Testing Non-local Nucleon-Nucleon Interactions in the Four-Nucleon Systems

The Faddeev-Yakubovski equations are solved in configuration space for the $\alpha$-particle and n-$^3$H continuum states. We test the ability of nonlocal nucleon-nucleon interaction models to describe 3N and 4N systems.Comment: 16 pages, 6 figure

The importance of few-nucleon physics at low energy

This manuscript originated from the discussion at the workshop on the "Future of Few-body Low Energy Experimental Physics" (FFLEEP), which was held at the University of Trento on December 4-7, 2002 and has been written in its present form on March 19, 2003. It illustrates a selection of theoretical advancements in the nuclear few-body problem, including two- and many-nucleon interactions, the three-nucleon bound and scattering system, the four-body problem, the A-body (A$>$4) problem, and fields of related interest, such as reactions of astrophysical interest and few-neutron systems. Particular attention is called to the contradictory situation one experiences in this field: while theory is currently advancing and has the potential to inspire new experiments, the experimental activity is nevertheless rapidly phasing out. If such a trend will continue, advancements in this area will become critically difficult.Comment: 29 pages, 21 figures. Manuscript originated from the discussion at the workshop on the "Future of Few-body Low Energy Experimental Physics" (FFLEEP), University of Trento, December 4-7, 2002, written in its present form on March 19, 2003, circulated mainly among the participants to the FFLEEP workshop. Since the authors have been repeatedly solicited to make the manuscript accessible to a larger audience potentially interested in its scientific content, they have decided to post it on this archiv

Bethe-Salpeter equation for doubly heavy baryons in the covariant instantaneous approximation

In the heavy quark limit, a doubly heavy baryon is regarded as composed of a heavy diquark and a light quark. We establish the Bethe-Salpeter (BS) equations for the heavy diquarks and the doubly heavy baryons, respectively, to leading order in a $1/m_{Q}$ expansion. The BS equations are solved numerically under the covariant instantaneous approximation with the kernels containing scalar confinement and one-gluon-exchange terms. The masses for the heavy diquarks and the doubly heavy baryons are obtained and the non-leptonic decay widths for the doubly heavy baryons emitting a pseudo-scalar meson are calculated within the model.Comment: Corrections to the text, two references added, version accepted for publication in Physical Review

Infiltrative microgliosis: activation and long-distance migration of subependymal microglia following periventricular insults

BACKGROUND: Subventricular microglia (SVMs) are positioned at the interface of the cerebrospinal fluid and brain parenchyma and may play a role in periventricular inflammatory reactions. However, SVMs have not been previously investigated in detail due to the lack of a specific methodology for their study exclusive of deeper parenchymal microglia. METHODS: We have developed and characterized a novel model for the investigation of subventricular microglial reactions in mice using intracerebroventricular (ICV) injection of high-dose rhodamine dyes. Dynamic studies using timelapse confocal microscopy in situ complemented the histopathological analysis. RESULTS: We demonstrate that high-dose ICV rhodamine dye injection resulted in selective uptake by the ependyma and ependymal death within hours. Phagocytosis of ependymal debris by activated SVMs was evident by 1d as demonstrated by the appearance of rhodamine-positive SVMs. In the absence of further manipulation, labelled SVMs remained in the subventricular space. However, these cells exhibited the ability to migrate several hundred microns into the parenchyma towards a deafferentation injury of the hippocampus. This "infiltrative microgliosis" was verified in situ using timelapse confocal microscopy. Finally, supporting the disease relevance of this event, the triad of ependymal cell death, SVM activation, and infiltrative microgliosis was recapitulated by a single ICV injection of HIV-1 tat protein. CONCLUSIONS: Subependymal microglia exhibit robust activation and migration in periventricular inflammatory responses. Further study of this population of microglia may provide insight into neurological diseases with tendencies to involve the ventricular system and periventricular tissues

Four-nucleon scattering: Ab initio calculations in momentum space

The four-body equations of Alt, Grassberger and Sandhas are solved for \nH scattering at energies below three-body breakup threshold using various realistic interactions including one derived from chiral perturbation theory. After partial wave decomposition the equations are three-variable integral equations that are solved numerically without any approximations beyond the usual discretization of continuum variables on a finite momentum mesh. Large number of two-, three- and four-nucleon partial waves are considered until the convergence of the observables is obtained. The total \nH cross section data in the resonance region is not described by the calculations which confirms previous findings by other groups. Nevertheless the numbers we get are slightly higher and closer to the data than previously found and depend on the choice of the two-nucleon potential. Correlations between the $A_y$ deficiency in \nd elastic scattering and the total \nH cross section are studied.Comment: Corrected Eq. (10

Human visual sampling processes - A simulation validation study

Pilots and flight simulator used in study of human visual sampling stud

Antiproton-Hydrogen annihilation at sub-kelvin temperatures

The main properties of the interaction of ultra low-energy antiprotons ($E\le10^{-6}$ a.u.) with atomic hydrogen are established. They include the elastic and inelastic cross sections and Protonium (Pn) formation spectrum. The inverse Auger process ($Pn+e \to H+\bar{p}$) is taken into account in the framework of an unitary coupled-channels model. The annihilation cross-section is found to be several times smaller than the predictions made by the black sphere absorption models. A family of $\bar{p}H$ nearthreshold metastable states is predicited. The dependence of Protonium formation probability on the position of such nearthreshold S-matrix singularities is analysed. An estimation for the $H\bar{H}$ annihilation cross section is obtained.Comment: latex.tar.gz file, 22 pages, 9 figure

The Vascular Basement Membrane as “Soil” in Brain Metastasis

Brain-specific homing and direct interactions with the neural substance are prominent hypotheses for brain metastasis formation and a modern manifestation of Paget's “seed and soil” concept. However, there is little direct evidence for this “neurotropic” growth in vivo. In contrast, many experimental studies have anecdotally noted the propensity of metastatic cells to grow along the exterior of pre-existing vessels of the CNS, a process termed vascular cooption. These observations suggest the “soil” for malignant cells in the CNS may well be vascular, rather than neuronal. We used in vivo experimental models of brain metastasis and analysis of human clinical specimens to test this hypothesis. Indeed, over 95% of early micrometastases examined demonstrated vascular cooption with little evidence for isolated neurotropic growth. This vessel interaction was adhesive in nature implicating the vascular basement membrane (VBM) as the active substrate for tumor cell growth in the brain. Accordingly, VBM promoted adhesion and invasion of malignant cells and was sufficient for tumor growth prior to any evidence of angiogenesis. Blockade or loss of the β1 integrin subunit in tumor cells prevented adhesion to VBM and attenuated metastasis establishment and growth in vivo. Our data establishes a new understanding of CNS metastasis formation and identifies the neurovasculature as the critical partner for such growth. Further, we have elucidated the mechanism of vascular cooption for the first time. These findings may help inform the design of effective molecular therapies for patients with fatal CNS malignancies

Solutions of the Faddeev-Yakubovsky equations for the four nucleons scattering states

The Faddeev-Yakubowsky equations in configuration space have been solved for the four nucleon system. The results with an S-wave interaction model in the isospin approximation are presented. They concern the bound and scattering states below the first three-body threshold. The elastic phase-shifts for the N+NNN reaction in different ($S,T$) channels are given and the corresponding low energy expansions are discussed. Particular attention is payed to the n+t elastic cross section. Its resonant structure is well described in terms of a simple NN interaction. First results concerning the S-matrix for the coupled N+NNN-NN+NN channels and the strong deuteron-deuteron scattering length are obtained.Comment: latex.tar.gz, 36 pages, 10 figures, 11 tables. To be published in Physical Review

Coulomb corrections to low energy antiproton annihilation cross sections on protons and nuclei

We calculate, in a systematic way, the enhancement effect on antiproton-proton and antiproton-nucleus annihilation cross sections at low energy due to the initial state electrostatic interaction between the projectile and the target nucleus. This calculation is aimed at future comparisons between antineutron and antiproton annihilation rates on different targets, for the extraction of pure isospin channels.Comment: 18 pages, 4 figures (latex format