Vitamin C in Health and Disease

Vitamin C is a pivotal water soluble electron donor in nature and an essential nutrient in man. Despite its many years as a research focus, new and increasingly regulatory functions of vitamin C in human health are continually being unravelled. This improved mechanistic insight is starting to provide rationales explaining the extensive epidemiological literature that, for decades, has consistently shown strong associations between poor vitamin C status and increased morbidity and mortality. In this Special Issue, we include original research and literature reviews by experts in the field outlining the roles of vitamin C in early, daily and late life, as well as the roles of deficiency in cardiovascular disease, inflammation and cancer

Vitamin C: Current Concepts in Human Physiology

ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [Vitamin C is synthesized by almost all animals. However, for humans, it is a vitamin that needs constant replenishment in the diet. While its role as an anti-oxidant and for preventing scurvy have been known for a long time, novel functions and unrecognized associations continue to be identified for this enigmatic molecule. In the past decade, new details have emerged regarding differences in its uptake by oral and intravenous modes. While vitamin C deficiency remains largely unknown and poorly addressed in many segments of the population, novel pharmacological roles for high-dose, intravenous vitamin C in many disease states have now been postulated and investigated. This has shifted its role in health and disease from the long-perceived notion as merely a vitamin and an anti-oxidant to a pleiotropic molecule with a broad anti-inflammatory, epigenetic, and anti-cancer profile. This Special Issue comprises original research papers and reviews on vitamin C metabolism and function that relate to the following topics: understanding its role in the modulation of inflammation and immunity, therapeutic applications and safety of pharmacological ascorbate in disease, and the emerging role of vitamin C as a pleiotropic modulator of critical care illness and cancer.

Survey of existing fingerprint countermeasures

A number of fingerprint countermeasures have claimed that their countermeasures can prevent the user away from fingerprint tracking. The research attempts to prove their claims and requires to study the effectiveness of their fingerprint prevention and observe the results of side effects after defence in order to assist the attentive user to know the limitation of current approaches. Under investigation, all countermeasures will be installed on the web browser and visit the developed hybrid fingerprint website in order to know the efficiency of the fingerprint resistance of all types. The research shows that all fingerprint countermeasures nowadays are unable to obstruct all kinds of the fingerprint tracking and countermeasures that use the blocking technique appear more side effects to the web browser than other techniques. Also, the increasing number of fingerprint attributes are increasing cause of unusual combination inside the Internet browser

Energy and technology review

Brief discussions are given on research work at the National CTR Computer Center at Livermore, high-field superconducting magnets for fusion reactors, and digital image processing for plasma diagnostics. Some developmental work on multifilamentary superconductors of Nb--Ti and Nb--Sn is described. Some complex mathematical techniques for enhancing and restoring digital images for plasma diagnostics are discussed. (MOW

On the Efficient Calculation of a Linear Combination of Chi-Square Random Variables with an Application in Counting String Vacua

Linear combinations of chi square random variables occur in a wide range of fields. Unfortunately, a closed, analytic expression for the pdf is not yet known. As a first result of this work, an explicit analytic expression for the density of the sum of two gamma random variables is derived. Then a computationally efficient algorithm to numerically calculate the linear combination of chi square random variables is developed. An explicit expression for the error bound is obtained. The proposed technique is shown to be computationally efficient, i.e. only polynomial in growth in the number of terms compared to the exponential growth of most other methods. It provides a vast improvement in accuracy and shows only logarithmic growth in the required precision. In addition, it is applicable to a much greater number of terms and currently the only way of computing the distribution for hundreds of terms. As an application, the exponential dependence of the eigenvalue fluctuation probability of a random matrix model for 4d supergravity with N scalar fields is found to be of the asymptotic form exp(-0.35N).Comment: 21 pages, 19 figures. 3rd versio

Primordial Black Holes: sirens of the early Universe

Primordial Black Holes (PBHs) are, typically light, black holes which can form in the early Universe. There are a number of formation mechanisms, including the collapse of large density perturbations, cosmic string loops and bubble collisions. The number of PBHs formed is tightly constrained by the consequences of their evaporation and their lensing and dynamical effects. Therefore PBHs are a powerful probe of the physics of the early Universe, in particular models of inflation. They are also a potential cold dark matter candidate.Comment: 21 pages. To be published in "Quantum Aspects of Black Holes", ed. X. Calmet (Springer, 2014

Migrants as sustainability actors:Contrasting nation, city and migrant discourses and actions

Although it is widely recognized that migration is socially transformative, the potential contributions of migrants to transformations towards sustainability in their destination areas are often overlooked in mainstream discourse on environmentalism and sustainability. Here we seek to identify current narratives of migrants and sustainability across individual, urban, and national scales. Migrants are commonly framed in public policy as having no or even negative impacts on sustainability. The study hypotheses that the lived experience of sustainability by migrants within urban destinations differ from dominant discourses and perceptions of migrant populations within societies. We test and document such divergence using data from 21 interviews with key stakeholders from the city and Swedish national level, an attitudinal survey of 895 migrants and non-migrants in Malmö, Sweden; and a media analysis of local and national Swedish newspapers. Survey results show that migrants engage more extensively with a number of sustainability actions compared to non-migrants culminating in new insights on ‘migrants as sustainability actors’. By contrasting individual scale practices against urban to national sustainability narratives, the study illuminates current barriers to and the potential of migrants to play a transformative role in progress towards sustainability that is unrecognized in dominant policy discourses. To tap into this potential, the study emphasizes that sustainability policy across scales should embrace plurality and migration as fundamental parts of progress towards sustainability.</p

Migrants as sustainability actors:Contrasting nation, city and migrant discourses and actions

Although it is widely recognized that migration is socially transformative, the potential contributions of migrants to transformations towards sustainability in their destination areas are often overlooked in mainstream discourse on environmentalism and sustainability. Here we seek to identify current narratives of migrants and sustainability across individual, urban, and national scales. Migrants are commonly framed in public policy as having no or even negative impacts on sustainability. The study hypotheses that the lived experience of sustainability by migrants within urban destinations differ from dominant discourses and perceptions of migrant populations within societies. We test and document such divergence using data from 21 interviews with key stakeholders from the city and Swedish national level, an attitudinal survey of 895 migrants and non-migrants in Malmö, Sweden; and a media analysis of local and national Swedish newspapers. Survey results show that migrants engage more extensively with a number of sustainability actions compared to non-migrants culminating in new insights on ‘migrants as sustainability actors’. By contrasting individual scale practices against urban to national sustainability narratives, the study illuminates current barriers to and the potential of migrants to play a transformative role in progress towards sustainability that is unrecognized in dominant policy discourses. To tap into this potential, the study emphasizes that sustainability policy across scales should embrace plurality and migration as fundamental parts of progress towards sustainability.</p

Making Climate Services Work for Africa's Farmers at Scale

The substantial body of knowledge about good practice in climate services suggests that making climate services work for farmers at a national scale requires managing tradeoffs between meeting farmers’ context-specific needs and providing cost-effective services at scale

Advancing Impact Evaluations of Agricultural Climate Services in Africa

The design and implementation of effective climate information services (CIS) requires understanding the extent to which they impact the decisions and lives of those who use them