Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair

Contains fulltext : 169649.pdf (publisher's version ) (Open Access)Skin wounds may lead to scar formation and impaired functionality. Remote ischemic preconditioning (RIPC) can induce the anti-inflammatory enzyme heme oxygenase-1 (HO-1) and protect against tissue injury. We aim to improve cutaneous wound repair by RIPC treatment via induction of HO-1. RIPC was applied to HO-1-luc transgenic mice and HO-1 promoter activity and mRNA expression in skin and several other organs were determined in real-time. In parallel, RIPC was applied directly or 24h prior to excisional wounding in mice to investigate the early and late protective effects of RIPC on cutaneous wound repair, respectively. HO-1 promoter activity was significantly induced on the dorsal side and locally in the kidneys following RIPC treatment. Next, we investigated the origin of this RIPC-induced HO-1 promoter activity and demonstrated increased mRNA in the ligated muscle, heart and kidneys, but not in the skin. RIPC did not change HO-1 mRNA and protein levels in the wound 7 days after cutaneous injury. Both early and late RIPC did not accelerate wound closure nor affect collagen deposition. RIPC induces HO-1 expression in several organs, but not the skin, and did not improve excisional wound repair, suggesting that the skin is insensitive to RIPC-mediated protection

Concepts sur l'orthodontie du futur : spéculations ou illusions ?

Grâce à la modélisation informatique, il sera possible dans le futur, pour le complexe dento-facial, d'évaluer les protocoles thérapeutiques en un système biologique. Les processus du développement des dents, de la tête et de la face pourront également être analysés de cette manière, tout comme les facteurs environnementaux qui les modifient. Il est certain que ce qui est déjà employé dans d'autres systèmes biologiques s'appliquera également tôt ou tard au système dento-facial et, de ce fait, à l'orthodontie. Avant d'y parvenir, nous devrons rassembler un grand nombre de données par des études réductionnistes

De invloed van bisfosfonaten op een orthodontische behandeling

Bisphosphonates are used in the treatment of various diseases which are associated with a disturbance of the balance between bone apposition and degradation. The most important complication of bisphosphonate use is osteonecrosis of the jaw. Certain components of an orthodontic treatment plan, such as the extraction of 1 or more teeth, are important risk factors in developing this complication. In addition to the desired effects on the bone metabolism, bisphosphonates may delay tooth eruption and inhibit or block orthodontic tooth movement. Nevertheless, case studies suggest that orthodontic treatment is possible despite the use of bisphosphonates. However, it is recommended to avoid orthodontic treatment unless this is strictly indicated.status: publishe

[Developments in fixed orthodontic appliances]

The Edgewise system and the Begg technique were until the early 1970's two of the most familiar and well-known fixed appliance techniques in orthodontics. During the following years they both underwent some slight adaptations that were generally based on more straightforward biomechanics. These changes have led to what in recent years is called the 'Straight Wire technique'. The latter claims to be the treatment option of choice based on preadjusted appliances and preformed arch wires. Besides biomechanics, treatment tools also concentrated on esthetics. It resulted in the development of smaller brackets as well as tooth coloured ones made from polycarbonates or ceramics. Finally lingual orthodontics starts to play a more important role in the orthodontic treatment options for the new millennium.status: publishe

In vitro peel/shear bond strength evaluation of orthodontic bracket base design

OBJECTIVES: The adhesive capacity of 17 different bracket types was evaluated in an in vitro peel/shear test. METHODS: Silane-treated metal bars were used as substrates with all bonding being performed using the orthodontic adhesive Concise. The effect of aluminium oxide air abrasion on the bonding performance of recycled metal bracket bases was evaluated. Morphological examination of the bracket bases was carried out under scanning electron microscopy. Statistics analysis included one-way ANOVA with Tukey's Studentized Range Test, two-way ANOVA and Weibull analysis. RESULTS: Mean peel/shear bond strength values range from 13.9 MPa for Allure Accu Arch, a ceramic bracket type, to 1.6 MPa for the plastic bracket CeramaFlex Advant Edge. Allure Accu Arch performed the best of all the ceramic brackets. However, bracket wing fracture was observed. The metal brackets Mini masters and Omni Arch showed no significant difference in bond strength compared with the ceramic bracket Allure Accu Arch (P < 0.01). CONCLUSION: The type of the bracket base determines its adhesive capacity. Sandblasting the base of recycled metal brackets had no uniform effect.status: publishe

Temporomandibular joint arthritis in juvenile idiopathic arthritis: Prevalence, clinical and radiological signs, and relation to dentofacial morphology

OBJECTIVE: To perform a prospective, comprehensive, clinical, and radiological evaluation of temporomandibular joint (TMJ) involvement and its influence on craniofacial growth, in a cohort of patients with juvenile idiopathic arthritis (JIA), representing all JIA subtypes. METHODS: Clinical rheumatologic and orthodontic evaluations were performed in 100 patients with JIA [12 systemic arthritis, 24 rheumatoid factor (RF)-negative polyarthritis, 1 RF-positive polyarthritis, 39 oligoarthritis, 22 enthesitis-related arthritis, 2 psoriatic arthritis]. An orthopantomogram and lateral cephalogram were performed in 46 patients. The prevalence of TMJ arthritis was studied in relation to JIA subtype and disease characteristics; cephalometric measurements were compared to those from age- and sex-matched healthy controls. RESULTS: Whereas 55% of patients with JIA had at least one symptom/sign of TMJ arthritis, 78% of the radiographed group exhibited condylar lesions. The presence of condylar damage was not related to clinical orthodontic findings or to JIA subtype, disease activity, severity, or duration. Patients with JIA exhibited larger mandibular plane and A-nasion-B angles, larger total anterior facial height, smaller interincisal and sella-nasion-B angles, and shorter mandibular ramus lengths than their age- and sex-matched controls. Craniofacial alterations were clearly related to the presence of condylar damage, even when present at a minimal degree. CONCLUSION: Our data show that TMJ condylar damage occurs very frequently in JIA, and irrespective of JIA subtype; condylar lesions can present early, progress insidiously, and -- even at a minimal degree -- can severely alter the craniofacial profile. We propose that the followup of patients with JIA should include early and regular evaluation by an orthodontist, supplemented with radiographic TMJ imaging.status: publishe

[Genetics and tooth eruption disorders: a future exploration]

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Cranio-maxillofacial, orthodontic and dental treatment in three patients with Apert syndrome

BACKGROUND: Apert syndrome is a severe developmental malformation, clinically characterised by craniosynostosis, midface hypoplasia, a cone-shaped calvarium, ocular manifestations, typical dental findings and syndactyly of the hands and feet. Early craniosynostosis of the coronal suture, the cranial base and agenesis of the sagittal suture are prodromal characteristics for the typical craniofacial appearance in patients with Apert syndrome. CASE REPORTS: The aim of this report was to describe the maxillofacial and orthodontic management of three patients with Apert syndrome who attended the Craniofacial, Maxillofacial and Orthodontic clinics of the University Hospitals of the KU Leuven (Belgium). The typical clinical features, the general orthognathic treatment approach as well as individual approaches of three patients with Apert syndrome are being highlighted. FOLLOW-UP: The three patients with Apert syndrome have been followed up very closely by all involved specialised departments as well as by multidisciplinary teams from birth. CONCLUSION: This report demonstrated that a combined orthodontic and orthognathic surgical treatment plan could significantly improve the occlusal function as well as the facial and occlusal aesthetics in patients with Apert syndrome.status: publishe