Scalable Parallel Numerical CSP Solver

We present a parallel solver for numerical constraint satisfaction problems (NCSPs) that can scale on a number of cores. Our proposed method runs worker solvers on the available cores and simultaneously the workers cooperate for the search space distribution and balancing. In the experiments, we attained up to 119-fold speedup using 256 cores of a parallel computer.Comment: The final publication is available at Springe

High strain rate behavior of aluminum die cast components

Abstract Research results of static and dynamic mechanical tests (ɛ = 1 * 10-3 s-1 and ɛ ~ 5 * 102 s-1 conducted on samples obtained from three different die cast products (component A, B and C) of AlSi10MnMg alloy are reported. All the components have thin-walled geometry except some thicker positions of component C. The dynamic (high strain rate) mechanical characterization shows an increase of tensile properties, in respect to static tensile ones (tensile strength increases approximately 15%, and the yield strength 30%, for all the die cast components) together with an evident plastic deformation, with consequent necked region in the fractured section, substantially negligible in case of static tensile tests. Moreover, fractographic observations are conducted on specimens undergone static and high strain rate test conditions, to observe the fracture morphology, together with metallographic analysis on the only polished or etched transverse specimens to reveal the porosity, and the microstructure of dendrite and inter-dendrite morphologies

Improvement of resveratrol permeation through sublingual mucosa: Chemical permeation enhancers versus spray drying technique to obtain fast-disintegrating sublingual mini-tablets

Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed by direct compression. Since RSV by itself exhibits a low permeation aptitude, this could be significantly enhanced by the use of CPEs as well as by embedding RSV in a spray-dried powder to be compressed in order to prepare fast-disintegrating mini-tablets. The most promising observed CPEs (menthol, lysine and urea) were then inserted into the most promising spray-dried excipients’ compositions (RSV-B and RSV-C), thus preparing CPE-loaded mini-tablets. However, this procedure leads to unsatisfactory results which preclude the possibility of merging the two proposed approaches. Finally, the best spray-dried composition (RSV-B) was further evaluated by SEM, FTIR, XRD and disintegration as well as dissolution behavior to prove its effectiveness as a sublingual fast-disintegrating formulation

Androgenetic alopecia: a review

Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism of androgenetic alopecia.Using the PubMed database, we conducted a systematic review of the literature, selecting studies published from 1916 to 2016.The occurrence and development of androgenetic alopecia depends on the interaction of endocrine factors and genetic predisposition. Androgenetic alopecia is characterized by progressive hair follicular miniaturization, caused by the actions of androgens on the epithelial cells of genetically susceptible hair follicles in androgen-dependent areas. Although the exact pathogenesis of androgenetic alopecia remains to be clarified, research has shown that it is a polygenetic condition. Numerous studies have unequivocally identified two major genetic risk loci for androgenetic alopecia, on the X-chromosome ARa"EDA2R locus and the chromosome 20p11 locus.Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms at different genomic loci are associated with androgenetic alopecia development. A number of genes determine the predisposition for androgenetic alopecia in a polygenic fashion. However, further studies are needed before the specific genetic factors of this polygenic condition can be fully explained

On the evaluation of some three-body variational integrals

Stable recursive relations are presented for the numerical computation of the integrals $$\int d{\bf r}_1 d{\bf r}_2 r_1^{l-1} r_2^{m-1} r_{12}^{n-1} \exp{\{-\alpha r_1 -\beta r_2 -\gamma r_{12}\}}$$ ($l$, $m$ and $n$ integer, $\alpha$, $\beta$ and $\gamma$ real) when the indices $l$, $m$ or $n$ are negative. Useful formulas are given for particular values of the parameters $\alpha$, $\beta$ and $\gamma$.Comment: 12 pages, 1 figure (PS) and 3 tables. Old figures 2 and 3 replaced by Tables I and III. A further table added. Paper enlarged giving some tips on the convergence of quadrature

Environmental and socio-economic effects of construction and demolition waste recycling in the European Union

The recovery rate of construction and demolition waste (CDW) in the European Union (EU) is at 89 % and thus high relative to other waste streams. However, the relatively high figure can be misleading because it typically does not correspond to high-value material recovery but rather "poor" levels of circularity. From a life-cycle perspective, we assess the environmental impacts and costs of 12 CDW material fractions relying on alterna-tive pathways and treatment technologies. The results indicate important trade-offs in the transition towards the circular economy. Indeed, recycling of concrete, bricks, gypsum, and ceramics and tiles represent the best environmental performance but also the most expensive pathway. However, when shifting from landfill to recycling the total societal costs in the EU are reduced mainly due to the lower external costs. Overall, recycling CDW in the EU with advanced technologies would save about 264 kg CO2-eq t(-1) with a cost of 25 EUR t(-1). The maximum potential for recycling under current technology in the EU would lead to an annual total reduction of about 33 Mt. of CO2-eq using 2020 as reference year. The fractions with the highest potential for improving current waste management practices in terms of environmental improvements are concrete and bricks. The economic and non-economic barriers for realising this potential at EU level are discussed in relation to the European Green Deal and the EU's circular economy objectives