4 research outputs found
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICāHF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- AboāAuda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- AriasāMendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- BieringāSĆørensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Bƶhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
- Constance Christian
- Contreras Johanna
- Corbalan Ramon
- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- CostaāVitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- CrespoāLeiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlstrƶm Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
- Dib Nabil
- Diez Mirta
- Dimov Bojidar
- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
- Donnelly Patrick
- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen HansāDirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
- Elvan Arif
- Esperon Guillermo Antonio Llamas
- Ezekowitz Justin
- Ezhov Marat
- Fang James
- Fang James C.
- Farris Neil
- Feitell Scott
- Felker G. Michael
- Fernandez Alberto
- Fernando Ronald
- Ferraz Almir
- Figal Domingo Andres Pascual
- Filho Otavio Coelho
- Filho Pedro Pimentel
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- Forster Tamas
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- Fourie Nyda
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- Frankenstein Lutz
- Freire Ramon Bover
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- Frigerio Maria
- Friz Hernan Emilio Francisco Polo
- Fu Xin
- Fucili Alessandro
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- Fujii Kenshi
- Fujii Shigeru
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- Gabriel George
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- Goudev Assen
- Goudev Assen R.
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- Howlett Jonathan G.
- Huang He
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- Hullin Roger
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- Usui Makoto
- Utsu Noriaki
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- Van Zyl Louis
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- Vandekerckhove Hans
- Vanhecke Thomas
- Varin Claire
- Vasallo Javier
- Vasilev Ivaylo
- Vasilyeva Larysa
- Vaz Garth
- Vazquez Eduardo Salcido
- Vega Mario
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- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo NuƱez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu OlgaāCristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- WozakowskaāKaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICāHF) trial. Here we describe the baseline characteristics of participants in GALACTICāHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)āā„āII, EF ā¤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticāguided dosing: 25, 37.5 or 50āmg bid). 8256 patients [male (79%), nonāwhite (22%), mean age 65āyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTāproBNP 1971āpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICāHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureā<ā100āmmHg (n = 1127), estimated glomerular filtration rate <ā30āmL/min/1.73 m2 (n = 528), and treated with sacubitrilāvalsartan at baseline (n = 1594).
Conclusions:
GALACTICāHF enrolled a wellātreated, highārisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
A potential genomic biomarker for the detection of polycyclic aromatic hydrocarbon pollutants: multidrug resistance gene 49 in Drosophila melanogaster.
- Author
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/07/2007
- Field of study
International audiencePolycyclic aromatic hydrocarbons (PAHs) are a major source of air, water, and soil pollution. The multidrug resistance (mdr)/permeability glycoprotein (P-gp) complex is implicated in the multidrug resistance pattern developed against various drugs and xenobiotics, including polycyclic aromatic hydrocarbons. In order to develop a genomic biomarker, we investigated the response of the mdr49 gene (mdr49) of Drosophila melanogaster to PAHs. Structural analysis of mdr49-PA, which is the putative protein expressed from Drosophila mdr49 gene, demonstrated that this transmembrane protein indeed belongs to the adenosine triphosphate-binding cassette transporter superfamily. Polymerase chain reaction (PCR) and real-time PCR analysis revealed that the mdr49 gene is expressed continuously at all the stages of fly development, including embryos, pupae, larvae, and adults, as well as in embryonic Drosophila S12 cells. In the adult fly, the mdr49 gene was expressed in all the analyzed segments (head, thorax, and abdomen) and organs (olfactory and sexual organs). The quantification of mdr49 transcripts by real-time PCR in adult flies exposed to benzo[a]pyrene over time or in presence of increasing concentrations of this pollutant showed a clear dose-dependent response. Similarly, mdr49 gene expression increased after adult flies were exposed to structurally varied PAHs. The detection of tested PAHs by Drosophila P-gp efflux pump was checked by flow cytometry
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres IƱiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
- Ciro Indolfi
- Claire Varin
- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
- Claudio Bilato
- Claudio Cavallini
- Claudio Rodolfo Majul
- Cleland J. G. F.
- Coenraad van der Zwaan
- Constantin Militaru
- Corbalan R.
- Craig Barr
- Craig Hametz
- Crespo-Leiro M. G.
- Cristian Gheorghe Podoleanu
- Cristiano Pederneiras Jaeger
- Cristina Danila
- Csaba Salamon
- Dahlstrom U.
- Dalia Jarasuniene
- Dallas Price
- Dalton McLean
- Daniel Aradi
- Daniel Beug
- Daniel Fisher
- Daniel Gaudet
- Daniel Lenihan
- Daniel Lighezan
- Daniel Pauly
- Daniel Savard
- Daniel Vogel
- Daniela Garcia Brasca
- Daniela Pini
- Daniela Vinanska
- Dariusz Korczyk
- David Chang
- David F Kong
- David Henderson
- David Lanfear
- David Murray
- David Rawitscher
- David Schultz
- David Stepek
- David Whellan
- Debashis Roy
- Deddo Moertl
- Denis-Carl Phaneuf
- Dennis Rupka
- Deovrat Singh
- Devesh Patel
- Diana Bonderman
- Diaz R.
- Diego Alejandro Besada
- Diego Felipe Martinez
- Dimitrios Tziakas
- Dinesh Gupta
- Dipti Itchhaporia
- Dirk Boswijk
- Dirk Lok
- Dirk Schellings
- Dmitriy Belenkiy
- Dmitry Dronov
- Dmytro Reshotko
- Domenico Bonaduce
- Domingo Andres Pascual Figal
- Dongye Li
- Donna Mancini
- Dora Ines Molina de Salazar
- Douglas Brinkley
- Douglas Martel
- Douglas Sawyer
- Dragos Vinereanu
- Driek Beelen
- Dulce Brito
- Dumitru Zdrenghea
- Echeverria L. E.
- Edmundo Alfredo Bayram Llamas
- Edo Kaluski
- Eduardo Perna
- Eduardo Salcido Vazquez
- Edward Geltman
- Edward Portnay
- Egon Lenner
- Eileen O'Meara
- Einas Elmahi
- Eiran Gorodeski
- Elena Cowan
- Elena Kosmacheva
- Elena Kulibaba
- Elena Shutemova
- Ellis Lader
- Elvin Kedhi
- Erberto Carluccio
- Eric Decoulx
- Eric Klug
- Erik Hajko
- Ersel Onrat
- Ertugrul Okuyan
- Erwan Donal
- Eugene Chung
- Eugene Joseph Bauerlein
- Euler Roberto Fernandes Manenti
- Eva Goncalvesova
- Eva Peterfai
- Ewa Kalecinska-Krystkiewicz
- Ewa Straburzynska-Migaj
- Fabiana Rollini
- Fabio Silveira
- Fady I Malik
- Faiez Zannad
- Faisal Wahid
- Fang J. C.
- Farid Jadbabaie
- Felice Achilli
- Felix Ramires
- Feng Liu
- Ferenc Lakatos
- Fernando Bacal
- Fernando Boccalandro
- Fernando Colombo Berra
- Fernando Manzur Jattin
- Fernando Soto Loureiro
- Fernando Tomas Lanas Zanetti
- Filipa Almeida
- Filippatos G.
- Flavio Brito
- Flavio Eduardo Giorgeto
- Florence Rothenberg
- Florin Mitu
- Fonseca C.
- Fragkiskos Parthenakis
- Francesco Franchi
- Francisco Gonzalez Vilchez
- Francois Roubille
- Frank McGrew
- Frank Smart
- Frank Willems
- Franklin Handel
- FranƧois Picard
- Freny Mody
- Friedrich Fruhwald
- Fumi Yamamoto
- G Michael Felker
- Gabriel Arturo Ramos Lopez
- Gabriela Stanciulescu
- Gabriele Jakl-Kotauschek
- Gaetano Maria De Ferrari
- Garth Vaz
- Gary Yeoman
- Gaurav Aggarwala
- Georg Noll
- George Gabriel
- George Kochiadakis
- George Marzouka
- George Sokos
- Georgi Todorov
- Georgiy Dzyak
- Georgy Arbolishvili
- Gerardo Zapata
- Gerardus Linssen
- Gerasimos Filippatos
- Gerhard Poelzl
- Geza Lupkovics
- Giancarlo Piovaccari
- Gianfranco Sinagra
- Gianpiero Perna
- Gilmar Reis
- Gintare Sakalyte
- Giovanni Geronilla
- Giovanni Quinto Villani
- Giuseppe Ambrosio
- Giuseppe Musumeci
- Glenn Hamroff
- Goncalvesova E.
- Gordon Moe
- Gordon Reeves
- Goudev A. R.
- Gregorio Sanchez Vallejo
- Gregory Sampognaro
- Gregory Szto
- Gregory Thomas
- Grigorios Giamouzis
- Grzegorz Kania
- Grzegorz Skonieczny
- Guillaume De Geeter
- Guillaume Jondeau
- Guillermo Antonio Llamas Esperon
- Guoqin Chen
- Gurinder Grewal
- Gurusher Panjrath
- Gustavo Francisco Mendez Machado
- Guy Proulx
- Gyula Szasz
- Hakima Bourhaial
- Hal Skopicki
- Hamish Hart
- Hanbin Cui
- Hans Vandekerckhove
- Hans-Dirk Duengen
- Haralambos Karvounis
- Harinder Gogia
- Harukazu Iseki
- Hassan Ibrahim
- He Huang
- Heinz Drexel
- Hendrik Zimmet
- Henning Ebelt
- Henricus Van Kesteren
- Henrik Wiggers
- Henry Dargie
- Henry Ooi
- Hernan Emilio Francisco Polo Friz
- Hideki Ueno
- Hideo Izawa
- Hideo Kawakami
- Hideyuki Tsuboi
- Hiroaki Kitaoka
- Hiroaki Kiyokawa
- Hiroki Uehara
- Hiroshi Asano
- Hiroshi Domae
- Hiroshi Ito
- Hiroshi Meno
- Hiroshi Sugino
- Hiroshi Takaishi
- Hiroyuki Kawata
- Hisao Hara
- Hisashi Kai
- Holger Killat
- Honarpour N.
- Horacio Alberto Avaca
- Howlett J. G.
- Hugo Luquez
- Huifang Tang
- Ian Buysschaert
- Ibrahim Haldun Muderrisoglu
- Ichiro Michishita
- Ignacio Mackinnon
- Igor Kraiz
- Igor Motylev
- Igor Vakaliuk
- Iman Chouchane
- Imre Szakal
- Inder Anand
- Inder Singh
- Ioannis Barbetseas
- Ioannis Mantas
- Ioannis Styliadis
- Ira Dauber
- Irina Osipova
- Irina Semenova
- Iurii Rudyk
- Ivan Goncharov
- Ivan Majercak
- Ivana Kellnerova
- Ivaylo Vasilev
- Ivo Petrov
- Ivo Podpera
- J Dedrick Jordan
- J Russell Strader
- Jacob Eifer Moller
- Jacob Van Eck
- Jadwiga Nessler
- Jagadeesh Ganji
- James Elliott
- James Fang
- James L Januzzi
- James Rider
- James Watts
- Jan Belohlavek
- Jan Stevlik
- Jana Lukacova
- Janka Skrobakova
- Janos Tomcsanyi
- Janusz Spyra
- Jaroslaw Drozdz
- Jaroslaw Trebacz
- Jason C Legg
- Jason Glover
- Jasper Trevelyan
- Javed Butler
- Javier Segovia Cubero
- Javier Vasallo
- Jean Etienne Ricci
- Jean-Louis Georges
- Jean-Marie Lefebvre
- Jean-Michel Tartiere
- Jean-Noel Trochu
- Jean-Pierre Gueffet
- Jeffrey Martindale
- Jelena Celutkiene
- Jenica N Upshaw
- Jennifer Cook
- Jens Taggeselle
- Jeremy Cox
- Jeroen Schaap
- Jerzy Kopaczewski
- Jianjun Li
- Jindrich Spinar
- Jing Li
- Jing Yan
- Jinguo Zhang
- Jiri Krupicka
- Jiyan Chen
- Joao Carlos Braga
- Joaquin Martinez-Arraras
- Johanna Contreras
- Johannes Remmen
- John Amerena
- John Andrew Morrow
- John Atherton
- John Beltrame
- John Boehmer
- John Cleland
- John Collins
- John Corbelli
- John French
- John Groarke
- John Harris
- John Heitner
- John J V McMurray
- John Kao
- John Mignone
- John Murray
- John Parissis
- John van Hal
- Jolita Badariene
- Jonathan Howlett
- Jooyoung Shin
- Jorge Cheirif
- Jorge Leonardo Cobos Segarra
- Jorge Roberto Aiub
- Jorgen Jeppesen
- Jose Alfredo Pagola Carrasco
- Jose Augusto Ribas Fortes
- Jose Cardona
- Jose Francisco Saraiva
- Jose Luis Accini Mendoza
- Jose Luis Arenas Leon
- Jose Luis Lambert Rodriguez
- Jose Maria Arizon Del Prado
- Jose Ramon Gonzalez Juanatey
- Joseph Massaro
- Joseph Radojevic
- Joseph Rahman
- Joshua Asubiaro
- Jozef Gonsorcik
- Juan Francisco Delgado Jimenez
- Juan Jose Gomez Doblas
- Juan Londono
- Juan Luis Bonilla Palomas
- Julian Alonso Coronel Arroyo
- Julian Javier
- Juliano Cardoso
- Julio Eduardo NuƱez Villota
- Julio IbaƱez
- Julio Tallet
- Jun Tanabe
- Junji Kanda
- Justin Ezekowitz
- Justin Taylor
- Kabir Yousuf
- Kahraman Cosansu
- Kalman Toth
- Kamil Zeman
- Kaoru Okishige
- Karel Peterka
- Karel Sochor
- Karen P Alexander
- Karen Sliwa
- Karl Dujardin
- Karl Heilman
- Katalin Bezzegh
- Katerina Naka
- Katsunori Kawamitsu
- Kazuhisa Mitsuo
- Keiji Ujino
- Keijiro Saku
- Keisuke Kida
- Keith Aaronson
- Keith Friedman
- Kenji Ando
- Kenji Onoue
- Kenneth Wong
- Kenshi Fujii
- Kentaro Nakamura
- Keyur Shah
- Kimberly Cruz
- Kimiaki Nagase
- Kirkwood Adams
- Klemens Ablasser
- Kodangudi Ramanathan
- Koichi Node
- Koichiro Sugimura
- Konstantin Zrazhevskiy
- Konstantinos Tsioufis
- Kotaro Numaguchi
- Kouji Kajinami
- Krzysztof Cymerman
- Kumiko Nakayama
- Kunihiko Makino
- Kurt Boman
- Kurt Huber
- Kurtz C. E. GALACTIC-HF Investigators: John R Teerlink
- Ladislav Busak
- Lana Tsao
- Lanfear D. E.
- Larry Allen
- Lars Videbaek
- Larysa Mishchenko
- Larysa Vasilyeva
- Laszlo Mark
- Laszlo Nagy
- Laura Jordan Martinez
- Laurie Letarte
- Lawrence Galitz
- Lawrence J Lesko
- Legg J. C.
- Leighton Kearney
- Lenka Spinarova
- Leonard Pianko
- Leonardo Macias
- Leonardo Novaretto
- Leonid Pimenov
- Leonid Rudenko
- Leonid Voronkov
- Leopoldo Soares Piegas
- Lesley Burgess
- Lesya Rasputina
- Li J.
- Libor Nechvatal
- Lidia Ana Zytynski Moura
- Lidia Pawlowicz
- Lilia Luz Lobo Marquez
- Lilia Nigro Maia
- Lilia Schiavi
- Liliana Nicolosi
- Lily Zhang
- Lisa Mielniczuk
- Liudmyla Alieksieieva
- Lixin Jiang
- Llyod Stahl
- Lokesh Chandra
- Louis Van Zyl
- Luanda Grazette
- Lubomir Antalik
- Luc Pierard
- Lucie Sharpsten
- Lucyna Lenartowska
- Luis Almenar Bonet
- Luis Beck da Silva Neto
- Luis de la Fuente Galan
- Luis Eduardo Echeverria
- Luis Eduardo Echeverria
- Luis Horacio Atehortua Lopez
- Luis Martinez
- Luis Oliveira
- Luis Santos
- Lund M.
- Lutfu Bekar
- Lutz Frankenstein
- Macdonald P.
- Maciej Zabowka
- Madhusudhan Pamganamamula
- Magnus Peterson
- Mahazarin Ginwalla
- Makoto Nakahama
- Makoto Usui
- Malgorzata Konieczynska
- Malgorzata Lelonek
- Malik F. I.
- Mamoru Manita
- Manoel Canesin
- Manohara Senaratne
- Manuel Bouza
- Manuel Eduardo Rodriguez Venegas
- Manuel Martinez-Selles D Oliveira Soares
- Manuel Odin De Los Rios Ibarra
- Marat Ezhov
- Marc Simon
- Marcelo Alejandro Garrido
- Marcin Szczasny
- Marco Metra
- Marcos Amuchastegui
- Marcos Raul Litvak Bruno
- Marcus Mittag
- Marcus Sandri
- Marcus Stoddard
- Marcus Vinicius Simoes
- Mareev V.
- Marek Houra
- Marek Piatek
- Margarita Gertrudis Vejar Jalaf
- Maria Alexandra Arias Mendoza
- Maria Cristina Schnettler Cid
- Maria Dorobantu
- Maria Frigerio
- Maria Generosa Crespo Leiro
- Maria Helena Vidotti
- Maria Leonor Parody
- Maria Sanali Paiva
- Maria Sitnikova
- Maria Teresa Blasco Peiro
- Maria Tzekova
- Mariel Rivero
- Mariela Rasmussen
- Marilena Renata Spiridon
- Mario Vega
- Mario Villoch
- Mario Yanez Hidalgo
- Marisa Crespo Leiro
- Marisa Orgera
- Mariusz Kafara
- Mark Abelson
- Mark Ramos
- Mark Smith
- Mark Zucker
- Martin Berk
- Martin Huelsmann
- Martin LeWinter
- Marvin A Konstam
- Mary Lynch
- Masahiro Ishikawa
- Masahiro Suzuki
- Masaki Yoshikawa
- Masanori Asakura
- Masaru Yuge
- Masayoshi Ajioka
- Masayuki Doi
- Masuki Mori
- Mateusz Sidor
- Mathue Baker
- Matt Wilkett
- Matteo Di Biase
- Matthew Janik
- Matthew Wheeler
- Matthias Dupont
- Maurizio Volterrani
- Mayanna Lund
- McMurray J. J. V.
- Mehmet Birhan Yilmaz
- Mehmet Birhan Yilmaz
- Mehmet Duzenli
- Mehrdad Ariani
- Melchor Alpizar Salazar
- Melvin Martinez-Castrillon
- Mesut Demir
- Metra M.
- Michael Boehm
- Michael Bƶhm
- Michael Felker G.
- Michael Hartleib
- Michael Koren
- Michael Kwan
- Michael Magro
- Michael Miyamoto
- Michael Pham
- Michael Radin
- Michal Cepelak
- Michel Galinier
- Michel Ovize
- Michele Hamilton
- Michele Senni
- Miguel Alfredo Moncada Corredor
- Miguel Angel Hominal
- Miguel Urina Triana
- Mikhail Kotelnikov
- Mikhail Voevoda
- Milan Gupta
- Mio Ebato
- Mircea Ioachim Popescu
- Mirta Diez
- Mitsuhiro Shimomura
- Mitsuru Tsujimoto
- Mitsutaka Yamamoto
- Mohammad Abuannadi
- Mohan Babapulle
- Momomura S.
- Monica Lopez Pareja
- Mori Krantz
- Mukesh Sharma
- Munir Janmohamed
- Muriel Salvat
- Mustafa Tuncer
- Mustafa Vural
- Mykola Rishko
- Mykola Stanislavchuk
- Nabil Dib
- Nadia Giannetti
- Naeem Tahirkheli
- Nampalli Vijay
- Nancy Sweitzer
- Nandini Nair
- Nandkishore Ranadive
- Naoki Sato
- Naoki Watanabe
- Narimon Honarpour
- Naseem Jaffrani
- Nasir Sulemanjee
- Natale Daniele Brunetti
- Nataliya Shilkina
- Nathan Mewton
- Natsuki Takahashi
- Navid Kazemi
- Navin Rajagopalan
- Neil Farris
- Neil Lewis
- Nicholas Kondo
- Nicole Lohr
- Niels Gadsboll
- Niels Menck
- Nikolay Tarasov
- Nishant Shah
- Nobuhide Miyamoto
- Nobuyuki Komiyama
- Noemi Nyolczas
- Nolan Mayer
- Norberto Duda
- Noriaki Takama
- Noriaki Utsu
- Norman Lepor
- Nqoba Tsabedze
- Nyda Fourie
- O'Meara E.
- Okan Onur Turgut
- Ole Nyvad
- Oleg Solovev
- Oleksandr Karpenko
- Oleksandr Parkhomenko
- Oleksandr Prokhorov
- Oleksii Korzh
- Oleksii Kulynych
- Olga Barbarash
- Olga Bolshakova
- Olga-Cristina Voicu
- Omar Almousalli
- Ondrej Jerabek
- Oscar Alberto Gomez Vilamajo
- Oscar Alejandro Salomone
- Oscar Romano Montana
- Oswaldo Greco
- Oswaldo Sandoval
- Otavio Coelho Filho
- Ozer Badak
- Paramdeep Baweja
- Parkhomenko A.
- Pascal De Groote
- Pascalle van Huysduynen-Monraats
- Pastor Olaya Rojas
- Patric Karlstrom
- Patrick Davey
- Patrick Donnelly
- Patrizio Lancellotti
- Paul Kalra
- Paulo Ernesto Leaes
- Paulo Roberto Ferreira Rossi
- Pavel Koleckar
- Pawel Balsam
- Pawel Miekus
- Pedro Gabriel Melo de Barros E Silva
- Pedro Monteiro
- Pedro Morais Sarmento
- Pedro Pimentel Filho
- Peili Bu
- Peter Andreka
- Peter Carson
- Peter Fulop
- Peter Kaiser-Nielsen
- Peter Macdonald
- Peter Rahko
- Peter Siostrzonek
- Peter Wodlin
- Petr Tyl
- Philip Haines
- Philip Keeling
- Philippe Berdague
- Philippe Meyer
- Piergiuseppe Agostoni
- Piers Clifford
- Ping Yang
- Piotr Berkowski
- Piotr Jankowski
- Piotr Ponikowski
- Ponikowski P.
- Pradeep Singh
- Pranas Serpytis
- Pratik Desai
- Priya Pillutla
- Qinghua Han
- Radim Kryza
- Rafael Diaz
- Rafael DĆaz
- Rafael Luiz Rech
- Rafik Abadier
- Raja Chehayeb
- Rajat Barua
- Rajendra H Metha
- Rajendran Moodley
- Rajesh Sharma
- Rakesh Bhargava
- Ralf Westenfeld
- Rami Alharethi
- Ramires F. J. A.
- Ramon Bover Freire
- Ramon Corbalan
- Ramon Corbalan Herreros
- Randall Starling
- Raul Reyes Araiza
- Raveen Arora
- Ravi Bhagwat
- Renato Chaves
- Renato Lopes
- Ricardo Alfonso Leon de la Fuente
- Ricardo Garcia Gonzalez
- Richard Fremont
- Richard Gilmore
- Richard Isnard
- Richard Katz
- Rimvydas Slapikas
- Rita Kazinczy
- Robert Buynak
- Robert Gianfagna
- Robert Kowalski
- Robert McKelvie
- Robert Mohapatra
- Robert Schnitzler
- Robert Stewart
- Robert W Harrison
- Robert W McGarrah
- Roberta Bogaev
- Roberta Rossini
- Roberto Colque
- Robin Mathews
- Robin Weir
- Rodolfo Andres Ahuad Guerrero
- Rodrigo Botero Lopez
- Rodrigo da Silva
- Rodrigo Julio Cerci
- Roger Hullin
- Roman Margoczy
- Roman Myasnikov
- Roman Pfister
- Roman Stets
- Ronald Bourgeois
- Ronald Fernando
- Ronald Zolty
- Rosario Santa Fe
- Rostislav Polasek
- Ruben Omar Garcia Duran
- Rudolf Smik
- Rudolf Spacek
- Rudolf Uhliar
- Russell Scott
- Ruud van de Wal
- Ryszard Sciborski
- RĆ©mi Sabatier
- Saad Ahmad
- Sabine Genth-Zotz
- Salvador Leon Gonzalez
- Salvador Rassi
- Sana M Al-Khatib
- Sandra Chaparro
- Sanem Nalbantgil
- Sanjay Malhotra
- Sanjeev Saxena
- Sara Llerena
- Sara Soares Goncalves
- Satoru Sakagami
- Scott D Solomon
- Scott Feitell
- Scott Franczek
- Scott McKenzie
- Sebastian Velez Pelaez
- Seigo Masuda
- Seiichiro Gohara
- Sergey Boytsov
- Sergey Tereschenko
- Sergio Leonardi
- Sergio Potthoff
- Serpytis P.
- Shafiq Mamdani
- Shahid Mahmood
- Shamaila Aslam
- Sharpsten L.
- Shaumik Adhya
- Shawn Robinson
- Shelley Zieroth
- Sherryn Roth
- Shigeru Fujii
- Shigeru Fukuzawa
- Shin-Ichi Momomura
- Shinichiro Miura
- Shitoshi Hiroi
- Shogo Oishi
- Shouyan Zhang
- Shreyansh Shah
- Shuaib Abdullah
- Shuichi Taguchi
- Shumei Ma
- Shunsuke Tatebe
- Shuntaro Kagiyama
- Siddique Abbasi
- Silvia Lopez Fernandez
- Sliwa K.
- Snezhanka Tisheva-Gospodinova
- Solomon S. D.
- Sonia Mirabet Perez
- Sonia Sassone
- Soren Vraa
- Sorin Stamate
- Sotirios Patsilinakos
- Sourin Banerji
- Spinar J.
- Stavros Drakos
- Stefan Berglund
- Stefan Stƶrk
- Stephan von Haehling
- Stephanie Olsen
- Stephen Gottlieb
- Stephen Halpern
- Stephen Rennyson
- Steven Forman
- Steven Hearne
- Steven Krueger
- Steven Lupovitch
- Steven Shayani
- Sunder Rao
- Sunil Pauwaa
- Susan Joseph
- Suter T. M.
- Svetlana Dovgolis
- Svetlana Villevalde
- Syed Hasni
- Takaaki Isshiki
- Takahiro Okumura
- Takahiro Tanaka
- Takashi Matsumoto
- Takashi Takenaka
- Takayuki Hidaka
- Takayuki Inomata
- Takeshi Serikawa
- Takeshi Yoshida
- Tamas Forster
- Tariq Haddad
- Tatiana Duarte
- Tayfun Sahin
- Teerlink J. R.
- Terence Hart
- Terrence O'Brien
- Tetsuo Sakai
- Tetsuro Miyazaki
- Tetsuya Amano
- Thao Huynh
- Theodore Frank
- Theodore Takata
- Thibaud Damy
- Thierry Laperche
- Thomas Ashcom
- Thomas Duythuc To
- Thomas Horacek
- Thomas Hucko
- Thomas J Povsic
- Thomas Suter
- Thomas Vanhecke
- Tianfa Li
- Tienush Rassaf
- Timothy Doyle
- Tina Sichrovsky
- Tiziano Moccetti
- Tjeerd Rƶmer
- Tokushi Koga
- Tom Smilde
- Tomas Brabec
- Tomasz Blicharski
- Tomasz Borkowski
- Tomcsanyi J.
- Tomohiro Kawasaki
- Tomohiro Ogawa
- Tomohiro Sakamoto
- Tomomi Koizumi
- Tonny Nielsen
- Tor Biering-SĆørensen
- Toru Kubota
- Toshiaki Kadokami
- Toshio Kasai
- Toshiro Terasaki
- Ulf Dahlstrom
- Umit Guray
- Uwe Zeymer
- Valentina Mincheva
- Valerio Zaca
- Valery Popov
- Vandekerckhove H.
- Varin C.
- Vasilios Papademetriou
- Vedampattu Ganeshram
- Venkatesh Nadar
- Vernon Hunter
- Veselin Mitrovic
- Viacheslav Mareev
- Vicente Eduardo Climent Paya
- Victor Aboyans
- Victor Alfonso Jimenez Diaz
- Victor Areli Saavedra Gajardo
- Viktor Kostenko
- Vilma Machova
- Vinay Malhotra
- Vinay Thohan
- Vinereanu D.
- Viorel Florea
- Vira Tseluyko
- Vittorio Giudici
- Viviane Nguyen
- Vladimir Cech
- Vladimir Cotarlan
- Vladimir Nosov
- Vladimir Rafalskiy
- Vladimir Salukhov
- Vladislav Mitrokhin
- Voors A. A.
- Vyacheslav Mareev
- Vyacheslav Ryabov
- W Schuyler Jones
- Wael AboAuda
- Wakaya Fujiwara
- Walter Abhayaratna
- Walter Droogne
- Walter Hermans
- Wataru Shimizu
- Wayne Gray
- Weiheng Wu
- Weimar Kunz Barroso de Souza
- Weimin Li
- Wentang Niu
- Wilder CastaƱo Osorio
- William Anderson
- William Herzog
- William Nelson
- William Randall
- Wissam Khalife
- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
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- Araki Yasuhiro
- Arasaki Kohei
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- Araya Jun
- Arden Catherine
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- Arguelles Sandro
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- Cheng Xiaodong
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- Cheng Yiyun
- Cheng Zhiyong
- Cheong Heesun
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- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
- Ying Meidan
- Ying Zheng
- Yip Calvin K
- Yiu Stephanie Pei Tung
- Yoo Young H
- Yoshida Kiyotsugu
- Yoshii Saori R
- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field