A high-Q InP resonant angular velocity sensor for a monolithically integrated optical gyroscope

\u3cp\u3eThe design, fabrication, and optical characterization of the sensing element of a photonic InP-based gyroscope intended for applications in the field of aerospace and defense are reported in this paper. The sensing element is a spiral resonator coupled to a straight bus waveguide through a multimode interference coupler and exhibits a Q factor of approximately 600000 with a footprint of approximately 10 mm\u3csup\u3e2\u3c/sup\u3e. The design of each component of the sensor is based on some well-established numerical methods such as the Finite Element Method, the beam propagation method, and the film mode matching method. The spiral cavity was designed using the standard transfer matrix method. The selected fabrication process, which is an enhanced version of the standard COBRA process, allows the monolithic integration of the sensing element with the other active components of the gyroscope, e.g., lasers, photodiodes, and modulators. Each component of the fabricated sensing element was optically characterized using an appropriate setup, which was also used for the optical characterization of the whole sensor. Based on the results of the characterization, the gyro performance was evaluated, and a way to improve both the resolution and the bias drift, i.e., down to 10 °/h and 1 °/h, respectively, was also clearly identified. The achieved results demonstrate, for the first time, the actual feasibility of a photonic gyro-on-chip through a well-established InP-based generic integration process.\u3c/p\u3

Clinical and genetic analyses of familial and sporadic frontotemporal dementia patients in Southern Italy

Introduction We investigated the clinical differences between familial and sporadic frontotemporal dementia (FTD), screening for mutations in known FTD genes. Methods We diagnosed 22 affected individuals belonging to eight families and 43 sporadic cases with FTD in Apulia, Southern Italy, in 2 years. Mutations in common causative FTD genes (GRN, MAPT, VCP, and TARDBP) and C9ORF72 expansions were screened. Results Behavioral variant of FTD was the most common clinical subtype (50% and 69% in familial and sporadic cases, respectively). Social conduct impairment/disinhibition, loss of insight, and inflexibility were the most frequent clinical features observed at onset. One new mutation was identified in GRN in family A. Discussion Disease onset in sporadic FTD was more frequently characterized by a clustering of behavioral symptoms with apathy and loss of personal hygiene. Mutations in common causative FTD genes are not a major cause of familial and sporadic FTD in the Southern Italian population

An observational study of functional abilities in infants, children, and adults with type 1 SMA

ObjectiveTo report cross-sectional clinical findings in a large cohort of patients affected by type 1 spinal muscular atrophy.MethodsWe included 122 patients, of age ranging between 3 months and 22 years, 1 month. More than 70% (85/122) were older than 2 years and 25% (31/122) older than 10 years. Patients were classified according to the severity of phenotype and to the number of SMN2 copies.ResultsPatients with the more common and the most severe phenotype older than 2 years were, with few exceptions, on noninvasive ventilation and, with increasing age, more often had tracheostomy or >16-hour ventilation and a gastrostomy inserted. In contrast, 25 of the 28 patients with the mildest phenotype older than 2 years had no need for tracheostomy or other ventilatory or nutritional support. In patients older than 2 years, the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scores were generally lower compared to those found in younger patients and showed distinct levels of functional abilities according to the severity of the phenotype. Similar findings were also observed on the Hammersmith Infant Neurological Examination.ConclusionsOur findings confirm that, after the age of 2 years, patients with type 1 spinal muscular atrophy generally survive only if they have gastrostomy and tracheostomy or noninvasive ventilation >16 hours and have low scores on the functional scales. More variability, however, can be expected in those with the mildest phenotype, who achieve head control. These data provide important baseline information at the time treatments are becoming available