Finite reduction and Morse index estimates for mechanical systems

A simple version of exact finite dimensional reduction for the variational setting of mechanical systems is presented. It is worked out by means of a thorough global version of the implicit function theorem for monotone operators. Moreover, the Hessian of the reduced function preserves all the relevant information of the original one, by Schur's complement, which spontaneously appears in this context. Finally, the results are straightforwardly extended to the case of a Dirichlet problem on a bounded domain.Comment: 13 pages; v2: minor changes, to appear in Nonlinear Differential Equations and Application

Therapeutic Use of Self and Fieldwork Experience: An Exploration of the Art and Science of Occupational Therapy

The clinical practice of occupational therapy has been described as a blend of both art and science. For occupational therapy students, Level II fieldwork experiences offer early opportunities to refine both client-centered attitudes and scientific aptitude in relationship-based caregiving. In this retrospective study, researchers examined the ability to predict final Fieldwork Performance Evaluation scores from the following non-cognitive (i.e., art) and cognitive (i.e., science) variables: ranked student responses to the Self-Assessment of Modes Questionnaire (v.II); undergraduate grade point average (GPA; cumulative and science), and Graduate Record Examination (GRE) scores (quantitative, verbal, and analytic). Using a series of simple linear regressions, researchers analyzed data from sixty-nine master’s-level occupational therapy students. For the first Level II fieldwork experience, empathizing and empathizing-revised modes appeared to be a significant predictor with moderate, positive correlation coefficients (p=.008, r=.329; p=.01, r=.296, respectively). For the second Level II fieldwork experience, collaborating and instructing modes appeared to be significant predictors (p=.036, r= -.255; p=.037, r=.254 respectively). GPA and GRE scores were not predictive of fieldwork success. The degree to which art and science shape expectations for relationship-based client interactions during fieldwork experiences requires further investigation. However, calling attention to occupational therapy students’ preferred communication modes highlight how client interactions may be shaped to fit the students’ natural tendencies rather than the needs of the client

The M3A multi-sensor buoy network of the Mediterranean Sea

International audienceA network of three multi-sensor timeseries stations able to deliver real time physical and biochemical observations of the upper thermocline has been developed for the needs of the Mediterranean Forecasting System during the MFSTEP project. They follow the experience of the prototype M3A system that was developed during the MFSPP project and has been tested during a pilot pre-operational period of 22 months (2000?2001). The systems integrate sensors for physical (temperature, salinity, turbidity, current speed and direction) as well as optical and chemical observations (dissolved oxygen, chlorophyll-a, PAR, nitrate). The south Aegean system (E1-M3A) follows a modular design using independent mooring lines and collects biochemical data in the upper 100 m and physical data in the upper 500 m of the water column. The south Adriatic buoy system (E2-M3A) uses similar instrumentation but on a single mooring line and also tests a new method of pumping water samples from relatively deep layers, performing analysis in the protected ''dry'' environment of the buoy interior. The Ligurian Sea system (W1-M3A) is an ideal platform for air-sea interaction processes since it hosts a large number of meteorological sensors while its ocean instrumentation, with real time transmission capabilities, is confined in the upper 50 m layer. Despite their different architecture, the three systems have common sampling strategy, quality control and data management procedures. The network operates in the Mediterranean Sea since autumn 2004 collecting timeseries data for calibration and validation of the forecasting system as well for process studies of regional dynamics

The Mediterranean Moored Multi-sensor Array (M3A): system development and initial results

International audienceOperational forecasting of ocean circulation and marine ecosystem fluctuations requires multi-parametric real-time measurements of physical and biochemical properties. The architecture of a system that is able to provide such measurements from the upper-thermocline layers of the Mediterranean Sea is described here. The system was developed for the needs of the Mediterranean Forecasting System and incorporates state-of-the-art sensors for optical and chemical measurements in the upper 100 m and physical measurements down to 500 m. Independent moorings that communicate via hydro-acoustic modems are hosting the sensors. The satellite data transfer and the large autonomy allow for the operation of the system in any open-ocean site. The system has been in pre-operational use in the Cretan Sea since January 2000. The results of this pilot phase indicate that multi-parametric real-time observations with the M3A system are feasible, if a consistent maintenance and re-calibration program is followed. The main limitations of the present configuration of M3A are related: (a) to bio-fouling that primarily affects the turbidity and secondarily affects the other optical sensors, and (b) to the limited throughput of the currently used satellite communication system. Key words. Atmospheric composition and structure (instruments and techniques.) Oceanography: general (ocean prediction) Oceanography: physical (upper ocean process

Resting-state functional connectivity in deaf and hearing individuals and its link to executive processing

Sensory experience shapes brain structure and function, and it is likely to influence the organisation of functional networks of the brain, including those involved in cognitive processing. Here we investigated the influence of early deafness on the organisation of resting-state networks of the brain and its relation to executive processing. We compared resting-state connectivity between deaf and hearing individuals across 18 functional networks and 400 ROIs. Our results showed significant group differences in connectivity between seeds of the auditory network and most large-scale networks of the brain, in particular the somatomotor and salience/ventral attention networks. When we investigated group differences in resting-state fMRI and their link to behavioural performance in executive function tasks (working memory, inhibition and switching), differences between groups were found in the connectivity of association networks of the brain, such as the salience/ventral attention and default-mode networks. These findings indicate that sensory experience influences not only the organisation of sensory networks, but that it also has a measurable impact on the organisation of association networks supporting cognitive processing. Overall, our findings suggest that different developmental pathways and functional organisation can support executive processing in the adult brain

Photochemically Etched Construction Technology Developed for Digital Xenon Feed Systems

Electric propulsion systems are quickly emerging as attractive options for primary propulsion in low Earth orbit, in geosynchronous orbit, and on interplanetary spacecraft. The driving force behind the acceptance of these systems is the substantial reduction in the propellant mass that can be realized. Unfortunately, system designers are often forced to utilize components designed for chemical propellants in their electric systems. Although functionally acceptable, these relatively large, heavy components are designed for the higher pressures and mass flow rates required by chemical systems. To fully realize the benefits of electric propulsion, researchers must develop components that are optimized for the low flow rates, critical leakage needs, low pressures, and limited budgets of these emerging systems

Relations between dynamo-region geometry and the magnetic behavior of stars and planets

The geo and solar magnetic fields have long been thought to be very different objects both in terms of spatial structure and temporal behavior. The recently discovered field structure of a fully convective star is more reminiscent of planetary magnetic fields than the Sun's magnetic field (Donati J.-F. et al., Science, 311 (2006) 633), despite the fact that the physical and chemical properties of these objects clearly differ. This observation suggests that a simple controlling parameter could be responsible for these different behaviors. We report here the results of three-dimensional simulations which show that varying the aspect ratio of the active dynamo region can yield sharp transition from Earth-like steady dynamos to Sun-like dynamo waves

Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection

<p>Abstract</p> <p>Background</p> <p>Phosphorothioated oligonucleotides (PS-ONs) have a sequence-independent, broad spectrum antiviral activity as amphipathic polymers (APs) and exhibit potent in vitro antiviral activity against a broad spectrum of herpesviruses: HSV-1, HSV-2, HCMV, VZV, EBV, and HHV-6A/B, and in vivo activity in a murine microbiocide model of genital HSV-2 infection. The activity of these agents against animal cytomegalovirus (CMV) infections in vitro and in vivo was therefore investigated.</p> <p>Results</p> <p>In vitro, a 40 mer degenerate AP (REP 9) inhibited both murine CMV (MCMV) and guinea pig CMV (GPCMV) with an IC₅₀of 0.045 μM and 0.16 μM, respectively, and a 40 mer poly C AP (REP 9C) inhibited MCMV with an IC₅₀of 0.05 μM. Addition of REP 9 to plaque assays during the first two hours of infection inhibited 78% of plaque formation whereas addition of REP 9 after 10 hours of infection did not significantly reduce the number of plaques, indicating that REP 9 antiviral activity against MCMV occurs at early times after infection. In a murine model of CMV infection, systemic treatment for 5 days significantly reduced virus replication in the spleens and livers of infected mice compared to saline-treated control mice. REP 9 and REP 9C were administered intraperitoneally for 5 consecutive days at 10 mg/kg, starting 2 days prior to MCMV infection. Splenomegaly was observed in infected mice treated with REP 9 but not in control mice or in REP 9 treated, uninfected mice, consistent with mild CpG-like activity. When REP 9C (which lacks CpG motifs) was compared to REP 9, it exhibited comparable antiviral activity as REP 9 but was not associated with splenomegaly. This suggests that the direct antiviral activity of APs is the predominant therapeutic mechanism <it>in vivo</it>. Moreover, REP 9C, which is acid stable, was effective when administered orally in combination with known permeation enhancers.</p> <p>Conclusion</p> <p>These studies indicate that APs exhibit potent, well tolerated antiviral activity against CMV infection in vivo and represent a new class of broad spectrum anti-herpetic agents.</p