Psoriatic Pseudobalanitis Circinata as a Post-Viral Koebner Phenomenon

In the absence of any other lesions on the body, the diagnosis of localized genital psoriasis can be difficult, requiring further examinations including a biopsy. We report a case of psoriatic pseudobalanitis circinata triggered by a herpes virus infection, and we discuss the Koebner phenomenon and the therapeutic management of psoriasis of the genital area

Experimental analysis of cold sprayed precursors for closed-cells aluminum foams

Metal foams are a relatively new class of materials with many interesting combinations of physical and mechanical properties. Among them, the closed-cells aluminum foams are the most interesting for structural applications in the aerospace industry. There exist different methods to produce metal foams. An innovative manufacturing technique was developed in this study, proving the possibility to produce closed-cells aluminum foams through the cold spray additive manufacturing technology (CS). In particular, two different sets of samples were produced by varying the cold spray process parameters aiming at: i) studying the advantages and the issues of cold spray for manufacturing precursors for metal foams; ii) analyzing the correlation among the CS printing strategy and parameters, the foaming process and the physical and the morphological characteristics of the resulting foams; iii) finally, finding appropriate conditions to form closed-cells aluminum foams via CS

LONG TIME COLD SPRAY DEPOSITION: EXPERIMENTAL INVESTIGATIONS AND NUMERICAL APPROACH

Low Pressure Cold Spray process is a relatively new coating technique which allows to create high quality metallic coatings, on both metallic and non-metallic substrates, without extensive heating of the powders sprayed. Upon impact with a target surface, conversion of kinetic energy to plastic deformation occurs, the solid particles deform and bond together. To date, the complex adhesion mechanisms of the particles are still being discussed and, what is more, the phenomena occurring during the long time deposition processes, the most interesting ones for industrial applications, are not adequately studied and known. The aim of this paper is to contribute to fill this lack of knowledge through the detailed analysis of the phenomena occurring during long time depositions. To this end a full experimental campaign was carried out. Moreover it was also proposed a numerical model focusing on both geometrical features and fluid-dynamic behaviour of converging-diverging de- Laval nozzle system. Micron-sized aluminium powders and compressed air as carrier gas were used in this experimentation. It has been found that the deposition efficiency tends to decrease due to the critical phenomena occur into the spray nozzle during long time depositions. The sprayed particles tend to stick to the walls of the nozzle and, moreover, a shock wave occurs inside the nozzle further promoting the particles stick phenomena, making the system inefficient

Experimental study and numerical investigation of the phenomena occurring during long duration cold spray deposition

Low Pressure Cold Spray process is a relatively new additive technique allowing to create high quality metallic coatings, through the high velocity spraying of particles, on both metallic and non-metallic substrates. The adhesion mechanism of the particles is, to date, not fully understood and the phenomena occurring during long depositions (which are the more interesting for industrial processes) are not known and studied in details. Aiming to fulfill this lack of knowledge, the phenomena occurring during long deposition were studied through both careful experimental evaluations and numerical approach. Particular attention was paid at the working conditions of the De Laval nozzle system which accelerates the particles, a computational fluid dynamics model focusing on both geometrical features and spray behavior was proposed. Micronsized aluminum powders and compressed air as carrier gas were used in this experimentation, numerical simulations are performed to predict the gas flow regime. It has been found that the deposition efficiency tends to decrease due to the critical phenomena occur into the spray nozzle during long time depositions. The sprayed particles tend to stick to the walls of the nozzle and, moreover, shock waves occur inside the nozzle further promoting the particles stick phenomena, making the system inefficient

Biomarkers of aging in frailty and age-associated disorders: state of the art and future perspective

: According to the Geroscience concept that organismal aging and age-associated diseases share the same basic molecular mechanisms, the identification of biomarkers of age that can efficiently classify people as biologically older (or younger) than their chronological (i.e. calendar) age is becoming of paramount importance. These people will be in fact at higher (or lower) risk for many different age-associated diseases, including cardiovascular diseases, neurodegeneration, cancer, etc. In turn, patients suffering from these diseases are biologically older than healthy age-matched individuals. Many biomarkers that correlate with age have been described so far. The aim of the present review is to discuss the usefulness of some of these biomarkers (especially soluble, circulating ones) in order to identify frail patients, possibly before the appearance of clinical symptoms, as well as patients at risk for age-associated diseases. An overview of selected biomarkers will be discussed in this regard, in particular we will focus on biomarkers related to metabolic stress response, inflammation, and cell death (in particular in neurodegeneration), all phenomena connected to inflammaging (chronic, low-grade, age-associated inflammation). In the second part of the review, next-generation markers such as extracellular vesicles and their cargos, epigenetic markers and gut microbiota composition, will be discussed. Since recent progresses in omics techniques have allowed an exponential increase in the production of laboratory data also in the field of biomarkers of age, making it difficult to extract biological meaning from the huge mass of available data, Artificial Intelligence (AI) approaches will be discussed as an increasingly important strategy for extracting knowledge from raw data and providing practitioners with actionable information to treat patients

QUALITY OF LIFE AFTER PENILE PROSTHESIS IMPLANTATION \u2013 1 YEAR FOLLOW-UP DATA OF THE ITALIAN PROSPECTIVE REGISTRY INSIST-ED

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Surgeons’ practice and preferences for the anal fissure treatment: results from an international survey

The best nonoperative or operative anal fissure (AF) treatment is not yet established, and several options have been proposed. Aim is to report the surgeons' practice for the AF treatment. Thirty-four multiple-choice questions were developed. Seven questions were about to participants' demographics and, 27 questions about their clinical practice. Based on the specialty (general surgeon and colorectal surgeon), obtained data were divided and compared between two groups. Five-hundred surgeons were included (321 general and 179 colorectal surgeons). For both groups, duration of symptoms for at least 6 weeks is the most important factor for AF diagnosis (30.6%). Type of AF (acute vs chronic) is the most important factor which guide the therapeutic plan (44.4%). The first treatment of choice for acute AF is ointment application for both groups (59.6%). For the treatment of chronic AF, this data is confirmed by colorectal surgeons (57%), but not by the general surgeons who prefer the lateral internal sphincterotomy (LIS) (31.8%) (p = 0.0001). Botulin toxin injection is most performed by colorectal surgeons (58.7%) in comparison to general surgeons (20.9%) (p = 0.0001). Anal flap is mostly performed by colorectal surgeons (37.4%) in comparison to general surgeons (28.3%) (p = 0.0001). Fissurectomy alone is statistically significantly most performed by general surgeons in comparison to colorectal surgeons (57.9% and 43.6%, respectively) (p = 0.0020). This analysis provides useful information about the clinical practice for the management of a debated topic such as AF treatment. Shared guidelines and consensus especially focused on operative management are required to standardize the treatment and to improve postoperative results