13,121 research outputs found

    Patient's breath controls comfort devices

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    Patient assist system for totally disabled persons was developed which permits a person, so paralyzed as to be unable to move, to activate by breathing, a call system to summon assistance, turn the page of a book, ajust his bed, or do any one of a number of other things. System consists of patient assist control and breath actuated switch

    The influence of normal stress and sliding velocity on the frictional behaviour of calcite at room temperature. Insights from laboratory experiments and microstructural observations

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    The presence of calcite in and near faults, as the dominant material, cement, or vein fill, indicates that the mechanical behaviour of carbonate-dominated material likely plays an important role in shallow- and mid-crustal faulting. To better understand the behaviour of calcite, under loading conditions relevant to earthquake nucleation, we sheared powdered gouge of Carrara Marble, >98 per cent CaCO3, at constant normal stresses between 1 and 100 MPa under water-saturated conditions at room temperature. We performed slide-hold-slide tests, 1–3000 s, to measure the amount of static frictional strengthening and creep relaxation, and velocity-stepping tests, 0.1–1000 µm s–1, to evaluate frictional stability. We observe that the rates of frictional strengthening and creep relaxation decrease with increasing normal stress and diverge as shear velocity is increased from 1 to 3000 µm s–1 during slide-hold-slide experiments. We also observe complex frictional stability behaviour that depends on both normal stress and shearing velocity. At normal stresses less than 20 MPa, we observe predominantly velocity-neutral friction behaviour. Above 20 MPa, we observe strong velocity-strengthening frictional behaviour at low velocities, which then evolves towards velocity-weakening friction behaviour at high velocities. Microstructural analyses of recovered samples highlight a variety of deformation mechanisms including grain size reduction and localization, folding of calcite grains and fluid-assisted diffusion mass transfer processes promoting the development of calcite nanograins in the highly deformed portions of the experimental fault. Our combined analyses indicate that calcite fault gouge transitions from brittle to semi-brittle behaviour at high normal stress and slow sliding velocities. This transition has important implications for earthquake nucleation and propagation on faults in carbonate-dominated lithologies

    NICMOS2 hubble space telescope observations of the embedded cluster associated with Mon R2: Constraining the substellar initial mass function

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    We have analyzed Hubble Space Telescope NICMOS2 F110W-, F160W-, F165M-, and F207M-band images covering the central 1' × 1' region of the cluster associated with Mon R2 in order to constrain the initial mass function (IMF) down to 20M_J. The flux ratio between the F165M and F160W bands was used to measure the strength of the water-band absorption feature and select a sample of 12 out of the total sample of 181 objects that have effective temperatures between 2700 and 3300 K. These objects are placed in the H-R diagram together with sources observed by Carpenter et al. to estimate an age of ~1 Myr for the low-mass cluster population. By constructing extinction-limited samples, we are able to constrain the IMF and the fraction of stars with a circumstellar disk in a sample that is 90% complete for both high- and low-mass objects. For stars with estimated masses between 0.1 and 1.0 M_☉ for a 1 Myr population with A_V ≤ 19 mag, we find that 27% ± 9% have a near-infrared excess indicative of a circumstellar disk. The derived fraction is similar to or slightly lower than the fraction found in other star-forming regions of comparable age. We constrain the number of stars in the mass interval 0.08-1.0 M_☉ to the number of objects in the mass interval 0.02-0.08 M_☉ by forming the ratio R^(**) = N(0.08-1 M_☉)/N(0.02-0.08 M_☉) for objects in an extinction-limited sample complete for A_V ≤ 7 mag. The ratio is found to be R^(**) = 2.2 ± 1.3, assuming an age of 1 Myr, consistent with the similar ratio predicted by the system IMF proposed by Chabrier. The ratio is similar to the ratios observed toward the Orion Nebula Cluster and IC 348, as well as the ratio derived in the 28 deg^2 survey of Taurus by Guieu et al

    Missing data in trial-based cost-effectiveness analysis: An incomplete journey

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    Cost-effectiveness analyses (CEA) conducted alongside randomised trials provide key evidence for informing healthcare decision making, but missing data pose substantive challenges. Recently, there have been a number of developments in methods and guidelines addressing missing data in trials. However, it is unclear whether these developments have permeated CEA practice. This paper critically reviews the extent of and methods used to address missing data in recently published trial-based CEA. Issues of the Health Technology Assessment journal from 2013 to 2015 were searched. Fifty-two eligible studies were identified. Missing data were very common; the median proportion of trial participants with complete cost-effectiveness data was 63% (interquartile range: 47%-81%). The most common approach for the primary analysis was to restrict analysis to those with complete data (43%), followed by multiple imputation (30%). Half of the studies conducted some sort of sensitivity analyses, but only 2 (4%) considered possible departures from the missing-at-random assumption. Further improvements are needed to address missing data in cost-effectiveness analyses conducted alongside randomised trials. These should focus on limiting the extent of missing data, choosing an appropriate method for the primary analysis that is valid under contextually plausible assumptions, and conducting sensitivity analyses to departures from the missing-at-random assumption

    Statistical Properties of Avalanches in Networks

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    We characterize the distributions of size and duration of avalanches propagating in complex networks. By an avalanche we mean the sequence of events initiated by the externally stimulated `excitation' of a network node, which may, with some probability, then stimulate subsequent firings of the nodes to which it is connected, resulting in a cascade of firings. This type of process is relevant to a wide variety of situations, including neuroscience, cascading failures on electrical power grids, and epidemology. We find that the statistics of avalanches can be characterized in terms of the largest eigenvalue and corresponding eigenvector of an appropriate adjacency matrix which encodes the structure of the network. By using mean-field analyses, previous studies of avalanches in networks have not considered the effect of network structure on the distribution of size and duration of avalanches. Our results apply to individual networks (rather than network ensembles) and provide expressions for the distributions of size and duration of avalanches starting at particular nodes in the network. These findings might find application in the analysis of branching processes in networks, such as cascading power grid failures and critical brain dynamics. In particular, our results show that some experimental signatures of critical brain dynamics (i.e., power-law distributions of size and duration of neuronal avalanches), are robust to complex underlying network topologies.Comment: 11 pages, 7 figure

    Brain neurons as quantum computers: {\it in vivo} support of background physics

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    The question: whether quantum coherent states can sustain decoherence, heating and dissipation over time scales comparable to the dynamical timescales of the brain neurons, is actively discussed in the last years. Positive answer on this question is crucial, in particular, for consideration of brain neurons as quantum computers. This discussion was mainly based on theoretical arguments. In present paper nonlinear statistical properties of the Ventral Tegmental Area (VTA) of genetically depressive limbic brain are studied {\it in vivo} on the Flinders Sensitive Line of rats (FSL). VTA plays a key role in generation of pleasure and in development of psychological drug addiction. We found that the FSL VTA (dopaminergic) neuron signals exhibit multifractal properties for interspike frequencies on the scales where healthy VTA dopaminergic neurons exhibit bursting activity. For high moments the observed multifractal (generalized dimensions) spectrum coincides with the generalized dimensions spectrum calculated for a spectral measure of a {\it quantum} system (so-called kicked Harper model, actively used as a model of quantum chaos). This observation can be considered as a first experimental ({\it in vivo}) indication in the favour of the quantum (at least partially) nature of the brain neurons activity
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