571 research outputs found
Silvia, P. J. (2011). Cómo escribir mejores textos académicos: Guía Práctica. (1ª reimp.). (Solís Bravo, A, Trad.). México: El Manual Moderno. Pp. 127.
Source-Frequency Phase-Referencing Observation of AGNs with KaVA Using Simultaneous Dual-Frequency Receiving
The KVN(Korean VLBI Network)-style simultaneous multi-frequency receiving
mode is demonstrated to be promising for mm-VLBI observations. Recently, other
Very long baseline interferometry (VLBI) facilities all over the globe start to
implement compatible optics systems. Simultaneous dual/multi-frequency VLBI
observations at mm wavelengths with international baselines are thus possible.
In this paper, we present the results from the first successful simultaneous
22/43 GHz dual-frequency observation with KaVA(KVN and VERA array), including
images and astrometric results. Our analysis shows that the newly implemented
simultaneous receiving system has brought a significant extension of the
coherence time of the 43 GHz visibility phases along the international
baselines. The astrometric results obtained with KaVA are consistent with those
obtained with the independent analysis of the KVN data. Our results thus
confirm the good performance of the simultaneous receiving systems for the
non-KVN stations. Future simultaneous observations with more global stations
bring even higher sensitivity and micro-arcsecond level astrometric
measurements of the targets.Comment: 8 pages, 6 figures, Published in JKA
Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus
BACKGROUND: Methicillin-resistant S. aureus (MRSA) with low susceptibility to glycopeptides is uncommon. CASE PRESENTATION: The case of a 50-year-old non-drug addict patient presenting with tricuspid valve infective endocarditis (IE) by MRSA resistant to vancomycin and linezolid is presented. There was response only to quinupristin/dalfopristin. He had a motorcycling accident four years before undergoing right above-the-knee amputation and orthopaedic fixation of the left limb. There were multiple episodes of left MRSA-osteomyelitis controlled after surgery and vancomycin therapy. MRSA isolated from the blood at the time of IE presented with the same profile than the isolated four years earlier. Sequential treatment with teicoplanin-cotrimoxazole and Linezolid associated to vancomycin – rifampicin – cotrimoxazole had no improvement. Infection was controlled after 28 days of therapy with quinupristin/dalfopristin. CONCLUSION: The literature presents only a few cases of MRSA IE not susceptible to glycopeptides in not drug addicted patients. This case shows the comparison of a highly-resistant MRSA after previous S. aureus osteomyelitis treated with glycopeptides. This is the first description of successful treatment of resistant-MRSA IE of the tricuspid valve complicated by multiple pulmonary septic infarction with quinupristin/dalfopristi
Pilot KaVA monitoring on the M87 jet: confirming the inner jet structure and superluminal motions at sub-pc scales
We report the initial results of our high-cadence monitoring program on the
radio jet in the active galaxy M87, obtained by the KVN and VERA Array (KaVA)
at 22 GHz. This is a pilot study that preceded a larger KaVA-M87 monitoring
program, which is currently ongoing. The pilot monitoring was mostly performed
every two to three weeks from December 2013 to June 2014, at a recording rate
of 1 Gbps, obtaining the data for a total of 10 epochs. We successfully
obtained a sequence of good quality radio maps that revealed the rich structure
of this jet from <~1 mas to 20 mas, corresponding to physical scales
(projected) of ~0.1-2 pc (or ~140-2800 Schwarzschild radii). We detected
superluminal motions at these scales, together with a trend of gradual
acceleration. The first evidence for such fast motions and acceleration near
the jet base were obtained from recent VLBA studies at 43 GHz, and the fact
that very similar kinematics are seen at a different frequency and time with a
different instrument suggests these properties are fundamental characteristics
of this jet. This pilot program demonstrates that KaVA is a powerful VLBI array
for studying the detailed structural evolution of the M87 jet and also other
relativistic jets.Comment: 10 pages, 9 figures, accepted for publication in PAS
Convalescent Pulmonary Dysfunction Following Hantavirus Pulmonary Syndrome in Panama and the United States
The objective of this study was to document persistent pulmonary symptoms and pulmonary function abnormalities in adults surviving hantavirus pulmonary syndrome (HPS). Acute infection by most hantaviruses result in mortality rates of 25–35%, while in Panama the mortality rate of 10% is contrasted by an unusually high incidence. In all types of HPS, the viral prodrome, cardiopulmonary phase due to massive pulmonary capillary leak syndrome, and spontaneous diuresis are followed by a convalescent phase with exertional dyspnea for 3–4 weeks, but the frequency of persistent symptoms is not known. In this observational study of a convenience sample, 14 survivors of HPS caused by Choclo virus infection in Panama and 9 survivors of HPS caused by Sin Nombre virus infection in New Mexico completed a questionnaire and pulmonary function tests up to 8 years after infection. In both groups, exertional dyspnea persisted for 1–2 years after acute infection in 43% (Panama) and 77% (New Mexico) of survivors surveyed. Reduction in midexpiratory flows (FEF25–75%), increased residual volume (RV), and reduced diffusion capacity (DLCO/VA) also were common in both populations; but the severity of reduced expiratory flow did not correlate with exertional dyspnea. Symptoms referable to previous hantavirus infection had resolved within 3 years of acute infection in most but not all patients in the Panama group. Temporary exertional dyspnea and reduced expiratory flow are common in early convalescence after HPS but resolves in almost all patients
From Amazon rain forest flora to the state-of-the-art technology devices, the incessant search for 'magic bullets' against Streptococcus mutans
Bevacizumab plus paclitaxel versus placebo plus paclitaxel as first-line therapy for HER2-negative metastatic breast cancer (MERiDiAN): A double-blind placebo-controlled randomised phase III trial with prospective biomarker evaluation
Aim: MERiDiAN evaluated plasma vascular endothelial growth factor-A (pVEGF-A) prospectively as a predictive biomarker for bevacizumab efficacy in metastatic breast cancer (mBC).
Methods: In this double-blind placebo-controlled randomised phase III trial, eligible patients had HER2-negative mBC previously untreated with chemotherapy. pVEGF-A was measured
before randomisation to paclitaxel 90 mg/m2 on days 1, 8 and 15 with either placebo or bevacizumab 10 mg/kg on days 1 and 15, repeated every 4 weeks until disease progression, unacceptable toxicity or consent withdrawal. Stratification factors were baseline pVEGF-A, prior adjuvant chemotherapy, hormone receptor status and geographic region. Co-primary endpoints were investigator-assessed progression-free survival (PFS) in the intent-to-treat and pVEGF-Ahigh populations.
Results: Of 481 patients randomised (242 placeboepaclitaxel; 239 bevacizumabepaclitaxel), 471 received study treatment. The stratified PFS hazard ratio was 0.68 (99% confidence interval, 0.51e0.91; log-rank p Z 0.0007) in the intent-to-treat population (median 8.8 months with placeboepaclitaxel versus 11.0 months with bevacizumabepaclitaxel) and 0.64 (96% con-fidence interval, 0.47e0.88; log-rank p Z 0.0038) in the pVEGF-Ahigh subgroup. The PFS treatment-by-VEGF-A interaction p value (secondary end-point) was 0.4619. Bevacizumab was associated with increased incidences of bleeding (all grades: 45% versus 27% with placebo),
neutropenia (all grades: 39% versus 29%; grade 3: 25% versus 13%) and hypertension (all grades: 31% versus 13%; grade 3: 11% versus 4%).
Conclusion: The significant PFS improvement with bevacizumab is consistent with previous placebo-controlled first-line trials in mBC. Results do not support using baseline pVEGF-A
to identify patients benefitting most from bevacizumab.
Clinical trials registration: ClinicalTrials.gov NCT01663727
Comparison beetwen open and laparoscopic radical cistectomy in a latin american reference center: perioperative and oncological results
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