The geography of the cranberry industry in southeastern Massachusetts

The purpose of this paper is to set forth the essential conditions for cranberry growing, to point out the distribution of cranberry bogs in southeastern Massachusetts, to show the adjustment of the industry to natural conditions, to trace the development of the industry in relation to its physical and economic environment, and to predict the future of the industry

Language and Reading Progress of Young Deaf and Hard-of-Hearing Children.

We examined the language and reading progress of 336 young DHH children in kindergarten, first and second grades. Trained assessors tested children's language, reading, and spoken and fingerspelled phonological awareness in the fall and spring of the school year. Children were divided into groups based on their auditory access and classroom communication: a spoken-only group (n = 101), a sign-only group (n = 131), and a bimodal group (n = 104). Overall, children showed delays in language and reading compared to norms established for hearing children. For language, vocabulary standard scores were higher than for English syntax. Although delayed in language, children made expected gains based on hearing norms from kindergarten to second grade. Reading scores declined from kindergarten to second grade. Spoken-only and bimodal children had similar word reading and reading comprehension abilities and higher scores than sign-only children. Spoken-only children had better spoken phonological awareness and nonword reading skills than the other two groups. The sign-only and bimodal groups made similar and significant gains in ASL syntax and fingerspelling phonological awareness

Survival, maturation, fecundity and hatching rates of unablated and ablated Penaeus indicus H.M. Edwards from brackishwater ponds

Penaeus indicus harvested after three months of rearing in brackishwater ponds and averaging 6.9 g for females and 5.6 g for males were stocked in two 12 cu m flowthrough ferrocement tanks at 240 females and 200 males per tank. The females were ablated on one eyestalk in one tank and remained unablated in the other tank; all males were unablated. Ablated females spawned up to 7 times per female; unablated females spawned up to only 3 times during the two month duration of the experiment. Ablated females produced a total number of 17.5 x 106 eggs, 6.6 x 106 nauplii, and an average of 23,480 eggs/spawning and 37.8% hatching rate from a total of 757 spawnings. Unablated females produced a total of 2.0 x 106 eggs, 1.1 x 106 nauplii, and an average of 26.990 eggs/spawning and 53.9% hatching rate from a total of 74 spawnings. Survival of ablated females was 53.5% compared to 69.4% for unablated females; males in both tanks averaged more than 90% survival

Building general practice training capacity in rural and remote Australia with underserved primary care services: a qualitative investigation

Background: Australians living in rural and remote areas have access to considerably fewer doctors compared with populations in major cities. Despite plentiful, descriptive data about what attracts and retains doctors to rural practice, more evidence is needed which informs actions to address these issues, particularly in remote areas. This study aimed to explore the factors influencing General Practitioners (GPs), primary care doctors, and those training to become GPs (registrars) to work and train in remote underserved towns to inform the building of primary care training capacity in areas needing more primary care services (and GP training opportunities) to support their population’s health needs. Methods: A qualitative approach was adopted involving a series of 39 semi-structured interviews of a purposeful sample of 14 registrars, 12 supervisors, and 13 practice managers. Fifteen Australian Medical Graduates (AMG) and eleven International Medical Graduates (IMG), who did their basic medical training in another country, were among the interviewees. Data underwent thematic analysis. Results: Four main themes were identified including 1) supervised learning in underserved communities, 2) impact of working in small, remote contexts, 3) work-life balance, and 4) fostering sustainable remote practice. Overall, the findings suggested that remote GP training provides extensive and safe registrar learning opportunities and supervision is generally of high quality. Supervisors also expressed a desire for more upskilling and professional development to support their retention in the community as they reach mid-career. Registrars enjoyed the challenge of remote medical practice with opportunities to work at the top of their scope of practice with excellent clinical role models, and in a setting where they can make a difference. Remote underserved communities contribute to attracting and retaining their GP workforce by integrating registrars and supervisors into the local community and ensuring sustainable work-life practice models for their doctors. Conclusions: This study provides important new evidence to support development of high-quality GP training and supervision in remote contexts where there is a need for more GPs to provide primary care services for the population

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.

Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets. However, distinguishing the binding of drugs to membrane proteins from that of detergents, lipids and cofactors is challenging. Here, we use high-resolution mass spectrometry to study the effects of HIV protease inhibitors on the human zinc metalloprotease ZMPSTE24. This intramembrane protease plays a major role in converting prelamin A to mature lamin A. We monitored the proteolysis of farnesylated prelamin A peptide by ZMPSTE24 and unexpectedly found retention of the C-terminal peptide product with the enzyme. We also resolved binding of zinc, lipids and HIV protease inhibitors and showed that drug binding blocked prelamin A peptide cleavage and conferred stability to ZMPSTE24. Our results not only have relevance for the progeria-like side effects of certain HIV protease inhibitor drugs, but also highlight new approaches for documenting off-target drug binding