part of a Special Issue entitled 'Pregnancy and Steroids'.This research was funded by National Institutes of Health Grant ESO12961

An Economic Evaluation of Venous Thromboembolism Prophylaxis Strategies in Critically Ill Trauma Patients at Risk of Bleeding

Using decision analysis, Henry Stelfox and colleagues estimate the cost-effectiveness of three venous thromboembolism prophylaxis strategies in patients with severe traumatic injuries who were also at risk for bleeding complications

On wormholes with arbitrarily small quantities of exotic matter

Recently several models of traversable wormholes have been proposed which require only arbitrarily small amounts of negative energy to hold them open against self-collapse. If the exotic matter is assumed to be provided by quantum fields, then quantum inequalities can be used to place constraints on the negative energy densities required. In this paper, we introduce an alternative method for obtaining constraints on wormhole geometries, using a recently derived quantum inequality bound on the null-contracted stress-energy averaged over a timelike worldline. The bound allows us to perform a simplified analysis of general wormhole models, not just those with small quantities of exotic matter. We then use it to study, in particular, the models of Visser, Kar, and Dadhich (VKD) and the models of Kuhfittig. The VKD models are constrained to be either submicroscopic or to have a large discrepancy between throat size and curvature radius. A recent model of Kuhfittig is shown to be non-traversable. This is due to the fact that the throat of his wormhole flares outward so slowly that light rays and particles, starting from outside the throat, require an infinite lapse of affine parameter to reach the throat.Comment: 30 pages, 2 figure

Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo

Members of the tripartite motif (TRIM) protein family have been shown to assemble into structures in both the nucleus and cytoplasm. One TRIM protein family member, TRIM5α, has been shown to form cytoplasmic bodies involved in restricting retroviruses such as HIV-1. Here we applied cryogenic correlated light and electron microscopy, combined with electron cryo-tomography, to intact mammalian cells expressing YFP-rhTRIM5α and found the presence of hexagonal nets whose arm lengths were similar to those of the hexagonal nets formed by purified TRIM5α in vitro. We also observed YFP-rhTRIM5α within a diversity of structures with characteristics expected for organelles involved in different stages of macroautophagy, including disorganized protein aggregations (sequestosomes), sequestosomes flanked by flat double-membraned vesicles (sequestosome:phagophore complexes), sequestosomes within double-membraned vesicles (autophagosomes), and sequestosomes within multivesicular autophagic vacuoles (amphisomes or autolysosomes). Vaults were also seen in these structures, consistent with their role in autophagy. Our data 1) support recent reports that TRIM5α can form both well-organized signaling complexes and nonsignaling aggregates, 2) offer images of the macroautophagy pathway in a near-native state, and 3) reveal that vaults arrive early in macroautophagy