Review: emerging concepts in the pathogenesis of tendinopathy

Tendinopathy is a common clinical problem and has a significant disease burden attached, not only in terms of health care costs, but also for patients directly in terms of time off work and impact upon quality of life. Controversy surrounds the pathogenesis of tendinopathy, however the recent systematic analysis of the evidence has demonstrated that many of the claims of an absence of inflammation in tendinopathy were more based around belief than robust scientific data. This review is a summary of the emerging research in this topical area, with a particular focus on the role of neuronal regulation and inflammation in tendinopathy

Stringy Effects During Inflation and Reheating

We consider inflationary cosmology in the context of string compactifications with multiple throats. In scenarios where the warping differs significantly between throats, string and Kaluza-Klein physics can generate potentially observable corrections to the cosmology of inflation and reheating. First we demonstrate that a very low string scale in the ground state compactification is incompatible with a high Hubble scale during inflation, and we propose that the compactification geometry is altered during inflation. In this configuration, the lowest scale is just above the Hubble scale, which is compatible with effective field theory but still leads to potentially observable CMB corrections. Also in the appropriate region of parameter space, we find that reheating leads to a phase of long open strings in the Standard Model sector (before the usual radiation-dominated phase). We sketch the cosmology of the long string phase and we discuss possible observational consequences.Comment: 33pp, RevTeX4, v2. minor changes, added ref

Analysis of Carbon across the Cenomanian-Turonian Boundary

Following the work of Wolbach et al., who studied reduced carbon across the 65 Ma-old Cretaceous-Tertiary extinction boundary, a study was conducted to analyze reduced carbon across the 92 Ma-old Cenomanian-Turonian (C-T) extinction horizon, in the hope that evidence could be gathered which might support a particular mechanism for these extinction events. Currently two sample sites are being analyzed for reduced carbon content at the C-T boundary: Red Wash, New Mexico and Chispa Summit, Texas. Both sample sites are from the Western Interior Basin of North America. During the time of the extinctions 92 million years ago, the basin was an inland sea. Preliminary data suggest a decrease in the amount of carbonaceous residue found at the boundary at both sample sites. This would indicate that the extinction event was not rapid, as lower amounts of reduced carbon are generally more characteristic of extinctions caused by slow changes in climate vs sudden changes caused by catastrophic events. Slow climate changes would allow microorganisms time to digest (oxidize) the carbon in dead plankton before sedimentation, thus decreasing the amount of reduced carbon preserved in the rock. A mechanism for the C-T extinctions consistent with previous data as well as preliminary results obtained in this study is the opening of deep sea fissures at the ocean floor, increasing certain metal concentrations in seawater, and, more importantly, increasing water temperatures. Plankton unable to adapt to these new conditions would become extinct

Prevalence of rotator cuff tendon tears and symptoms in a Chingford general population cohort, and the resultant impact on UK health services: a cross-sectional observational study

Objectives To define the population prevalence of rotator cuff tears and test their association with pain and function loss; determine if severity symptom correlates with tear stage severity, and quantify the impact of symptomatic rotator cuff tears on primary healthcare services in a general population cohort of women. Design Cross-sectional observational study. Participants Individuals were part of the Chingford 1000 Women cohort, a 20-year-old longitudinal population study comprising 1003 women aged between 64 and 87, and representative of the population of the UK. Main outcome measures Rotator cuff pathology prevalence on ultrasound, shoulder symptoms using the Oxford Shoulder Score and resultant number of general practitioner (GP) consultations. Results The population prevalence of full-thickness tears was 22.2%, which increased with age (p=0.004) and whether it was the dominant arm (Relative Risk 1.64, OR 1.58, 95% CI 1.07 to 2.33, p=0.021). Although 48.4% of full-thickness tears were asymptomatic, there was an association between rotator cuff tears and patient-reported symptoms. Individuals with at least one full-thickness tear were 1.97 times more likely than those with bilateral normal tendons (OR 3.53, 95% CI 2.00 to 5.61, p2.5 cm (p=0.009). In the cohort, 8.9% had seen their GP with shoulder pain and a full-thickness rotator cuff tear, 18.8% with shoulder pain and an abnormality and 29.3% with shoulder pain. Conclusion Rotator cuff tears are common, and primary care services are heavily impacted. As 50% of tears remain asymptomatic, future research may investigate the cause of pain and whether different treatment modalities, aside from addressing the pathology, need further investigation

Seasonal Climatology of Hydrographic Conditions in the Upwelling Region Off Northern Chile

Over 30 years of hydrographic data from the northern Chile (18 degreesS-24 degreesS) upwelling region are used to calculate the surface and subsurface seasonal climatology extending 400 km offshore. The data are interpolated to a grid with sufficient spatial resolution to preserve cross-shelf gradients and then presented as means within four seasons: austral winter (July-September), spring (October-December), summer (January-March), and fall (April-June). Climatological monthly wind forcing, surface temperature, and sea level from three coastal stations indicate equatorward (upwelling favorable) winds throughout the year, weakest in the north. Seasonal maximum alongshore wind stress is in late spring and summer (December-March). Major water masses of the region are identified in climatological T-S plots and their sources and implied circulation discussed. Surface fields and vertical transects of temperature and salinity confirm that upwelling occurs year-round, strongest in summer and weakest in winter, bringing relatively fresh water to the surface nearshore. Surface geostrophic flow nearshore is equatorward throughout the year. During summer, an anticyclonic circulation feature in the north which extends to at least 200 m depth is evident in geopotential anomaly and in both temperature and geopotential variance fields. Subsurface fields indicate generally poleward flow throughout the year, strongest in an undercurrent near the coast. This undercurrent is strongest in summer and most persistent and organized in the south (south of 21 degreesS), A subsurface oxygen minimum, centered at similar to 250 m, is strongest at lower latitudes. Low-salinity subsurface water intrudes into the study area near 100 m, predominantly in offshore regions, strongest during summer and fall and in the southernmost portion of the region. The climatological fields are compared to features off Baja within the somewhat analogous California Current and to measurements from higher latitudes within the Chile-Peru Current system

Satellite-Measured Chlorophyll and Temperature Variability Off Northern Chile During the 1996-1998 La Niña and El Niño

Time series of satellite measurements are used to describe patterns of surface temperature and chlorophyll associated with the 1996 cold La Nina phase and the 1997-1998 warm El Nino phase of the El Nino - Southern Oscillation cycle in the upwelling region off northern Chile. Surface temperature data are available through the entire study period. Sea-viewing Wide Field-of-view Sensor (SeaWiFS) data first became available in September 1997 during a relaxation in El Nino conditions identified by in situ hydrographic data. Over the time period of coincident satellite data, chlorophyll patterns closely track surface temperature patterns. Increases both in nearshore chlorophyll concentration and in cross-shelf extension of elevated concentrations are associated with decreased coastal temperatures during both the relaxation in El Nino conditions in September-November 1997 and the recovery from EI Nino conditions after March 1998. Between these two periods during austral summer (December 1997 to March 1998) and maximum El Nino temperature anomalies, temperature patterns normally associated with upwelling were absent and chlorophyll concentrations were minimal. Cross-shelf chlorophyll distributions appear to be modulated by surface temperature frontal zones and are positively correlated with a satellite-derived upwelling index. Frontal zone patterns and the upwelling index in 1996 imply an austral summer nearshore chlorophyll maximum, consistent with SeaWiFS data from I 1998-1999, after the El Nino. SeaWiFS retrievals in the data set used here are higher than in situ measurements by a factor of 2-4; however, consistency in the offset suggests relative patterns are valid