Book Reviews

Book Reviews: I Myself Have Seen It: the Myth of Hawai'i by Susanna Moore ; Water And the Law In Hawai'i by Lawrence H. Miike; Aloha Betrayed: Native Hawaiian Resistance To American Colonialism by Noenoe K. Silva ; Completing the Union: Alaska, Hawai'i And the Battle For Statehood by John S. Whitehead; Ku'e: Thirty Years of Land Struggles In Hawai'i by Ed Greevy. Text And Captions by Haunani-Kay Trask; Hawai'is Pineapple Century: A History of the Crowned Fruit In the Hawaiian Islands by Jan K. Ten Bruggencat

Book Reviews

Book Reviews: Ha'ena: Through the Eyes of the Ancestors by Carlos Andrade ; Ben: A Memoir, From Street Kid to Governor by Benjamin J. Cayetano ; Asian Settler Colonialism: From Local Governance to the Habits of Everyday Life in Hawai'i edited by Candace Fujikane and Jonathan Y. Okamura ; Encyclopedia of Islands edited by Rosemary G. Gillespie and David A. Clague ; The Healthy Ancestor: Embodied Inequality and the Revitalization of Native Hawaiian Health by Juliet McMullin ; Alexander Cartwright: The Life Behind the Baseball Legend by Monica Nucciarone ; Island World: A History of Hawai'i and the United States by Gary Y. Okihiro ; A Japanese Robinson Crusoe by Jenichiro Oyabe and edited by Greg Robinson and Yujin Yaguchi ; A Tragedy of Democracy: Japanese Confinement in North America by Greg Robinso

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Book Reviews

Book Reviews: Edward Bailey of Maui: Teacher & Naturalist, Engineer & Artist by Linda McCullough; How Chiefs Became Kings: Divine Kingship and the Rise of Archaic States in Ancient Hawaiÿi by Patrick Vinton Kirch; Pacific Gibraltar: U.S.-Japanese Rivalry Over the Annexation of Hawaiÿi, 1885-1898 by William Michael Morgan; Engineering Nature: Water, Development, & the Global Spread of American Environmental Expertise by Jessica B. Teisch; Organized Agriculture and the Labor Movement Before the UFW: Puerto Rico, Hawaiÿi, California by Dionicio Nodín Valdés; Waves of Resistance: Surfing and History in Twentieth-Century Hawaiÿi by Isaiah Helekunihi Walker; Airborne Dreams: "Nisei" Stewardesses adn Pan American World Airways by Christine R. Yan

Coastal Environments: Mine Discharges and Infringements on Indigenous Peoples’ Rights

Over a century ago, copper mills on the Keweenaw Peninsula of Lake Superior sluiced 64 million metric tonnes (MMT) of tailings into coastal waters, creating a metal-rich “halo”. Here we show that relatively small discharges can spread widely in time and space. Mass Mill (2.9 MMT) dumping into Lake Superior also illustrates the complexity of interactions with Indigenous Peoples. A combination of aerial photos, LiDAR, and a microscope technique for distinguishing end-member particles traces the migration of tailings. The clay fraction spread rapidly across Keweenaw Bay and curled into terminal L’Anse Bay, within tribal Reservation boundaries. The coarse stamp sand fraction moved more slowly southward as a beach sand deposit onto Sand Point, a sacred burial ground. Despite the partial recovery of northern beaches and southern sediments, concerns continue about chemical contamination. Mass Mill provides an excellent example of Indigenous Peoples’ territorial and resource issues with mining. A major difficulty with “legacy” discharges is that there are no longer any “responsible parties”. Initially, federal and state officials were fearful that treaty rights might warrant reparations. Recently, multiple agency/state funding programs supported international (IJC) award-winning restoration efforts by tribal members, illustrating how Indigenous Peoples and governments can work together to safeguard treaty rights

The intense magnetic storm of December 19, 1980: Observations atL= 4

The intense magnetic storm of December 19, 1980 occurred during a major rocket and balloon geophysical research campaign at Siple Station, Antarctica. A balloon flight measuring the electric field and bremsstrahlung X ray flux was conducted during the main phase of the storm. The balloon data and associated ground‐based data from around the world contain several lines of evidence which indicate that the dayside auroral oval expanded to an invariant latitude ≤59° during the storm. Evidence for this conclusion includes (1) the pattern of ground‐based magnetic field and ionospheric electric field perturbations; (2) a substantial departure from the normal diurnal curve of the vertical component of the electric field in the stratosphere; and, (3) identical, relatively rapid equatorward motion of regions of electron precipitation, observed or inferred to occur, simultaneously at three L ∼ 4 stations: Siple, Halley Bay and SANAE, separated by several hours in local time across the dayside. The absence of electron precipitation at Siple after this equatorward motion is an indication that the polar cap had expanded to include Siple during this interval. The power spectra of the magnetic field fluctuations at ULF observed at Siple and in a conjugate latitude chain of magnetometers were consistent with the presence of the dayside auroral oval in the near vicinity of Siple and with the presence of a major magnetospheric boundary slightly equatorward of ∼59°. The stratospheric electric field measured during the recovery phase was very large for this latitude for a period of several hours. This observation suggests that a subauroral latitude ion drift event of unusual intensity and duration accompanied this storm