Synthesis and transfection properties of a series of lipidic neamine derivatives

International audienceWith the view to develop novel bioinspired nonviral vectors for gene delivery, we synthesized a series of cationiclipids with a neamine headgroup, which incorporates rings I and II of the natural antibiotic aminoglycoside neomycin B. Indeed, we reasoned that neamine might constitute a straightforward and versatile building block for synthesizing a variety of lipophilic aminoglycosides and modulating their characteristics such as size, topology, lipophilicity, number of charges, and charge density. Neamine derivatives bearing long dialkyl chains, one or two neamine headgroups, and four to ten protonatable amine functions were prepared through the selective alkylation of the 4′- or 5-hydroxyl function in ring I and ring II of neamine, respectively. The transfection activity of the twelve derivatives synthesized was investigated in Vitro in gene transfection experiments using several mammalian cell lines. The results allowed us to unveil interesting structure-activity relationships and to identify a formulation incorporating a small neamine derivative as a highly efficient gene delivery system

Liberal intervention in the foreign policy thinking of Tony Blair and David Cameron

David Cameron was a critic of Tony Blair’s doctrine of the international community, which was used to justify war in Kosovo and more controversially in Iraq, suggesting caution in projecting military force abroad while in opposition. However, and in spite of making severe cuts to the defence budget, the Cameron-led Coalition government signed Britain up to a military intervention in Libya within a year of coming into office. What does this say about the place liberal interventionism occupies in contemporary British foreign policy? To answer this question, this article studies the nature of what we describe as the ‘bounded liberal’ tradition that has informed British foreign policy thinking since 1945, suggesting that it puts a distinctly UK national twist on conventional conservative thought about international affairs. Its components are: scepticism of grand schemes to remake the world; instinctive Atlanticism; security through collective endeavour; and anti-appeasement. We then compare and contrast the conditions for intervention set out by Tony Blair and David Cameron. We explain the similarities but crucially also the vital differences between the two leaders’ thinking on intervention, with particular reference to Cameron’s perception that Downing Street needed to loosen its control over foreign policy-making after Iraq. Our argument is that policy substance, policy style and party political dilemmas prompted Blair and Cameron to reconnect British foreign policy with its ethical roots, ingraining a bounded liberal posture to British foreign policy after the moral bankruptcy of the John Major years. This return to a patient, pragmatic and ethically informed foreign policy meant that military operations in Kosovo and Libya were undertaken in quite different circumstances, yet came to be justified by similar arguments from the two leaders

La banque du XXIe siècle : Etats-Unis, Grande-Bretagne, Japon, France

251 p., tabl., ref. bib. : 1 p.3/4La décennie écoulée a vu l'environnement bancaire et financier se modifier en profondeur. Où en est-on aujourd'hui ? Quel sera dans les années à venir le destin d'un des plus anciens commerces du monde, celui de l'argent ? Faisant le point sur l'état de la banque-industrie en France aussi bien que sur les évolutions récentes aux États-Unis, à Londres ou au Japon, ainsi que dans des pays en pleine expansion comme la Chine, Hervé de Carmoy diagnostique l'émergence d'un nouveau modèle bancaire, la « Banque-Dividende », axé sur la transparence, la rigueur, la rentabilité et l'obsession du client. Un instrument indispensable pour les professionnels comme pour les étudiants

Robert Rothschild. Les chemins de Munich : une nuit de sept ans. 1932-1939

De Carmoy Guy. Robert Rothschild. Les chemins de Munich : une nuit de sept ans. 1932-1939. In: Politique étrangère, n°2 - 1989 - 54ᵉannée. p. 367

Les Etats-Unis face au défi de l'énergie

De Carmoy Guy. Les Etats-Unis face au défi de l'énergie. In: Politique étrangère, n°5 - 1977 - 42ᵉannée. pp. 487-516

Robert Rothschild. Les chemins de Munich : une nuit de sept ans. 1932-1939

De Carmoy Guy. Robert Rothschild. Les chemins de Munich : une nuit de sept ans. 1932-1939. In: Politique étrangère, n°2 - 1989 - 54ᵉannée. p. 367

Les organisations professionnelles et l'expansion économique régionale

De Carmoy Guy. Les organisations professionnelles et l'expansion économique régionale. In: Revue française de science politique, 6ᵉ année, n°2, 1956. pp. 277-290