Can we promote plural local pathways to sustainable development? Insights from the implementation of Wales’s Future Generations Act

This paper examines the implementation of the Well-being of Future Generations (Wales) Act 2015, the first and only piece of legislation to codify the United Nation’s Sustainable Development Goals in law. The paper provides empirical analysis of the implementation of this legislation based on 16 semi-structured interviews with stakeholders across Wales. The analysis explores whether the Act can deliver spatial justice in Wales through its novel and place-based approach to sustainable development. We examine how the Act has been implemented at different spatial scales–the local, the regional and the national–and how the differences in the way it is interpreted by actors at these different levels influences the extent to which spatial justice is realised in its implementation

Political views and science literacy as indicators of vaccine confidence and COVID-19 concern

Introduction The distrust, delay and refusal of vaccinations represent serious threats to global public health. As demonstrated by the dramatic worldwide impact of the COVID-19 pandemic, adequate vaccine coverage against infectious diseases is essential towards the preservation and function of virtually every aspect of our society. While the determinants of vaccine hesitancy and pandemic concern have been widely investigated, conflicting evidence exists with regards to their association with education levels and political views. Methods This study aimed to investigate whether science literacy levels and standpoint on social and economic matters are associated with different levels of vaccine confidence and COVID-19 concern. An online survey was circulated amongst participants recruited via convenience sampling, and data were analysed using non-parametric statistical tests. Results The survey (n = 389) highlighted that participants who studied Science at General Certificate of Secondary Education level have a lower vaccine confidence than those with both lower and higher levels of science education. Participants with neutral/centrist political views expressed lower confidence than those with a libertarian social stance or a left-wing economic stance. A higher concern with the COVID-19 pandemic was associated with lower levels of science education, libertarian social views, and left-wing economic views. Conclusions The present study provides novel insight on the educational and political factors associated with vaccine hesitancy and pandemic concern within a British population sample

Youth, race and the inner-city estate: narratives of everyday life in Manchester's Hulme, 1970–1994

Since the 1970s, policy-makers and the press have rendered young people, particularly those of black and minority ethnic backgrounds, synonymous with ‘inner-city crisis’. Focusing upon the high-density, multi-storey Hulme estate in Manchester, this article seeks to transcend stereotypical representations of these residents and illuminate their perspectives of the inner city. Conceptualizing the inner city as both a discursive and lived space, the article traces the intersections between its representation and residents’ testimonies to assess how far residents used prevalent understandings of Hulme as a space of crime and social breakdown respectively to shape their narratives of everyday life

Ecological Consequences of Shoreline Hardening: A Meta-Analysis

Protecting coastal communities has become increasingly important as their populations grow, resulting in increased demand for engineered shore protection and hardening of over 50% of many urban shorelines. Shoreline hardening is recognized to reduce ecosystem services that coastal populations rely on, but the amount of hardened coastline continues to grow in many ecologically important coastal regions. Therefore, to inform future management decisions, we conducted a meta-analysis of studies comparing the ecosystem services of biodiversity (richness or diversity) and habitat provisioning (organism abundance) along shorelines with versus without engineered-shore structures. Seawalls supported 23% lower biodiversity and 45% fewer organisms than natural shorelines. In contrast, biodiversity and abundance supported by riprap or breakwater shorelines were not different from natural shorelines; however, effect sizes were highly heterogeneous across organism groups and studies. As coastal development increases, the type and location of shoreline hardening could greatly affect the habitat value and functioning of nearshore ecosystems

Observable signatures of wind-driven chemistry with a fully consistent three dimensional radiative hydrodynamics model of HD 209458b (dataset)

rt_u-as329 - tracer experimentrt_u-as361 - transmission - equilibriumrt_u-as298 - transmission -relaxationrt_u-ar698 - emission - equilibriumrt_u-ar697 - emission - relaxationrt_u-ar586 - relaxationrt_u-ar412 - equilibriumtf_u-ar475 - start from spun up windstf_u-ar354 - resolution 96X60X33 start from spun up windstf_u-ar333 - resolution 72X45X33 start from spun up windstf_u-aq931 - timescale x 1e-8tf_u-aq930 - timescale x 1e-4tf_u-aq815 - resolution 72X45X33tf_u-aq814 - resolution 96X60X33tf-u-aq801 - chemical equilibriumtf_u-aq557 - standard Cooper and Showman 2006tf_u-aq800 - Initialise all carbon in COThe data contained in this submission is associated with the publication Drummond et al, ApJL, 2018.The article associated with this dataset is located in ORE at: http://hdl.handle.net/10871/31897We present a study of the effect of wind-driven advection on the chemical composition of hot Jupiter atmospheres using a fully-consistent 3D hydrodynamics, chemistry and radiative transfer code, the Met Office Unified Model (UM). Chemical modelling of exoplanet atmospheres has primarily been restricted to 1D models that cannot account for 3D dynamical processes. In this work we couple a chemical relaxation scheme to the UM to account for the chemical interconversion of methane and carbon monoxide. This is done consistently with the radiative transfer meaning that departures from chemical equilibrium are included in the heating rates (and emission) and hence complete the feedback between the dynamics, thermal structure and chemical composition. In this letter we simulate the well studied atmosphere of HD 209458b. We find that the combined effect of horizontal and vertical advection leads to an increase in the methane abundance by several orders of magnitude; directly opposite to the trend found in previous works. Our results demonstrate the need to include 3D effects when considering the chemistry of hot Jupiter atmospheres. We calculate transmission and emission spectra, as well as the emission phase curve, from our simulations. We conclude that gas-phase non-equilibrium chemistry is unlikely to explain the model–observation discrepancy in the 4.5 μm Spitzer/IRAC channel. However, we highlight other spectral regions, observable with the James Webb Space Telescope, where signatures of wind-driven chemistry are more prominant.BD and DKS acknowledge funding from the European Research Council (ERC) under the European Unions Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement no. 336792. NJM is part funded by a Leverhulme Trust Research Project Grant. JM and IAB acknowledge the support of a Met Office Academic Partnership secondment. ALC is funded by an STFC studentship. DSA acknowledges support from the NASA Astrobiology Program through the Nexus for Exoplanet System Science. This work used the DiRAC Complexity system, operated by the University of Leicester IT Services, which forms part of the STFC DiRAC HPC Facility. This equipment is funded by BIS National E-Infrastructure capital grant ST/K000373/1 and STFC DiRAC Operations grant ST/K0003259/1. DiRAC is part of the National E-Infrastructure

Site-Specific Integration and Expression of an Anti-Malarial Gene in Transgenic Anopheles gambiae Significantly Reduces Plasmodium Infections

Diseases transmitted by mosquitoes have a devastating impact on global health and this is worsening due to difficulties with existing control measures and climate change. Genetically modified mosquitoes that are refractory to disease transmission are seen as having great potential in the delivery of novel control strategies. Historically the genetic modification of insects has relied upon transposable elements which have many limitations despite their successful use. To circumvent these limitations the Streptomyces phage phiC31 integrase system has been successfully adapted for site-specific transgene integration in insects. Here, we present the first site-specific transformation of Anopheles gambiae, the principal vector of human malaria. Mosquitoes were initially engineered to incorporate the phiC31 targeting site at a defined genomic location. A second phase of genetic modification then achieved site-specific integration of Vida3, a synthetic anti-malarial gene. Expression of Vida3, specifically in the midgut of bloodfed females, offered consistent and significant protection against Plasmodium yoelii nigeriensis, reducing average parasite intensity by 85%. Similar protection was observed against Plasmodium falciparum in some experiments, although protection was inconsistent. In the fight against malaria, it is imperative to establish a broad repertoire of both anti-malarial effector genes and tissue-specific promoters for their expression, enabling those offering maximum effect with minimum fitness cost to be identified. In the future, this technology will allow effective comparisons and informed choices to be made, potentially leading to complete transmission blockade

A Randomized Trial Assessing the Safety and Immunogenicity of AS01 and AS02 Adjuvanted RTS,S Malaria Vaccine Candidates in Children in Gabon

Background:The malaria vaccine candidate antigen RTS,S includes parts of the pre-erythrocytic stage circumsporozoite protein fused to the Hepatitis B surface antigen. Two Adjuvant Systems are in development for this vaccine, an oil-in water emulsion – based formulation (AS02) and a formulation based on liposomes (AS01).Methods & Principal Findings:In this Phase II, double-blind study (NCT00307021), 180 healthy Gabonese children aged 18 months to 4 years were randomized to receive either RTS,S/AS01E or RTS,S/AS02D, on a 0–1–2 month vaccination schedule. The children were followed-up daily for six days after each vaccination and monthly for 14 months. Blood samples were collected at 4 time-points. Both vaccines were well tolerated. Safety parameters were distributed similarly between the two groups. Both vaccines elicited a strong specific immune response after Doses 2 and 3 with a ratio of anti-CS GMT titers (AS02D/AS01E) of 0.88 (95% CI: 0.68–1.15) post-Dose 3. After Doses 2 and 3 of experimental vaccines, anti-CS and anti-HBs antibody GMTs were higher in children who had been previously vaccinated with at least one dose of hepatitis B vaccine compared to those not previously vaccinated.Conclusions:RTS,S/AS01E proved similarly as well tolerated and immunogenic as RTS,S/AS02D, completing an essential step in the age de-escalation process within the RTS,S clinical development plan