‘Unfettered expression of thought’? Experiences of anonymous online role play

Advocates suggest that anonymity allows all learners to have an equal voice in a learning environment, and that it encourages participation. This paper explores tutors’ and learners’ experiences of an anonymous, synchronous role play activity conducted using online discussion forums. A qualitative study was undertaken to investigate the experiences of five groups of learners and four tutors. Data were obtained from an online questionnaire and interviews with students and tutors. The findings reveal a huge diversity in responses to the activity. Learners’ emotions before the activity ranged from ‘confident’ to ‘panic’. Afterwards many stated that ‘anonymity’ was the best thing about the activity, suggesting that it ‘loosened inhibitions’ and allowed ‘unfettered expression of thought’. At the same time, some respondents admitted trying to guess the identity of participants, and played their roles with varying degrees of conviction and engagement. Some participants may even have refrained from playing any part in the activity, hiding behind their anonymity. For tutors issues of control were significant and issues of facilitation were raised, although inappropriate behaviour was rare. This study has revealed the diversity of learners’ responses to online role play, and the generally positive attitude towards anonymity. It also highlights the potential for anonymity to contribute to inequality in participation and raises the question of whether genuine anonymity can be useful or achievable. Key findings with significance for future implementation of similar role play activities are presented here

Toward a Theory of Thematic Curricula: Constructing New Learning Environments for Teachers & Learners

A theory of thematic curriculum emerged during the development of a unit on pets, entitled Pets & Me. The unit was designed through a school/university partnership for children pre-school to grade 5. Analysis of data collected during the unit\u27s development and field tests supports a dynamic view of curriculum that challenges policy makers to rethink policies that begin from a view of curriculum as a static list of facts to be learned or topics to be mastered. Reflection on the project led to the differentiation of three distinct constructs: (1) facts and information, (2) topics, and (3) themes. Each of these three constructs plays a different role in children\u27s learning. Facts focus on basic information and narrowly defined ideas understood as discrete items. Topics provide a context for facts and information, and present a way of organizing discrete bits of information into classes of experience recognizable by scholars within traditional disciplines. Themes defined as broad existential questions, transcend disciplines, allowing learners to integrate the information and the topic within the full range of human experience. All three are important elements of thematic curriculum

Standardisation of data from real-time quantitative PCR methods – evaluation of outliers and comparison of calibration curves

BACKGROUND: As real-time quantitative PCR (RT-QPCR) is increasingly being relied upon for the enforcement of legislation and regulations dependent upon the trace detection of DNA, focus has increased on the quality issues related to the technique. Recent work has focused on the identification of factors that contribute towards significant measurement uncertainty in the real-time quantitative PCR technique, through investigation of the experimental design and operating procedure. However, measurement uncertainty contributions made during the data analysis procedure have not been studied in detail. This paper presents two additional approaches for standardising data analysis through the novel application of statistical methods to RT-QPCR, in order to minimise potential uncertainty in results. RESULTS: Experimental data was generated in order to develop the two aspects of data handling and analysis that can contribute towards measurement uncertainty in results. This paper describes preliminary aspects in standardising data through the application of statistical techniques to the area of RT-QPCR. The first aspect concerns the statistical identification and subsequent handling of outlying values arising from RT-QPCR, and discusses the implementation of ISO guidelines in relation to acceptance or rejection of outlying values. The second aspect relates to the development of an objective statistical test for the comparison of calibration curves. CONCLUSION: The preliminary statistical tests for outlying values and comparisons between calibration curves can be applied using basic functions found in standard spreadsheet software. These two aspects emphasise that the comparability of results arising from RT-QPCR needs further refinement and development at the data-handling phase. The implementation of standardised approaches to data analysis should further help minimise variation due to subjective judgements. The aspects described in this paper will help contribute towards the development of a set of best practice guidelines regarding standardising handling and interpretation of data arising from RT-QPCR experiments

Systemic treatment of advanced and metastatic urothelial cancer: The landscape in Australia

The 5-year survival rate of metastatic urothelial carcinoma (mUC) is estimated to be as low as 5%. Currently, systemic platinum-based chemotherapy followed by avelumab maintenance therapy is the only first-line treatment for mUC that has an overall survival benefit. Cisplatin-based chemotherapy (usually in combination with gemcitabine) is the preferred treatment but carboplatin is substituted where contraindications to cisplatin exist. Treatment with immune checkpoint inhibitors, antibody-drug conjugates, and kinase inhibitors has not yet demonstrated superiority to chemotherapy as first-line therapy and remains investigational in this setting. A recent media release indicates that chemotherapy plus nivolumab gives an OS advantage as first-line treatment but results of this study have not yet been made public. Pembrolizumab remains an option in those having primary progression on first-line chemotherapy or within 12 months of neoadjuvant chemotherapy. The antibody-drug conjugate, enfortumab vedotin has TGA approval for patients whose cancer has progressed following chemotherapy and immunotherapy and has just received a positive Pharmaceutical Benefits Scheme recommendation. The use of molecular screens for somatic genetic mutations, gene amplifications, and protein expression is expanding as drugs that target such abnormalities show promise. However, despite these advances, a substantial proportion of patients with mUC have significant barriers to receiving any treatment, including advancing age, frailty, and comorbidities, and less toxic, effective therapies are needed

Examining smoking and cessation during pregnancy among an Appalachian sample: a preliminary view

Background Several transitions that a woman experiences prenatally may influence her desire or ability to discontinue smoking. This study explores the role of smoking for young, Appalachian, nulliparous pregnant women and their plans for smoking during their pregnancies. Results The reports of women and their male partners were taken from baseline interviews conducted during the first trimester of pregnancy. Cigarette smoking appeared to be more than an isolated addictive activity; rather, smoking was interwoven in women\u27s social and personal realms, often changing as their perceptions of self changed. Women and their partners who continued to smoke appeared to be depressed, reject authority, and perceived little control over issues related to being pregnant. Conclusion These findings support the argument that standard substance use treatments and polices based on stages-of-change theories may not be effective for all individuals particularly those experiencing significant developmental changes in their lives. Greater success might be obtained from treatment programs designed to recognize the impact of these transitions as it relates to the substance use. The changing experiences of pregnant women in terms of their identity development, views of others, and their relationships have not been adequately addressed in existing cessation programs. Empirically-based interventions targeting these lifestyle characteristics may lead to increased cessation success among pregnant women

Preventable emergency hospital admissions among adults with intellectual disability : comparisons with the general population in England

Purpose Adults with intellectual disabilities (ID) experience poorer physical health and healthcare quality, but there is limited information on the scope for reducing emergency hospital admissions. We describe overall and preventable emergency admissions for adults with ID compared to the general population and assess differences in primary care management before admission for two common Ambulatory Care Sensitive conditions (ACSCs). Methods We used electronic records to study a matched cohort of 16,666 adults with ID and 113,562 age, sex and practice matched controls from 343 English family practices. Incident rate ratios (IRR) from conditional Poisson regression are analysed for all emergency and preventable (ACSC) emergency admissions. Primary care management of lower respiratory (LRTI) and urinary tract (UTI) infections, as exemplar ACSCs, prior to admission are compared in unmatched analysis between adults with and without ID. Results The overall rate for emergency admissions for adults with ID versus controls was 182 vs. 68 per 1000/year (IRR=2.82, 95%CI: 2.66–2.98). ACSCs accounted for 33.7% of emergency admissions compared to 17.3% in controls (IRR=5.62, 5.14-6.13); adjusting for comorbidity, smoking and deprivation did not explain the difference (IRR=3.60, 3.25–3.99). Despite adults with ID being at nearly five times higher risk for admissions from LRTI and UTI, they have similar primary care utilisation, investigation and management preceding admission, as the general population. Conclusion Adults with ID are at high risk of preventable emergency admissions. Identifying improvements for detection and management of ACSCs in primary care, including lower respiratory and urinary tract infections, could reduce hospitalisations