An intelligent allocation algorithm for parallel processing

The problem of allocating nodes of a program graph to processors in a parallel processing architecture is considered. The algorithm is based on critical path analysis, some allocation heuristics, and the execution granularity of nodes in a program graph. These factors, and the structure of interprocessor communication network, influence the allocation. To achieve realistic estimations of the executive durations of allocations, the algorithm considers the fact that nodes in a program graph have to communicate through varying numbers of tokens. Coarse and fine granularities have been implemented, with interprocessor token-communication duration, varying from zero up to values comparable to the execution durations of individual nodes. The effect on allocation of communication network structures is demonstrated by performing allocations for crossbar (non-blocking) and star (blocking) networks. The algorithm assumes the availability of as many processors as it needs for the optimal allocation of any program graph. Hence, the focus of allocation has been on varying token-communication durations rather than varying the number of processors. The algorithm always utilizes as many processors as necessary for the optimal allocation of any program graph, depending upon granularity and characteristics of the interprocessor communication network

Psychological stress and cardiovascular disease: empirical demonstration of bias in a prospective observational study of Scottish men

Objectives: To examine the association between self perceived psychological stress and cardiovascular disease in a population where stress was not associated with social disadvantage. Design: Prospective observational study with follow up of 21 years and repeat screening of half the cohort 5 years from baseline. Measures included perceived psychological stress, coronary risk factors, self reported angina, and ischaemia detected by electrocardiography. Setting: 27 workplaces in Scotland. Participants: 5606 men (mean age 48 years) at first screening and 2623 men at second screening with complete data on all measures Main outcome measures: Prevalence of angina and ischaemia at baseline, odds ratio for incident angina and ischaemia at second screening, rate ratios for cause specific hospital admission, and hazard ratios for cause specific mortality. Results: Both prevalence and incidence of angina increased with increasing perceived stress (fully adjusted odds ratio for incident angina, high versus low stress 2.66, 95% confidence interval 1.61 to 4.41; P for trend <0.001). Prevalence and incidence of ischaemia showed weak trends in the opposite direction. High stress was associated with a higher rate of admissions to hospital generally and for admissions related to cardiovascular disease and psychiatric disorders (fully adjusted rate ratios for any general hospital admission 1.13, 1.01 to 1.27, cardiovascular disease 1.20, 1.00 to 1.45, and psychiatric disorders 2.34, 1.41 to 3.91). High stress was not associated with increased admission for coronary heart disease (1.00, 0.76-1.32) and showed an inverse relation with all cause mortality, mortality from cardiovascular disease, and mortality from coronary heart disease, that was attenuated by adjustment for occupational class (fully adjusted hazard ratio for all cause mortality 0.94, 0.81 to 1.11, cardiovascular mortality 0.91, 0.78 to 1.06, and mortality from coronary heart disease 0.98, 0.75 to 1.27). Conclusions: The relation between higher stress, angina, and some categories of hospital admissions probably resulted from the tendency of participants reporting higher stress to also report more symptoms. The lack of a corresponding relation with objective indices of heart disease suggests that these symptoms did not reflect physical disease. The data suggest that associations between psychosocial measures and disease outcomes reported from some other studies may be spurious

Limitations of adjustment for reporting tendency in observational studies of stress and self reported coronary heart disease

Recently, observational evidence has been suggested to show a causal association between various "psychosocial" exposures, including psychological stress, and heart disease. Much of this evidence derives from studies in which a self reported psychosocial exposure is related to an outcome dependent on the subjective experience of coronary heart disease (CHD) symptoms. Such outcomes may be measured using standard symptom questionnaires (like the Rose angina schedule). Alternatively they may use diagnoses of disease from medical records, which depend on an individual perceiving symptoms and reporting them to a health worker. In these situations, reporting bias may generate spurious exposure-outcome associations. For example if people who perceive and report their life as most stressful also over-report symptoms of cardiovascular disease then an artefactual association between stress and heart disease will result

Topological Quintessence

A global monopole (or other topological defect) formed during a recent phase transition with core size comparable to the present Hubble scale, could induce the observed accelerating expansion of the universe. In such a model, topological considerations trap the scalar field close to a local maximum of its potential in a cosmologically large region of space. We perform detailed numerical simulations of such an inhomogeneous dark energy system (topological quintessence) minimally coupled to gravity, in a flat background of initially homogeneous matter. We find that when the energy density of the field in the monopole core starts dominating the background density, the spacetime in the core starts to accelerate its expansion in accordance to a \Lambda CDM model with an effective inhomogeneous spherical dark energy density parameter \Omega_\Lambda(r). The matter density profile is found to respond to the global monopole profile via an anti-correlation (matter underdensity in the monopole core). Away from the monopole core, the spacetime is effectively Einstein-deSitter (\Omega_\Lambda(r_{out}) -> 0) while at the center \Omega_\Lambda(r ~ 0) is maximum. We fit the numerically obtained expansion rate at the monopole core to the Union2 data and show that the quality of fit is almost identical to that of \Lambda CDM. Finally, we discuss potential observational signatures of this class of inhomogeneous dark energy models.Comment: Accepted in Phys. Rev. D (to appear). Added observational bounds on parameters. 10 pages (two column revtex), 6 figures. The Mathematica files used to produce the figures of this study may be downloaded from http://leandros.physics.uoi.gr/topquin

Use of multiple singular value decompositions to analyze complex intracellular calcium ion signals

We compare calcium ion signaling ($\mathrm {Ca}^{2+}$) between two exposures; the data are present as movies, or, more prosaically, time series of images. This paper describes novel uses of singular value decompositions (SVD) and weighted versions of them (WSVD) to extract the signals from such movies, in a way that is semi-automatic and tuned closely to the actual data and their many complexities. These complexities include the following. First, the images themselves are of no interest: all interest focuses on the behavior of individual cells across time, and thus, the cells need to be segmented in an automated manner. Second, the cells themselves have 100$+$ pixels, so that they form 100$+$ curves measured over time, so that data compression is required to extract the features of these curves. Third, some of the pixels in some of the cells are subject to image saturation due to bit depth limits, and this saturation needs to be accounted for if one is to normalize the images in a reasonably unbiased manner. Finally, the $\mathrm {Ca}^{2+}$ signals have oscillations or waves that vary with time and these signals need to be extracted. Thus, our aim is to show how to use multiple weighted and standard singular value decompositions to detect, extract and clarify the $\mathrm {Ca}^{2+}$ signals. Our signal extraction methods then lead to simple although finely focused statistical methods to compare $\mathrm {Ca}^{2+}$ signals across experimental conditions.Comment: Published in at http://dx.doi.org/10.1214/09-AOAS253 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Solitary and compact-like shear waves in the bulk of solids

We show that a model proposed by Rubin, Rosenau, and Gottlieb [J. Appl. Phys. 77 (1995) 4054], for dispersion caused by an inherent material characteristic length, belongs to the class of simple materials. Therefore, it is possible to generalize the idea of Rubin, Rosenau, and Gottlieb to include a wide range of material models, from nonlinear elasticity to turbulence. Using this insight, we are able to fine-tune nonlinear and dispersive effects in the theory of nonlinear elasticity in order to generate pulse solitary waves and also bulk travelling waves with compact support

Gott time machines in the Anti-de Sitter space

In 1991 Gott presented a solution of Einstein's field equations in 2+1 dimensions with $\Lambda = 0$ that contained closed timelike curves (CTC's). This solution was remarkable because at first it did not seem to be unphysical in any other respect. Later, however, it was shown that Gott's solution is tachyonic in a certain sense. Here the case $\Lambda < 0$ is discussed. We show that it is possible to construct CTC's also in this case, in a way analogous to that used by Gott. We also show that this construction still is tachyonic. $\Lambda < 0$ means that we are dealing with Anti-de Sitter space, and since the CTC-construction necessitates some understanding of its structure, a few pages are devoted to this subject.Comment: 11 page

Domain Wall Junctions are 1/4-BPS States

We study N=1 SUSY theories in four dimensions with multiple discrete vacua, which admit solitonic solutions describing segments of domain walls meeting at one-dimensional junctions. We show that there exist solutions preserving one quarter of the underlying supersymmetry -- a single Hermitian supercharge. We derive a BPS bound for the masses of these solutions and construct a solution explicitly in a special case. The relevance to the confining phase of N=1 SUSY Yang-Mills and the M-theory/SYM relationship is discussed.Comment: 18 pages, 4 figures, uses RevTeX. Brief comments concerning lattices of junctions added. Version to appear in Phys. Rev.

Cellular and mucosal immune reactions to mental and cold stress: Associations with gender and cardiovascular reactivity

To examine gender differences in immune reactions to stress and relationships between immune and cardiovascular reactivity, measures of cellular and mucosal immunity and cardiovascular activity were recorded in 77 men and 78 women at rest and in response to active (mental arithmetic) and passive (cold pressor) stress tasks. Both tasks reduced CD4+ T cells and the CD4/8 ratio. Total lymphocytes, NK cells, CD8+ T cells, and secretory immunoglobulin A (sIgA) increased with active stress. Passive stress decreased sIgA. At rest, men had more NK cells, less CD4+ T cells, and fewer neutrophils than women. Mental stress increased sIgA in men but not women. Cardiovascular reactivity to active stress was associated with increases in NK cells. The data support the hypothesis that stress-related increases in lymphocytes are beta-adrenergically mediated, and suggest that the fall in CD4+ T cells may be alpha-adrenergically driven. Mechanisms underlying sIgA reactions are more difficult to determine. Men and women differed in some cell counts, but not in reactivity, although gender influenced sIgA reactions to arithmetic