Histoplasmose como causa de perfuração intestinal em paciente com síndrome da imunodeficiência adquirida

Thirty-four years old patient, female, husband died of AIDS (Acquired Immunodeficiency Síndrome). She's confined to Hospital Universitário João de Barros Barreto, with a positive tesT for AIDS, fever, 10 kg/month of weight loss, diarrhea with gummy faeces, productive cough, yellowish sputum. The therapy was initiated, symptomatic, associated to Epivir, Saquinavir and AZT. The searching exams for Alcohol Ácid Resistant Bacili and fungi in the sputum were negative. At the hemogram was shown a pancytopenia, the esophagogastroduodenunscopy showed light esophago moniliasis. During commitment presented a perforating acute abdomen chart, the abdominal radiography showed hidroair levels, pneumoperitoneum, enlarced bowels with swollen wall. She was undertaken a surgery with diagnosis hypothesis of cytomegalovirus perforation, which accordin to literature is the most frequent cause of intestinal perforation in patients with AIDS

Lymphocyte proliferation stimulated by activated Cebus apella macrophages treated with a complex homeopathic immune response modifiers

Introduction: Canova is a complex homeopathic medicine that enhances a specific immunologic responses against several exogenous and endogenous conditions. Canova activates macrophages both in vivo and in vitro.Aim and method: We evaluated the effects of macrophages activated by Canova in vivo and ex vitro in the proliferation of lymphocytes. Canova was used to activate Cebus apella macrophages in vivo or ex vitro with Canova. Lymphocytes were cultured with the macrophage culture medium. the analysis of Canova effects in cultured lymphocytes was performed according to the cell cycle phase using flow cytometry. the Interferon gamma and Interleukin-5 cytokines quantification in these lymphocyte culture media was performed by Enzyme-linked immunosorbent assay (ELISA).Results: We observed that Canova actives macrophages in vivo and ex vitro. the lymphocytes cultured in a supplemented medium with macrophages activated by Canova treatment presented a higher number of proliferation cells than lymphocytes not exposed to macrophages activated by Canova. the Interferon gamma and Interleukin-5 cytokines were only observed in the medium of lymphocytes exposed to macrophages activated by Canova. Thus, Canova has potential as a new adjuvant therapy. Homeopathy (201 2) 101, 74-79.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Discipline Genetica, Dept Morfol & Genetica, BR-04023900 São Paulo, BrazilFed Univ Para, Lab Citogenetica Humana, Inst Ciencias Biol, BR-66059 Belem, PA, BrazilFed Univ Para, Serv Cirurgia, Hosp Univ Joao de Barros Barreto, BR-66073000 Belem, PA, BrazilMinist Saude, Ctr Nacl Primatas, BR-77030000 Ananindeua, PA, BrazilUniversidade Federal de São Paulo, Discipline Genetica, Dept Morfol & Genetica, BR-04023900 São Paulo, BrazilCNPq: 550885/2007-2CNPq: 302774/2009-2CNPq: 301609/2007-1FAPESP: 2007/02470-3Web of Scienc