Breeding tools for Cuphea : An updated genetic linkage map and fatty acid mutant candidate gene analysis

Medium chain fatty acids (MCFAs) are important industrial feedstocks for soaps, detergents and surfactants. Interspecific lines derived from Cuphea lanceolata and Cup hea viscosissima are being domesticated as a temperate source of MCFAs. These species also serve as model organisms for understanding the biosynthesis of MCFAs in seeds. Various markers (176 SSRs, 22 fatty acid synthesis loci, and 27 converted RFLP markers) were screened for polymorphism among at least four genotypes (VS55, LN185, LN193-S1, and PSR23). The SSRs had heterozygosities ranging from 0.278 to 0.889. An F2 population ((LN185 x LNI193-S1, 91 individuals) of C. lanceolata (x=6) was genotyped at 90 loci for constructing a genetic linkage map. Eighty eight loci (48 SSRs, 23 SSCPs, 7 SNPs, 10 fatty acid synthesis loci) coalesced into eight linkage groups (two markers segregated independently). The map was 340.8 cM long with a mean density of 3.9 cM per locus. This linkage map will be a useful tool for the continued breeding and domestication of Cuphea

Severe School Phobia

This presentation has emphasized that the under-lying conflict in school phobias begins as bilateral separation anxiety between mother and young child. This unhealthy symbiotic relationship, occurring during the time that the child is trying to develop his own autonomy, cripples his ability to cope with the separation anxiety when he goes to school, or in the face of certain life events such as a move, illness, or birth of a sibling which revive this early anxiety. The response is a disturbed pattern of school attendance which may range from mild to severe and acute to chronic. These basic conflicts represent a neurotic reaction of which child and mother are not aware

Wasted Words?: Current Trends in Collection Development Policies

The transition to electronic resources and the changing role of the collection development librarian are having a tremendous impact on the manner by which libraries select and acquire new materials. The goal of this research project was to further elucidate the current trends of collection development policies in members of the Association of Research Libraries (ARL) as well as gauge current use and future efficacy. The survey was designed and sent to librarians responsible for collection development at university-affiliated ARL libraries in order to obtain a current picture of academic collection development policies, and how they are changing due to the abundance of electronic resources and new methods of data-driven acquisitions. The goals of the survey are to Measure the continued use of CD policies as major collection-building tools; Assess the frequency of updates to collection development policies; Determine the availability of collection development policies; Measure and compare the amount of time available to librarians to review and select new materials; Determine if print materials are being reviewed in new and innovative ways or if they receive the same assessment as electronically formatted materials; Measure the employment of data or patron-driven acquisition methods. The findings will require additional assessment, but the data does seem to indicate a time of change in the way academic libraries complete and assess their primary collection development activities. This survey was created, at least in part, with the hope of setting a starting point for continued evaluation and longitudinal measurement. If our survey participants are as actively helpful in future years, these dreams of cyclical assessment may well come to fruition

The Ursinus Weekly, May 13, 1971

\u2771 CCC forms plans for frosh • H. Salisbury of New York Times to speak at 1971 Commencement • U.C. Sigma Xi chooses new \u2771 members • Campus Chest caps drive with carnival • Application trend up as class of 1975 fills • Area lacrosse squad packed by U.C. girls • Editorial: New McCarthy era on the way? • The cutback • Ursinus grading system often causes problems • Mrs. Gil, Mr. Sorensen leave U.C. faculty • Proposed Limerick power plant presents serious complications • Letters to the editor: J\u27Accuse; Frankly, Scarlett • Movie critic: Father hears no songs • Trackmen finish 7-1 for year; Fourth place in \u2771 MAC meet • Ursinus did it; Beat Swarthmore • Golf team number 10; Peter Allen number 8https://digitalcommons.ursinus.edu/weekly/1146/thumbnail.jp

The Ursinus Weekly, May 20, 1971

U.C. Century II fund drive commences; Goal for \u2770-\u2775 set at 5.5 million • Samuel L. Gandy speaks June 6th • Pancoast takes sabbatical leave • Ursinus gives merit scholarships • Women\u27s curfews change; Weekend hours abolished • What has become of APEs? • Editorial: Apathy kills • Focus: Selby Nera • U.S.G.A. wrap-up 1970-71: A year in pursuit of progress • Appearance & reality? • Double standard is alive and living in Collegeville • Movie critic: Little big man • Student Union and Bomberger renovation to begin soon • Faculty portrait: Dr. Ray Schultz • U.C. English comprehensive to present times-one view • U.C. President William Pettit reflects on past year, his first as President • Mrs. Watson has perfected the art of winning • After four years • Varsity golf: Linksmen finish 6-8 • D. Larson pitches 3 hitter • Final examination schedulehttps://digitalcommons.ursinus.edu/weekly/1147/thumbnail.jp

Forum Report: Issues in the Evaluation of Diagnostic Tests, Use of Historical Controls, and Merits of the Current Multicenter Collaborative Groups

This forum report contains conclusions about 3 different issues relevant to conducting clinical trials in deep mycoses. (1) Trials of diagnostic tests for deep mycoses must define the population appropriate for testing and the clinical question being asked. The unanswered question for the serum Aspergillus galactomannan assay is whether knowledge of results can change use of empirical therapy to treat febrile patients at high risk of invasive aspergillosis. (2) Use of historical controls is suboptimal but offers a pragmatic solution for studying rare mycoses; use of contemporaneous controls, matched for critical variables and evaluated by a blinded data review committee using detailed criteria, appears optimal. (3) Established groups of independent investigators, such as the European Organization for Research on Treatment of Cancer's Invasive Fungal Infections Group and National Institute of Allergy and Infectious Diseases's Bacteriology and Mycology Study Group, provide a pool of experienced investigators, defined operating rules, impartiality, and specialized expertise. Considering the enormous investment required for adequately powered efficacy trials of antifungal agents and the importance of these trials to guide clinical practice, use of collaborative groups outweighs the extra administrative time that is sometimes require

Forum Report: Issues in the Design of Trials of Drugs for the Treatment of Invasive Aspergillosis

A recent trial of drugs for invasive aspergillosis was used as a background for discussing critical features in the design of antifungal trials. The study under discussion allowed stopping either drug without classifying the patient as having treatment failure, so the trial should be understood as a comparison of 2 treatment strategies, not just 2 drugs. Although the study was a noninferiority trial, the outcome permitted a claim of superiority. Use of the category of "probable” in addition to "proven” aspergillosis permitted inclusion of patients for whom the diagnosis was less certain but who were still early enough in the disease progression to respond to therapy. Different opinions still exist about some of the criteria for the diagnosis of "probable” aspergillosis. A blinded data review committee was helpful in evaluating efficacy in this unblinded trial but had limited value in assessing toxicity. An understanding of these features of design of antifungal drug trials is important in applying the results to clinical practic

Forum Report: Issues in Clinical Trials of Empirical Antifungal Therapy in Treating Febrile Neutropenic Patients

There is inferential evidence that some patients with prolonged neutropenia and fever not responding to antibacterial agents are at sufficient risk of deep mycoses to warrant empirical therapy, although superiority of an antifungal agent over placebo has not been conclusively demonstrated. Amphotericin B deoxycholate, liposomal amphotericin B, and intravenous itraconazole followed by oral itraconazole solution are licensed in the United States for this indication. Fluconazole and voriconazole have given favorable results in clinical trials of patients with low and high risk of deep mold infections, respectively. Design features that can profoundly influence outcome of empirical trials are (1) inclusion of low-risk patients, (2) failure to blind the study, (3) obscuration of antifungal effects by changing antibacterial antibiotics, (4) failure to balance both arms of the study in terms of patients with prior antifungal prophylaxis or with severe comorbidities, (5) the merging of end points evaluating safety with those of efficacy, and (6) choice of different criteria for resolution of feve

Antiretroviral Adherence Following Prison Release in a Randomized Trial of the imPACT Intervention to Maintain Suppression of HIV Viremia

Many people living with HIV (PLWH) pass through correctional facilities each year, a large proportion of whom do not maintain viral suppression following release. We examined the effects of imPACT, an intervention designed to promote post-release viral suppression, on antiretroviral therapy (ART) adherence. PLWH awaiting release from prisons in two southern states were randomized to imPACT (consisting of motivational interviewing, care linkage coordination, and text message medication reminders) versus standard care (SC). ART adherence, measured by unannounced monthly telephone pill counts, was compared between study arms over 6 months post-release. Of 381 participants eligible for post-release follow-up, 302 (79%) completed ≥ 1 of 6 possible pill counts (median: 4; IQR 1–6). Average adherence over follow-up was 80.3% (95% CI 77.5, 83.1) and 81.0% (78.3, 83.6) of expected doses taken in the imPACT and SC arms, respectively. There was no difference between arms when accounting for missing data using multiple imputation (mean difference = − 0.2 percentage points [− 3.7, 3.3]), controlling for study site and week of follow-up. Of the 936 (40.9%) pill counts that were missed, 212 (22.7%) were due to re-incarceration. Those who missed pill counts for any reason were more likely to be unsuppressed, suggesting that they had lower adherence. However, missingness was balanced between arms. Among PLWH released from prison, ART adherence averaged > 80% in both study arms over 6 months—a level higher than seen with most other chronic diseases. However, missing data may have led to an overestimate of adherence. Factors independent of the intervention influence ART adherence in this population and should be identified to inform future targeted interventions