Wave Propagation in Relativistic Electron-Positron Plasmas

The study of wave propagation in a plasma provides an invaluable insight into the plasma's fundamental behaviour and structure. In this thesis we study wave propagation in relativistic electron-positron plasmas. The effects of the mass symmetry of the two species on the plasma system are investigated in a regime where the energy of the plasma particles is of the same order of magnitude as their rest energy

Born Again French : Explaining Inconsistency in Citizenship Declarations in French Longitudinal Data

Citizenship is a fundamental boundary in contemporary societies that entails rights, a sense of belonging, and social status. Drawing on longitudinal census data, this article tracks individual changes in self-reported citizenship over 30 years in France. Respondents choose one of three categories: “French by birth,” “became French,” or “foreigner.” The first category should be stable over the life course: one is born, but cannot become, “French by birth.” Yet, our findings indicate that about 19 percent of foreign-origin respondents in a given census switch to “French by birth” declarations at the next census, in a process we call reclassification. Immigrant assimilation variables, such as nativity and length of stay, and events such as intermarriage, naturalization, and residential mobility, trigger reclassification. Yet reclassification is also higher among individuals with lower socioeconomic status and respondents of African and Southeast Asian origin, as well as those with origins in former French colonies. These findings suggest reclassification is a byproduct of immigrant assimilation, which triggers feelings of national identity, as well as status upgrading, whereby disadvantaged and discriminated groups change their citizenship declaration to compensate for low social status. Empirically novel, reclassification offers original theoretical insights into the meanings of citizenship, civic stratification, and boundary-crossing

Teacher educators teaching and learning together: A collaborative self-study of support within an online literacy learning community

Abstract In this self-study, five university instructors who taught the same online literacy course during a summer session formed an online learning community. Through engaging in email exchanges, participating in online discussions, posting weekly teaching reflections, and visiting one another's online courses, they sought to answer the research question: How can an online literacy learning community support university instructors who teach various sections of a common online course? In answering the research question, the researchers identified the themes that were most prominent in their discussions and reflections, and also the themes that played minor roles in the forming of the literacy learning community

ENHANCING COMMUNITY RESILIENCE: A HOLISTIC APPROACH TO ADDRESSING SUBSTANCE ABUSE IN BURKE COUNTY

Substance abuse in Burke County, NC has been a significant concern with rising overdose death rates despite targeted efforts. The proposal addresses substance abuse in Burke County with an emphasis on social and peer support in fostering community resilience and positive health outcomes. Social networks will be leveraged to provide resilience, coping mechanisms, and access to treatment and prevention resources. An analysis of substance abuse trends, demographics, and current support services was completed leading to recommendations for enhanced social and peer support systems. The proposed initiative aims for equity, accessibility, and sustainability, while recognizing the challenges of substance abuse, geographics, and privacy concerns. Evidence-based strategies along with stakeholder collaboration aim to achieve the goal of reducing substance abuse rates and improving overall community well-being in Burke County.Master of Public Healt

ENHANCING COMMUNITY RESILIENCE: A HOLISTIC APPROACH TO ADDRESSING SUBSTANCE ABUSE IN BURKE COUNTY

Substance abuse in Burke County, NC has been a significant concern with rising overdose death rates despite targeted efforts. The proposal addresses substance abuse in Burke County with an emphasis on social and peer support in fostering community resilience and positive health outcomes. Social networks will be leveraged to provide resilience, coping mechanisms, and access to treatment and prevention resources. An analysis of substance abuse trends, demographics, and current support services was completed leading to recommendations for enhanced social and peer support systems. The proposed initiative aims for equity, accessibility, and sustainability, while recognizing the challenges of substance abuse, geographics, and privacy concerns. Evidence-based strategies along with stakeholder collaboration aim to achieve the goal of reducing substance abuse rates and improving overall community well-being in Burke County.Master of Public Healt

ENHANCING COMMUNITY RESILIENCE: A HOLISTIC APPROACH TO ADDRESSING SUBSTANCE ABUSE IN BURKE COUNTY

Substance abuse in Burke County, NC has been a significant concern with rising overdose death rates despite targeted efforts. The proposal addresses substance abuse in Burke County with an emphasis on social and peer support in fostering community resilience and positive health outcomes. Social networks will be leveraged to provide resilience, coping mechanisms, and access to treatment and prevention resources. An analysis of substance abuse trends, demographics, and current support services was completed leading to recommendations for enhanced social and peer support systems. The proposed initiative aims for equity, accessibility, and sustainability, while recognizing the challenges of substance abuse, geographics, and privacy concerns. Evidence-based strategies along with stakeholder collaboration aim to achieve the goal of reducing substance abuse rates and improving overall community well-being in Burke County.Master of Public Healt

Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner

Sex differences exist in the hypertrophic response, cardiac remodeling, and transition to heart failure of hypertensive patients, and while some of these differences are likely influenced by estrogen, the genetic pathways downstream of estrogen that impact on cardioprotection have yet to be fully elucidated. We have previously shown that the cardioprotective effects of adrenomedullin (AM), an emerging clinical biomarker for cardiovascular disease severity, vary with sex in mouse models. AM signaling during cardiovascular stress is strongly modulated by receptor activity-modifying protein 3 (RAMP3) via its interaction with the G protein-coupled receptor calcitonin receptor-like receptor (CLR). Like AM, RAMP3 expression is potently regulated by estrogen, and so we sought to determine the consequences of genetic Ramp3 loss on cardiac adaptation to chronic hypertension, with a particular focus on characterizing potential sex differences. We generated and bred RAMP3−/− mice to RenTgMK mice that consistently display severe angiotensin II-mediated CV disease and compared CV disease progression in RenTgMK to that of RenTgMK:RAMP3−/− offspring. As expected, RAMP3 gene expression was higher in cardiovascular tissues of RenTgMK mice and more strongly up-regulated in female RenTgMK mice relative to wildtype controls. RAMP3 loss did not affect the development of hypertension or the presence and severity of perivascular and interstitial fibrosis in the left ventricle (LV). However, echocardiography revealed that while RenTgMK mice developed concentric cardiac hypertrophy with sustained systolic function, male RenTgMK:RAMP3−/− mice showed evidence of LV chamber dilatation and depressed systolic function, suggestive of cardiac decompensation. Consistent with these measures of heart failure, male RenTgMK:RAMP3−/− mice had increased cardiac apoptosis and elevated activation of Akt. These phenotypes were not present in female RenTgMK:RAMP3−/− mice. Collectively, these data demonstrate a sex-dependant, cardioprotective role of RAMP3 in the setting of chronic hypertension

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial

Background: Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to test whether attempting to remove intraventricular haemorrhage with alteplase versus saline irrigation improved functional outcome. Methods: In this randomised, double-blinded, placebo-controlled, multiregional trial (CLEAR III), participants with a routinely placed extraventricular drain, in the intensive care unit with stable, non-traumatic intracerebral haemorrhage volume less than 30 mL, intraventricular haemorrhage obstructing the 3rd or 4th ventricles, and no underlying pathology were adaptively randomly assigned (1:1), via a web-based system to receive up to 12 doses, 8 h apart of 1 mg of alteplase or 0·9% saline via the extraventricular drain. The treating physician, clinical research staff, and participants were masked to treatment assignment. CT scans were obtained every 24 h throughout dosing. The primary efficacy outcome was good functional outcome, defined as a modified Rankin Scale score (mRS) of 3 or less at 180 days per central adjudication by blinded evaluators. This study is registered with ClinicalTrials.gov, NCT00784134. Findings: Between Sept 18, 2009, and Jan 13, 2015, 500 patients were randomised: 249 to the alteplase group and 251 to the saline group. 180-day follow-up data were available for analysis from 246 of 249 participants in the alteplase group and 245 of 251 participants in the placebo group. The primary efficacy outcome was similar in each group (good outcome in alteplase group 48% vs saline 45%; risk ratio [RR] 1·06 [95% CI 0·88–1·28; p=0·554]). A difference of 3·5% (RR 1·08 [95% CI 0·90–1·29], p=0·420) was found after adjustment for intraventricular haemorrhage size and thalamic intracerebral haemorrhage. At 180 days, the treatment group had lower case fatality (46 [18%] vs saline 73 [29%], hazard ratio 0·60 [95% CI 0·41–0·86], p=0·006), but a greater proportion with mRS 5 (42 [17%] vs 21 [9%]; RR 1·99 [95% CI 1·22–3·26], p=0·007). Ventriculitis (17 [7%] alteplase vs 31 [12%] saline; RR 0·55 [95% CI 0·31–0·97], p=0·048) and serious adverse events (114 [46%] alteplase vs 151 [60%] saline; RR 0·76 [95% CI 0·64–0·90], p=0·002) were less frequent with alteplase treatment. Symptomatic bleeding (six [2%] in the alteplase group vs five [2%] in the saline group; RR 1·21 [95% CI 0·37–3·91], p=0·771) was similar. Interpretation: In patients with intraventricular haemorrhage and a routine extraventricular drain, irrigation with alteplase did not substantially improve functional outcomes at the mRS 3 cutoff compared with irrigation with saline. Protocol-based use of alteplase with extraventricular drain seems safe. Future investigation is needed to determine whether a greater frequency of complete intraventricular haemorrhage removal via alteplase produces gains in functional status

Blood flows: mapping journeys of menstrual waste in Blantyre, Malawi

The interplay between menstrual waste and urban sanitation infrastructure is largely hidden from view. Qualitative research has highlighted socio-cultural aspects of menstruation, but few quantitative studies have mapped the physical situation at scale. This study surveyed 258 women in Blantyre, Malawi about their menstrual absorbent choices, disposal practices, and socio-demographic characteristics. A Sankey diagram visualised flows of menstrual waste in the urban environment and identified ultimate disposal points. Most participants used either disposable pads and/or old cloth and disposed of them by either burning and/or throwing in pit latrines. Pad and cloth use were associated with age, education, employment, marital status, and household wealth. Younger women’s preference for disposable pads suggests that demographic shifts may cause volumes of menstrual waste to increase. However, differences in waste volume produced by disposable and reusable absorbents was less than previously assumed. The volume of menstrual waste discarded in pit latrines, and cultural barriers to disposing it elsewhere, highlights challenges for the pit emptying industry and faecal sludge value recovery sector, with the problem anticipated to be most acute in high-density settlements. Widening access to sustainable disposal strategies, affordable reusable menstrual products, and tackling stigma, are key to addressing this social and environmental challenge.Output Status: Forthcoming/Available Onlin