Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions

Semianalytical method for contact mechanic among shaft and bearing of a submarine vehicle

En el presente trabajo, se estudia y analiza el mejor ajuste del eje del propulsor de un vehículo sumergible a su chumacera, mediante el estudio de la geometría de contacto entre dichos elementos. Para realizar este estudio, se ha aplicado un método semianalítico, basado en las normas de la cuadratura de los principales valores de Cauchy, el método de la secante, y un método numérico para la determinación del mapa tensional de las superficies en contacto entre el eje y la chumacera. Asumiendo que existen imperfecciones de micras en el mecanizado de las superficies en contacto, estas son una causa posible de daños subsuperficiales que favorecen fallos por picaduras (pitting ) o la formación y el crecimiento de las grietas por fatiga. Estos fallos afectan no solo el buen rendimiento propulsivo, sino también las condiciones de estanqueidad, con los consiguientes riesgos que ello supone para la integridad del buque. Los resultados permiten establecer los criterios de diseño en función de los módulos de Young, así como un mecanizado correcto y el ajuste de holguras posterior del sistema eje-chumacera, con lo cual se mejorala fiabilidad de dichos elementos.The present study analyzes the best attachment of the propeller shaft of a submersible to his bearing, studying geometry of contact between those elements. A semi-analytical method based on the rules of the quadrature of the main values of Cauchy, the secant method and a numerical method for determining a tension map have been applied to the study of the contact surfaces between shaft and bearing. It is assumed that there are imperfections in the order of microns when machining the contact surfaces, which can produce subsurface damage that is possible, linked to pitting and the growth of fatigue cracks. Such failures not only will influence on the proper propulsive performance, but also on the watertightness conditions, which is related to the risk of ship integrity loss. The results let us to set design criteria, which account for the Youngs module and the importance of an adequate machining and further adjustment of clearances on the shaft-bearing system, thus improving the reliability of such elements.Peer Reviewe

Nanocrystals of Ni doped ZnO semiconductor by Sol-Gel combustion method

Nanoparticles of the system Zn0.95Ni0.05O were prepared by sol gel self- combustion method and a study of their structural, optical andmagnetic properties were conducted. X-ray diffraction study shows a hexagonal wurtzite structure for the nanocompound. The formation ofthe wurtzite structure in Ni doped ZnO was further confirmed by Fourier transform infra-red spectrometry. Transmission electron microscopyrevealed an average size of 31 nm for the particles. Optical absorption spectra shows that the band energy of Zn0.95Ni0.05O powders is about2.54 eV at room temperature. A study of the magnetic properties of the nanopowders of ZnO: Ni, reveals paramagnetic behavior, withinteraction ferromagnetic between particles.Fil: Carrero Lobo, Aneely Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Los Andes; VenezuelaFil: Sagredo, V.. Universidad de Los Andes; VenezuelaFil: Larionova, J.. Université Montpellier II; Franci

Clinical study of cervicogenic headache

The cervicogenic headache was studied to get a deeper insight into the pathogenetic mechanisms, and clinical presentation forms. Material and Methods. Eleven female patients, ranging from 34 to 81 years-old, with cervicogenic headaches, were studied and correlated with NMR images of the cervical spine. Results. Intense neck pain irradiated to parietal, occipital, temporal regions, and shoulders were correlated with NMR images of the degenerated cervical spine. Also, lumbar spine pathology, osteoporosis, gallstones, and cholecystitis were found. The following associated neurological, neurobehavioral, and metabolic diseases comorbidities were observed, such as blood hypertension, diabetes, obesity, hypothyroidism, partial epilepsy, tremor, familial stress, memory, sleep disorders, and dizziness. Also, we found mixed cervicogenic headaches and migraines in 50% of cases studied. Conclusion. The headache and the associated images of cervical pathology have been clinically interpreted as cardinal signs of cervicogenic headache. A mixed cervicogenic mixed type was observed

Intelligent copolymers based on poly (N-isopropylacrylamide) PNIPAm with potential use in biomedical applications. Part i: PNIPAm functionalization with 3-butenoic acid and piperazine

The synthesis and characterization of the thermosensitive copolymers based on Poly (N-Isopropylacrylamide) (PNIPAm) and 3-butenoic acid and functionalized with piperazine was carried out. The free radical polymerization of the PNIPA copolymer with 3-butenoic acid was performed under microwave radiation. After obtaining this copolymer, the carboxyl groups present in the copolymer chain were activated with 1-ethyl- (3-3-dimethylaminopropyl) carbodiimide in the presence of N-hydroxysuccinimide, improving its reactivity to incorporate the piperazine through its amino group. The characterization consisted: differential scanning calorimetric and ultraviolet-visible spectrophotometry to determine the LCST phase transition temperature, ranging from (30-35)°C. Structurally it was analyzed by infrared spectroscopy. A morphological analysis was performed using scanning electron microscopy, after simulating an injectable process, with the objective to observe internally the porosity and interconnectivity. The biocompatibility was evaluated through hemocompatibility tests and it was observed that the copolymers obtained were not cytotoxic. In base of the results, the chemical structure of these new copolymers confers a functionality that allows them to serve as nuclei to graft other molecules, such as polysaccharides. Then, the results obtained on the LCST temperature, porosity, interconnected pore network morphology, the ability to be injectable and the biocompatible nature of these copolymers are indicative that these new synthetic biomaterials have the potential to be used in biomedical, pharmacological and for tissue engineering. Also, once their biocompatibility was demonstrate, they may serve to generate interesting compounds having chemical anchor points for the possible addition of polysaccharides using insertion reactions, thereby generating graft copolymers with potential use in biomedical applications

Herida antebraquial infectada por Aeromonas hydrophila

Se presenta un caso de celulitis por Aeromonas hydrophila, en un paciente de 23 años, tras una herida antebraquial producida en el medio acuático. La celulitis se resolvió mediante desbridamiento agresivo y quimioterapia. En los controles posteriores no se han apreciado déficits funcionales tras la infección.A case of Aeromonas hidrophila cellulitis developped in a 23-year-old patient, after aquatic environment forearm wound is presented. His cellulitis was effectively resolved with aggressive debridement and chemotherapy. Follow-up examinations have shown no residual functional deficits from the infection

Integrated Planning of Industrial Gas Supply Chains

In this work, we propose a Mixed Integer Linear Programming (MILP) model for optimal planning of industrial gas supply chain, which integrates supply contracts, production scheduling, truck and rail-car scheduling, as well as inventory management under the Vendor Managed Inventory (VMI) paradigm. The objective used here is minimisation of the total operating cost consisting of purchasing of raw material, production, and transportation costs by trucks/rail-cars so as to satisfy customer demands over a given time horizon. The key decisions for production sites include production schedule and purchase schedule of raw material, while the distribution decisions involve customer to plant/depot allocation, quantity transported through rail network, truck delivery amounts, and times. In addition, a relaxation approach is proposed to solve the problem efficiently. An industrial case study is evaluated to illustrate the applicability of the integrated optimisation framework