6 research outputs found
Large Scale Pressure Fluctuations and Sunyaev-Zel'dovich Effect
The Sunyaev-Zel'dovich (SZ) effect associated with pressure fluctuations of
the large scale structure gas distribution will be probed with current and
upcoming wide-field small angular scale cosmic microwave background
experiments. We study the generation of pressure fluctuations by baryons which
are present in virialized dark matter halos and by baryons present in small
overdensities. For collapsed halos, assuming the gas distribution is in
hydrostatic equilibrium with matter density distribution, we predict the
pressure power spectrum and bispectrum associated with the large scale
structure gas distribution by extending the dark matter halo approach which
describes the density field in terms of correlations between and within halos.
The projected pressure power spectrum allows a determination of the resulting
SZ power spectrum due to virialized structures. The unshocked photoionized
baryons present in smaller overdensities trace the Jeans-scale smoothed dark
matter distribution. They provide a lower limit to the SZ effect due to large
scale structure in the absence of massive collapsed halos. We extend our
calculations to discuss higher order statistics, such as bispectrum and
skewness in SZ data. The SZ-weak lensing cross-correlation is suggested as a
probe of correlations between dark matter and baryon density fields, while the
probability distribution functions of peak statistics of SZ halos in wide field
CMB data can be used as a probe of cosmology and non-Gaussian evolution of
large scale structure pressure fluctuations.Comment: 16 pages, 9 figures; Revised with expanded discussions. Phys. Rev. D.
(in press
Constraining the dark energy with galaxy clusters X-ray data
The equation of state characterizing the dark energy component is constrained
by combining Chandra observations of the X-ray luminosity of galaxy clusters
with independent measurements of the baryonic matter density and the latest
measurements of the Hubble parameter as given by the HST key project. By
assuming a spatially flat scenario driven by a "quintessence" component with an
equation of state we place the following limits on the
cosmological parameters and : (i) and (1) if the
equation of state of the dark energy is restricted to the interval (\emph{usual} quintessence) and (ii) and
() if violates the null energy condition and assume values (\emph{extended} quintessence or ``phantom'' energy). These results are in
good agreement with independent studies based on supernovae observations,
large-scale structure and the anisotropies of the cosmic background radiation.Comment: 6 pages, 4 figures, LaTe
Astronomical Distance Determination in the Space Age: Secondary Distance Indicators
The formal division of the distance indicators into primary and secondary leads to difficulties in description of methods which can actually be used in two ways: with, and without the support of the other methods for scaling. Thus instead of concentrating on the scaling requirement we concentrate on all methods of distance determination to extragalactic sources which are designated, at least formally, to use for individual sources. Among those, the Supernovae Ia is clearly the leader due to its enormous success in determination of the expansion rate of the Universe. However, new methods are rapidly developing, and there is also a progress in more traditional methods. We give a general overview of the methods but we mostly concentrate on the most recent developments in each field, and future expectations. © 2018, The Author(s)
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent glioma and its microenvironment are characterized by a senescent-like state of mitotic arrest and a senescence-associated secretory phenotype (SASP) induced by prior chemoradiation. Although senescence was once thought to be irreversible, recent evidence has demonstrated that cells may escape this state and re-enter the cell cycle, contributing to tumor recurrence. Moreover, senescent tumor cells could spur the growth of their non-senescent counterparts, thereby accelerating recurrence. In this review, we highlight emerging evidence supporting the use of senolytic agents to ablate latent, senescent-like cells that could contribute to tumor recurrence. We also discuss how senescent cell clearance can decrease the SASP within the tumor microenvironment thereby reducing tumor aggressiveness at recurrence. Finally, senolytics could improve the long-term sequelae of prior therapy on cognition and bone marrow function. We critically review the senolytic drugs currently under preclinical and clinical investigation and the potential challenges that may be associated with deploying senolytics against latent glioma. In conclusion, senescence in glioma and the microenvironment are critical and potential targets for delaying or preventing tumor recurrence and improving patient functional outcomes through senotherapeutics