3D Biomimetic Platform

An apparatus and method that utilizes a radiation source and a simulated microgravity to provide combined stressors. The response of cells/bacteria/viruses and/or other living matter to the combined stressors can be evaluated to predict the effects of extended space missions. The apparatus and method can also be utilized to study diseases and to develop new treatments and vaccinations

Responding to the maternal health care challenge: The Ethiopian Health Extension Program

Background: Responding to challenges in achieving Millennium Development Goals (MDG), the Ethiopian government initiated the Health Extension Program in 2003 as part of the Health Sector Development Program (HSDP) to improve equitable access to preventive, promotive and select curative health interventions through paid community level health extension workers.Objective: To explore Ethiopia’s progress toward achieving MDG 5 that focuses on improved maternal health through the Health Extension Program.Methods: This paper reviews available survey data and literature to determine the feasibility of reaching the targets specified for MDG 5 and for HSDP.Important findings: Achieving the set targets is a daunting task despite reaching the physical targets of two health extension workers per kebele. The 2015 MDG target for the Maternal Mortality Ratio (MMR) is 218 while the 2005 MMR estimate is 673. The HSDP target is 32% skilled birth attendant use by 2010 but only about 12% use was found in the four most populated regions of the country in 2009.Conclusions: Accelerating progress towards these targets is possible through the Health Extension Program at the worker level through improved promotion of family planning and specific maternal interventions, such as misoprostol for active management of third stage of labor, immediate postpartum visits, and improved coordination from community to referral level. [Ethiop. J. Health Dev. 2010;24 Special Issue 1:105-109

Programmatic correlates of maternal healthcare seeking behaviors in Ethiopia

Background: Considerable improvement in maternal healthcare use has been observed since the inception of the health extension program (HEP) in Ethiopia in 2003.Objective: This paper evaluates the influence of HEP outreach strategies on maternal healthcare use.Method: Cross-sectional survey of 2,916 women with children 0 to 11 months from Amhara, Oromiya, Southern Nations, Nationalities and People’s, and Tigray regions, obtained between December 2008 and January 2009, were analyzed using regression models to assess the impacts of HEP strategies on maternal health outcomes.Result: The analyses found that communities (i.e., kebeles) with relatively high prevalence of model families, higher rate of household visits by health extension workers, and higher rate of household visits by voluntary community health workers were associated with improved antenatal care use, tetanus toxoid vaccination coverage, and receiving postnatal care visits; but the strategies were not associated with deliveries attended by health professionals.Conclusion: Although the impacts of HEP strategies on maternal healthcare use were statistically significant, they were not optimum to reach the maternal mortality reduction targets of the government of Ethiopia. The HEP needs to review and strengthen its community based strategies in order to reach its goals. [Ethiop. J. Health Dev. 2010;24 Special Issue 1:92-99

IBM Watson Supporting Space Radiation

The NASA Human Research Program (HRP) Space Radiation (SR) Program Element has been working with IBM Watson Explorer (WEX) to create a tool that allows researchers to search the NASA SR-funded research corpus to help streamline research and maximize efficiency. The entire corpus of publications from research funded by the NASA SR Program Element has been ingested into WEX to allow for examination of: synergies across funded research areas, gaps in research, and collaboration opportunities. This information will be valuable to both scientists and managers as it will allow analysis related to specific scientific questions, inform key decisions and support cross validation of study results. NASA will also evaluate the potential to make WEX publicly available in order to facilitate proposal generation and to enhance collaborations within and across disciplines

Nitrogen deposition in Northern Ireland and import/export of N deposition across the UK.

Atmospheric nitrogen (N) deposition represents a significant threat to sensitive habitats and species in the United Kingdom, with excessive N supply leading to declines in many important species of high conservation value, at the expense of fast-growing species that can exploit the additional nitrogen supply. Atmospheric N is produced from emissions of ammonia (NH3, mainly from agricultural sources) and nitrogen oxides (NOx, mainly from transport, industry, power generation and other combustion sources). This report aims to quantify and compare N deposition to land in NI from sources within NI and overseas (in the UK, Republic of Ireland, Shipping and the rest of Europe) to the amount of N deposition produced from NI sources that is deposited overseas. Estimating the likely source of N deposition received by NI will allow enable policy makers to assess how effective national N mitigation measures are likely to be. This study shows that Northern Ireland exports more atmospheric N deposition to the rest of the UK than it receives (from the UK and elsewhere). The amount of N originating from sources within NI and deposited within NI is mostly from NH3 emission sources (92%), with only 8% due to NOx emissions. These atmospheric N inputs produced within the country are the fraction that can be tackled with NI-internal policy development. When taking into account atmospheric N input from all sources (NI-internal and beyond), a substantial proportion of the NHx deposition is from sources within NI, while NOx deposition may be harder to tackle with a substantial proportion coming from the UK, Republic of Ireland and the rest of Europe, including shipping

2018 Estimates of nitrogen deposition in Northern Ireland and import/export of N deposition across the UK.

Atmospheric nitrogen (N) deposition represents a significant threat to sensitive habitats and species in the United Kingdom, with excessive N supply leading to declines in many important species of high conservation value, at the expense of fast-growing species that can exploit the additional nitrogen supply. Atmospheric N deposition originates from emissions of ammonia (NH3, mainly from agricultural sources) and nitrogen oxides (NOx, mainly from transport, industry, power generation and other combustion sources). This short report aims to update the import and export estimates of atmospheric nitrogen to/from Northern Ireland by Carnell et al. (2020). More up to date estimates of N deposition to/from Northern Ireland now exist for the emission year 2018, which were developed under the Air Pollution Information System (APIS http://www.apis.ac.uk/) project and funded by the UK government agencies (SEPA, SNH, JNCC, EA, NE, NRW, NIEA). This report aims to quantify and compare N deposition to land in NI from sources within NI and beyond (in the UK, Republic of Ireland, Shipping and mainland Europe) to the amount of N deposition produced from NI sources that is deposited to the rest of the UK. Estimating the likely source of N deposition received by NI will enable policy makers to assess how effective national N mitigation measures are likely to be

Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life

Excess weight gained during the early years and, in particular, rapid weight gain in the first 2 years of life, are a major risk factors for adult obesity. The growing consensus is that childhood obesity develops from a complex interaction between genetic susceptibility and exposure to an 'obesogenic' environment. Behavioural susceptibility theory (BST) was developed to explain the nature of this gene-environment interaction, and why the 'obesogenic' environment does not affect all children equally. It hypothesizes that inherited variation in appetite, which is present from birth, determines why some infants and children overeat, and others do not, in response to environmental opportunity. That is, those who inherit genetic variants promoting an avid appetite are vulnerable to overeating and developing obesity, while those who are genetically predisposed to have a smaller appetite and lower interest in food are protected from obesity-or even at risk of being underweight. We review the breadth of research to-date that has contributed to the evidence base for BST, focusing on early life, and discuss implications and future directions for research and theory. This article is part of a discussion meeting issue 'Causes of obesity: theories, conjectures and evidence (Part I)'

Aligned and Electrospun Piezoelectric Polymer Fiber Assembly and Scaffold

A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound

Aligned and Electrospun Piezoelectric Polymer Fiber Assembly and Scaffold

A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound