Handbook for Implementing a Comprehensive Work-Based Learning Program According to the Fair Labor Standards Act

This Handbook for Implementing a Comprehensive Work-Based Learning Program According to the Fair Labor Standards Act provides guidance to schools operating WBL programs and encourages the adoption of WBL programs by schools not presently using this approach. By following the information and examples in this handbook, schools can proceed with confidence to operate effective WBL programs consistent with the FLSA

Carrie Johnson Scrapbook Pages

Loose scrapbook pages that no longer remain in their original book of Carrie Johnson (attended 1913-1914). Considering her short time at Hollins College, it is likely this scrapbook is from her freshman year in 1913-1914. However, there are no definitive dates for this scrapbook. Photos include Hollins College buildings and scenery as well as photos of students.https://digitalcommons.hollins.edu/scrapbooks/1031/thumbnail.jp

Endocrine and reproductive responses to implants of deslorein acetate in horses

Four experiments were performed to study the effects of the gonadotropin releasing hormone (GnRH) analog, deslorelin acetate (Ovuplant™), on endocrine and reproductive characteristics in mares. The first experiment tested whether anecdotal field reports of Ovuplant causing extended interovulatory intervals would be detectable under controlled, experimental conditions. The use of Ovuplant to hasten ovulation in 13 mares, compared to 12 controls, increased (P \u3c 0.05) the interovulatory interval by 6.2 d and suppressed (P \u3c 0.05) plasma concentrations of both luteinizing hormone (LH) and follicle stimulating hormone (FSH) for approximately 11 d. Two mares receiving Ovuplant did not return to estrus within 30 d. In the second experiment, 10 control mares and 10 mares induced to ovulate with Ovuplant were administered GnRH (50 μg) on d 1, 4, 7, and 10 after ovulation. Again, treated mares had a longer (4.4 d, P \u3c 0.05) interovulatory interval and suppressed LH and FSH concentrations in daily plasma samples. The gonadotropin response to GnRH was lower (P \u3c 0.05) in the deslorelin mares on d 1, 4, and 7, indicating a lack of pituitary responsiveness. In the third experiment, 9 stallions and 12 steroid-treated geldings were used to determine if males were potential models for studying the deslorelin-induced gonadotropin suppression. In both cases, treatment with Ovuplant caused an initial rise in both gonadotropins followed by suppression for about 14 d. In the last experiment, 21 mares were used to determine if multiple doses of deslorelin would cause complete ovarian shutdown. Mares received either sham injections, three Ovuplant implants on the first day, or one implant per day for 3 d (n = 7 per group). Treatment with multiple deslorelin implants increased (P \u3c 0.05) the interovulatory interval by 14.8 d and suppressed LH and FSH concentrations for approximately 25 d, however no mares exhibited complete ovarian shutdown. In conclusion, deslorelin acetate implants in horses in the form of Ovuplant induce short-term increases in LH and FSH secretion followed by long-term suppression of these concentrations and an insensitivity of the pituitary to GnRH. In a small percentage of mares, long-term ovarian shutdown is a possibility

The Coordination Status of the Children\u27s Mental Health Services in Minnesota

The purpose of the present study is to describe what services children with severe emotional disturbance (SED) have received before acute care hospitalization. According to the Minnesota children\u27s Mental Health Act of 1989, children should be receiving a comprehensive set of services. This means that the children\u27s mental health system is to be integrated and coordinated with all child-serving systems at the state, local and individual levels . This study examines the following three research questions: a) Is coordination of services being provided across disciplines?, b) Are children receiving case-management services?, and c) Are children receiving services in the least restrictive setting first before moving to more restrictive environments?. Twenty (20) adolescents were interviewed on a psychiatric unit of an acute care hospital. The findings indicate that all services are being provided as described in the research questions and are in accordance with the 1989 Children\u27s Mental Health Act

Discovery and Development of Small Molecule Probes for the SUMO protease SENP1, a Novel Target for Advanced Prostate Cancer Therapy

Androgen signaling through the androgen receptor (AR) is essential for normal growth and function of the prostate gland. In prostate cancer (PC), androgens provide the main proliferative drive for the disease, making androgen-deprivation one of the primary therapeutic strategies. Although initially effective, such treatments select for tumor cells that are able to sustain proliferation in a reduced androgen environment.  This allows for the emergence of castration resistant PC, an incurable disease where both the AR transcriptional program is subverted and cellular senescence is evaded. SUMOylation is a post-translational modification that regulates both of these processes. SUMOylation of AR inhibits both basal and androgen-stimulated transcription in a promoter context manner and enhanced global SUMO modification induces prostate cell senescence. Advanced PC cells evade these mechanisms at least in part through the upregulation of SENP1, a SUMO-specific cysteine protease that reverses SUMOylation. In addition, AR is a direct activator of the SENP1 gene, creating a self-reinforcing loop that promotes and sustains its own activity and PC progression. This dissertation is aimed at the discovery and development of small molecule inhibitors of SENP1 as the basis for novel prostate cancer therapeutics. Using a robust FRET-based assay, we defined the kinetic properties of SENP1 and its closest paralog SENP2. This analysis revealed significant product inhibition and a differential sensitivity to ionic strength. Using this assay, an extensive high-throughput screening campaign led to the identification of two structurally distinct inhibitor classes. Characterization of these compounds indicates that they display significant selectivity towards SENP1 relative to SENP2 and that they act in both a reversible and competitive manner. Furthermore, these compounds inhibit native full-length SENP1 acting on endogenous SUMOylated substrates. Notably, both groups of compounds are known to display activity as purinergic receptor antagonists. The remarkable parallel pharmacology to P2X1 receptors led to our discovery that ATP, the endogenous P2X ligand, is a SENP1 selective inhibitor. We have thus revealed a novel nucleotide mediated regulation of SENP1. Using a combination of mutagenesis, biochemical assays, and fluorescence and NMR spectroscopy, we have characterized the binding of inhibitors and identified key enzyme residues involved in the interactions as well as residues responsible for SENP isoform selectivity. These findings reveal that SENP1 harbors a unique binding site for nucleotides that can be targeted by small molecules. This knowledge can guide novel strategies for further inhibitor development for evaluation of the therapeutic efficacy of SENP1 inhibitors in advanced prostate cancer models.PHDChemical BiologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/140973/1/carriemn_1.pd

Right to leisure through play for refugee children in Egypt

Physical health programs specifically programmed for emotional rehabilitation are an important factor in post-trauma adjustment for refugee children in Egypt. This thesis explores definitions of the Right to Leisure, which can serve as a catalyst for such post-trauma rehabilitation for refugee children. Adequate access to the right to leisure is obstructed, however due to State-wide economic weaknesses, the failed implementation and reservations to various international treaties, xenophobia and discrimination, and the vast privatization of recreation spaces. Nonetheless, Egypt has consented to sharing international responsibility to safeguard the right to leisure for refugee children per several international treaties: the Convention on the Rights of the Child and the Refugee Convention. Egypt has also consented to similar rights expressed in the International Covenant of Economic and Social Rights and the African Charter. Considering Egypt’s economic incapacity, the State should act in good faith by vowing to not interfere with entities working to realize the right to leisure within the country. In fact, the Egyptian State must coordinate efforts with international organizations, universities and civil society to create access to the right to leisure within the country

Do new student loan borrowers know what they are signing? A phenomenological study of the financial aid experiences of high school seniors and college freshmen.

The purpose of this study is to investigate the overall financial aid process from the perspective of first-time students and their parents. It seeks to determine their understanding of the entire financial aid process from completing the Free Application for Federal Student Aid (FAFSA) to when the students receive their first disbursement of funds. This qualitative study of eight individuals who completed the process focuses on how well students and their families understand the terms and conditions of repayment of student loans. Both parents and students were interviewed for the purpose of this study to determine if students or their parents are the ones who complete the process. This study also seeks to determine if less technology or conducting face-to-face loan counseling would help participants understand the terms of loans and repayment options better

Literature-based language arts extended to mathematics

A literature-based language arts program provides opportunities for children to create meaning through quality literature experiences. Children\u27s learning is integrated, and connections are made across the curriculum. The mathematics and language process are related and can be integrated into units of study through the genres of literature. A unit of study on circles provided kindergarten children with quality literature and related expressive activities that facilitated the understanding of the concept of circle. As a result of this literature-based language arts program extended to mathematics, children\u27s knowledge was integrated, peer interaction increased, and the reading-writing processes were connected. Children\u27s enthusiasm for quality literature, and expressive activities through participation at centers, increased as the unit of study progressed

Tensions Between Catholic Identity and Academic Achievement at an Urban Catholic High School

Through a secondary analysis of a case study on successful school leadership, this study inquired into the lived experiences and understandings of Catholic identity from the perspectives of administrators, faculty, staff, and students at one urban Catholic school in the northeastern United States. Participants generally spoke about Catholic identity in terms of its explicit or implicit nature. Specifically, explicit Catholic identity relating to campus ministry, faith formation of students, and community service were noted to be areas for improvement. The analysis showed that tensions concerning the school’s Catholic identity were sidelined in the pursuit of academic excellence as measured by standardized tests, benchmarks, and college acceptance rates. We argue that embracing and taking seriously, rather than avoiding, the tensions concerning Catholic identity in a Catholic school might contribute to vital community dialogue, invigorating learning, and consequent spiritual and academic growth

Alternative Service Delivery Models for Students with Learning Disabilities

More than 40 years of intervention research describes effective interventions for increasing the academic performance of students with learning disabilities. However, the performance and outcomes for students with learning disabilities remain discouraging, especially in light of the increasing cost to provide special education services. Between 60 – 70 percent of students with learning disabilities are unable to meet grade level performance standards in the basic academic areas of reading, writing and mathematics. The disconnect between research and practice suggests a need for rethinking special education service delivery. This paper reports the results of a program evaluation of a not-for-profit center specializing in working with students with learning disabilities, comparing the pre to post test gains and program costs to those typically seen in public education special education systems. A paired samples t-test examined pre to post test differences in reading, math and writing performance for a total of 104 students with learning disabilities between the ages of 6–17. Results were statistically and practically significant across all areas, and these results were obtained at costs much lower than those incurred under the current public education model. Implications for future research are discussed