Thermal Performance Assessment of an Opaque Ventilated Façade in the Summer Period: Calibration of a Simulation Model through in-field Measurements

In recent years, several studies have been performed to evaluate the actual contribute of Opaque Ventilated Façades (OVF) as far as the energy efficiency of buildings in the summer period is concerned. In this framework an experimental real-scale module of an OVF was built and tested. Results demonstrated a reduction of ~58% of the thermal load obtained by using a OVF with respect to the unventilated façade configuration. In this paper the experimental measurements were used to calibrate dynamic simulations using ESP-r software, in order to identify the input factors and the key issues mainly impacting on the results discrepancy

Energy Assessment of A PCM–Embedded Plaster: Embodied Energy Versus Operational Energy

Phase change materials (PCMs) are an emerging technology that can be integrated in building envelope components. PCMs are able to stabilise indoor air temperature and increase thermal energy storage especially in lightweight constructions. Within a research activity aimed at developing advanced plasters with improved thermal properties, a plaster which incorporates a microencapsulated paraffin-based PCM was developed. The paper highlights the importance of an overall analysis, facing both operational and embodied energy, since the expected decrease of the energy consumption during the operational stage difficultly counterbalances the high energy impact related to manufacturing processes

Development of Vegetal Based Thermal Plasters with Low Environmental Impact: Optimization Process through an Integrated Approach

The use of thermal insulating plasters represents an effective solution in energy retrofit of existing buildings. Thermal properties are usually improved through the addition on the plaster formulation of Light Weight Aggregates, as expanded polystyrene and perlite. The drawback of these thermal plasters is the higher environmental impact, especially when added to natural binders, as natural hydraulic lime. Within a research activity a process of optimization was followed in order to get the most effective blend, applying iteratively the LCA methodology, measuring the thermal conductivity and testing the environmental impact in terms of Volatile Organic Compounds and formaldehyde emission rates

Performance of a fully automatic lesion detection system for breast DCE-MRI

PURPOSE: To describe and test a new fully automatic lesion detection system for breast DCE-MRI. MATERIALS AND METHODS: Studies were collected from two institutions adopting different DCE-MRI sequences, one with and the other one without fat-saturation. The detection pipeline consists of (i) breast segmentation, to identify breast size and location; (ii) registration, to correct for patient movements; (iii) lesion detection, to extract contrast-enhanced regions using a new normalization technique based on the contrast-uptake of mammary vessels; (iv) false positive (FP) reduction, to exclude contrast-enhanced regions other than lesions. Detection rate (number of system-detected malignant and benign lesions over the total number of lesions) and sensitivity (system-detected malignant lesions over the total number of malignant lesions) were assessed. The number of FPs was also assessed. RESULTS: Forty-eight studies with 12 benign and 53 malignant lesions were evaluated. Median lesion diameter was 6 mm (range, 5-15 mm) for benign and 26 mm (range, 5-75 mm) for malignant lesions. Detection rate was 58/65 (89%; 95% confidence interval [CI] 79%-95%) and sensitivity was 52/53 (98%; 95% CI 90%-99%). Mammary median FPs per breast was 4 (1st-3rd quartiles 3-7.25). CONCLUSION: The system showed promising results on MR datasets obtained from different scanners producing fat-sat or non-fat-sat images with variable temporal and spatial resolution and could potentially be used for early diagnosis and staging of breast cancer to reduce reading time and to improve lesion detection. Further evaluation is needed before it may be used in clinical practice

Dendritic cell vaccination in metastatic melanoma turns \u201cnon-T cell inflamed\u201d into \u201cT-cell inflamed\u201d tumors

Dendritic cell (DC)-based vaccination effectively induces anti-tumor immunity, although in the majority of cases this does not translate into a durable clinical response. However, DC vaccination is characterized by a robust safety profile, making this treatment a potential candidate for effective combination cancer immunotherapy. To explore this possibility, understanding changes occurring in the tumor microenvironment (TME) upon DC vaccination is required. In this line, quantitative and qualitative changes in tumor-infiltrating T lymphocytes (TILs) induced by vaccination with autologous tumor lysate/homogenate loaded DCs were investigated in a series of 16 patients with metastatic melanoma. Immunohistochemistry for CD4, CD8, Foxp3, Granzyme B (GZMB), PDL1, and HLA class I was performed in tumor biopsies collected before and after DC vaccination. The density of each marker was quantified by automated digital pathology analysis on whole slide images. Co-expression of markers defining functional phenotypes, i.e., Foxp3+ regulatory CD4+ T cells (Treg) and GZMB+ cytotoxic CD8+ T cells, was assessed with sequential immunohistochemistry. A significant increase of CD8+ TILs was found in post-vaccine biopsies of patients who were not previously treated with immune-modulating cytokines or Ipilimumab. Interestingly, along with a maintained tumoral HLA class I expression, after DC vaccination we observed a significant increase of PDL1+ tumor cells, which significantly correlated with intratumoral CD8+ T cell density. This observation might explain the lack of a significant concurrent cytotoxic reactivation of CD8+ T cell, as measured by the numbers of GZMB+ T cells. Altogether these findings indicate that DC vaccination exerts an important role in sustaining or de novo inducing a T cell inflamed TME. However, the strength of the intratumoral T cell activation detected in post-DC therapy lesions is lessened by an occurring phenomenon of adaptive immune resistance, yet the concomitant PDL1 up-regulation. Overall, this study sheds light on DC immunotherapy-induced TME changes, lending the rationale for the design of smarter immune-combination therapies

SHARK-NIR, the coronagraphic camera for LBT, moving toward construction

SHARK-NIR is one of the two coronagraphic instruments proposed for the Large Binocular Telescope. Together with SHARK-VIS (performing coronagraphic imaging in the visible domain), it will offer the possibility to do binocular observations combining direct imaging, coronagraphic imaging and coronagraphic low resolution spectroscopy in a wide wavelength domain, going from 0.5{\mu}m to 1.7{\mu}m. Additionally, the contemporary usage of LMIRCam, the coronagraphic LBTI NIR camera, working from K to L band, will extend even more the covered wavelength range. In January 2017 SHARK-NIR underwent a successful final design review, which endorsed the instrument for construction and future implementation at LBT. We report here the final design of the instrument, which foresees two intermediate pupil planes and three focal planes to accomodate a certain number of coronagraphic techniques, selected to maximize the instrument contrast at various distances from the star. Exo-Planets search and characterization has been the science case driving the instrument design, but the SOUL upgrade of the LBT AO will increase the instrument performance in the faint end regime, allowing to do galactic (jets and disks) and extra-galactic (AGN and QSO) science on a relatively wide sample of targets, normally not reachable in other similar facilities.Comment: 8 pages, 6 figures, AO4ELT5 conference proceeding

SHARK-NIR: from K-band to a key instrument, a status update

SHARK-NIR channel is one of the two coronagraphic instruments proposed for the Large Binocular Telescope, in the framework of the call for second generation instruments, issued in 2014. Together with the SHARK-VIS channel, it will offer a few observing modes (direct imaging, coronagraphic imaging and coronagraphic low resolution spectroscopy) covering a wide wavelength domain, going from 0.5μm to 1.7μm. Initially proposed as an instrument covering also the K-band, the current design foresees a camera working from Y to H bands, exploiting in this way the synergy with other LBT instruments such as LBTI, which is actually covering wavelengths greater than L' band, and it will be soon upgraded to work also in K band. SHARK-NIR has been undergoing the conceptual design review at the end of 2015 and it has been approved to proceed to the final design phase, receiving the green light for successive construction and installation at LBT. The current design is significantly more flexible than the previous one, having an additional intermediate pupil plane that will allow the usage of coronagraphic techniques very efficient in term of contrast and vicinity to the star, increasing the instrument coronagraphic performance. The latter is necessary to properly exploit the search of giant exo-planets, which is the main science case and the driver for the technical choices of SHARK-NIR. We also emphasize that the LBT AO SOUL upgrade will further improve the AO performance, making possible to extend the exo-planet search to target fainter than normally achieved by other 8-m class telescopes, and opening in this way to other very interesting scientific scenarios, such as the characterization of AGN and Quasars (normally too faint to be observed) and increasing considerably the sample of disks and jets to be studied. Finally, we emphasize that SHARK-NIR will offer XAO direct imaging capability on a FoV of about 15"x15", and a simple coronagraphic spectroscopic mode offering spectral resolution ranging from few hundreds to few thousands. This article presents the current instrument design, together with the milestones for its installation at LBT. <P /

T-REX OU4 HIRES: the high resolution spectrograph for the E-ELT

The goal of this unit was to consolidate the project for the construction of the high resolution spectrometer of the E-ELT (HIRES). The task included the development of scientific cases and tools to predict the instrumental performances. From the technical point of view it included several R&D activities in collaboration with highly specialized Italian companies; it culminated with the detailed design of a highly modular instrument based on well established technologies. From the management point of view it lead to the consolidation of a large international consortium that spans over 12 countries and includes most of the European and ESO-related institutes interested in high resolution spectroscopy. This consortium is led by INAF; its formal creation is awaiting the official call by ESO for the phase-A study for the HIRES instrument of the E-ELT

Hedgehog signalling in CD8+ T cell memory

[Restricted]Cancer Research U

An experimental sensitivity analysis on the summer thermal performance of an Opaque Ventilated Façade

In the last few years opaque ventilated façades (OVFs) have reached an increasing diffusion in theMediterranean area for their capability of reducing the heat flux across the building envelope in summerconditions as well as preventing the condensation and infiltration risk in the winter period providingwind and rain protection, thus increasing the durability of the façade. Moreover, the possibility to hostdifferent cladding allows architects to explore a wide range of façade combinations. In the frameworkof a regional funded project, an extensive in-field experimental campaign was carried out in the summerperiod on different full-scale OVF configurations, with the aim of assessing the thermal performance of anewly developed OVF based on hollow clay claddings technology.A sensitivity analysis was thus performed, in order to evaluate, on the one hand, the effect on the per-formance of the main façade features, e.g. ventilation channel height, solar absorption coefficient andventilation grills openings ratio, and on the other hand, the influence of the outdoor boundary conditions,e.g. solar radiation and external air temperature.The experimental results highlight that the façade configuration and the design features significantlyaffect the capability of OVFs on minimising the solar heat loads across the wall (between~30%and~70%) if compared to an unventilated façade (representing the reference configuration). These resultsallow providing general guidelines for an optimised OVF design. Moreover, the assessment of the effect ofthe outdoor boundary conditions allowed to identify the conditions in which the façade shows the higherexploitation of natural ventilation