Ciudad educadora: didáctica del patrimonio cultural de los derechos humanos desde una perspectiva controversial. Orientaciones metodológicas de enseñanza y aprendizaje del pasado reciente en el contexto curricular chileno

La siguiente comunicación tiene por objetivo elaborar un conjunto de orientaciones de enseñanza del patrimonio cultural de los Derechos Humanos a través de la articulación teórica y metodológica de la ciudad educadora, los derechos humanos y didáctica del patrimonio cultural desde un enfoque controversial. Se propone una metodología cualitativa a través del uso de fuentes secundarias que para los efectos de esta propuesta, se centrará en: ¿cuáles son las orientaciones didácticas del patrimonio cultural que permiten la enseñanza de los Derechos Humanos para favorecer las ciudadanías memoriales y responsables del pasado reciente heredado? Se constata la necesidad de proponer un tratamiento articulado entre el saber académico y el conocimiento social, potenciando entre los y las estudiantes el desarrollo de aprendizajes para asegurar la salvaguardia consciente de los lugares de memoria desde una ciudadanía activa

Chilean Gastric Cancer Task Force: a study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients

Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region. Trial registration: ClinicalTrials.gov Identifier: NCT03158571, Registered on May 18, 2017