2,2,7-Trichloro-3,4-dihydro­naphthalen-1(2H)-one

The title compound, C10H7Cl3O, obtained as a major byproduct from a classical Schmidt reaction. The cyclohexyl ring is distorted from a classical chair conformation, as observed for monocyclic analogues, presumably due to conjugation of the planar annulated benzo ring and the ketone group (r.m.s. deviation 0.024 Å). There are no significant intermolecular interactions

A rock physics and seismic tomography study to characterize the structure of the Campi Flegrei caldera

The Campi Flegrei (CF) caldera experiences dramatic ground deformations unsurpassed anywhere in the world. The source responsible for this phenomenon is still debated. With the aim of exploring the structure of the caldera as well as the role of hydrothermal fluids on velocity changes, a multidisciplinary approach dealing with 3-D delay-time tomography and rock physics characterization has been followed. Selected seismic data were modeled by using a tomographic method based on an accurate finite-difference travel-time computation which simultaneously inverts P-wave and S-wave first-arrival times for both velocity model parameters and hypocenter locations. The retrieved P-wave and S-wave velocity images as well as the deduced Vp/Vs images were interpreted by using experimental measurements of rock physical properties on CF samples, to take into account steam/water phase transition mechanisms affecting P-wave and S-wave velocities. Also, modelling of petrophysical properties for site-relevant rocks constrains the role of overpressured fluids on velocity. A flat and low Vp/Vs anomaly lies at 4 km depth under the city of Pozzuoli. Earthquakes are located at the top of this anomaly. This anomaly implies the presence of fractured over-pressured gas-bearing formations and excludes the presence of melted rocks. At shallow depth, a high Vp/Vs anomaly located at 1 km suggests the presence of rocks containing fluids in the liquid phase. Finally, maps of the Vp*Vs product show a high Vp*Vs horse-shoe shaped anomaly located at 2 km depth. It is consistent with gravity data and well data and might constitute the on-land remainder of the caldera rim, detected below sea level by tomography using active source seismic data. For a more exhaustive description of the utilized methodologies, of synthetic tests for spatial resolution and uncertainty assessment and, the interpretation of results, the reader may refer to the paper Vanorio et al. (2005)

8-Chloro-5-(4-phenethylpiperazin-1-­yl)pyrido[2,3-b][1,5]benzoxazepine

As part of an anti­psychotic drug discovery program, we report the crystal structure of the title compound, C24H23ClN4O. The mol­ecule has a tricyclic framework with a characteristic buckled V-shaped pyridobenzoxazepine unit, with the central seven-membered heterocycle in a boat configuration. The piperazine ring displays a chair conformation with the 2-phenyl-ethyl substituent assuming an equatorial orientation. There are two crystallographically independent, but virtually identical, mol­ecules in the asymmetric unit

Di-tert-butyl N-[2,6-bis­(methoxy­meth­oxy)phen­yl]imino­diacetate

The title mol­ecule, C20H31NO8, has pseudo-C2 symmetry about the C—N bond, with the bis­(tert-butoxy­carbon­yl)amino group twisted from the benzene ring plane by ca 60° and the bulky tert-butoxy­carbonyl (Boc) groups are orientated away from the substituted aniline group. As part of an anti­bacterial drug discovery programme furnishing analogues of platensimycin, we unexpectedly synthesized the bis-Boc-protected aniline

Recent results from the G(0) experiment

We have measured parity violating asymmetries in elastic electron-proton and quasi-elastic electron-deuteron scattering at backward electron angle. These measurements have been done at two momentum transfers : Q(2) = 0.22 and 0.63 (GeV/c)(2). Together with our previous forward angle measurement [1], we can extract strange quark contributions to the electromagnetic form factors of the nucleon, as well as nucleon axial form factor coming from the neutral weak interaction. The results indicate a strange quark magnetic contribution close to zero at these Q(2), and a possible non zero strange quark electric contribution for the high Q(2). The first Q(2) behavior measurement of the nucleon axial form factor in elastic electron scattering shows a good agreement with radiative corrections calculated at Q(2) = 0 and with a dipole form using the axial mass determined in neutrino scattering

Consolidation of Geologic Studies of Geopressured Geothermal Resources in Texas

The objective of the current studies at the Pleasant Bayou geopressured geothermal reservoir in Brazoria County, Texas, was to evaluate the resource base and long-term performance. The approach was to develop an integrated understanding of the hydrogeology of the reservoir and the hydrochemistry of the produced brine. Such an understanding would allow determination of the extent of lateral and vertical hydrologic continuity of the target zone and to identify the sources of brine being produced from the geopressured reservoir. The current phase of long-term production testing of the Frio C-zone at Pleasant Bayou Well No. 2 began in May 1988. During the past 16 months of production, nearly 6.8 million barrels of brine and 162.2 million cubic feet of gas have been produced, and a relatively small (less than 300 psi) drop in bottom-hole pressure has been observed at sustained producing rates of between 15,000 and 20,000 barrels per day. Earlier geologic studies have estimated the effective pore volume of the C-zone in the neighborhood of 6.2 to 6.6 billion barrels. Analysis of pressure and production data from current testing indicates that the limits of the geopressured reservoir at Pleasant Bayou have not been reached; that is, either the size of the reservoir could be larger than anticipated, or there could be a continuous influx of waters from other geopressured sources that sustains the reservoir energy at Pleasant Bayou. Geochemical testing has proved inconclusive in identifying other sources of water partly because of the variability of chemical composition within the produced zone. Evaluation of reservoir performance at active oil and gas fields in the immediate vicinity of the Pleasant Bayou fault block has not provided evidence of direct hydrologic communication between the geopressured aquifer and the overlying hydrocarbon reservoirs. The pattern of depletion in these oil and gas fields reflects some characteristic features that may become evident in Pleasant Bayou over a long period of production. Moreover, additional refinement of the integrated hydrogeologic-hydrochemical model is possible either through prolonged testing at Pleasant Bayou No. 2 well or through drilling and testing of additional wells in the Pleasant Bayou fault block. Determining the nature of bounding faults around the test well will require additional seismic data as well as multiwell testing of the reservoir.Bureau of Economic Geolog

Measurement of the Parity-Violating Asymmetry in Inclusive Electroproduction of pi(-) near the Delta(0) Resonance

The parity-violating (PV) asymmetry of inclusive pi(-) production in electron scattering from a liquid deuterium target was measured at backward angles. The measurement was conducted as a part of the G0 experiment, at a beam energy of 360 MeV. The physics process dominating pion production for these kinematics is quasifree photoproduction off the neutron via the Delta(0) resonance. In the context of heavy-baryon chiral perturbation theory, this asymmetry is related to a low-energy constant d(Delta)(-) that characterizes the parity-violating gamma N Delta coupling. Zhu et al. calculated d(Delta)(-) in a model benchmarked by the large asymmetries seen in hyperon weak radiative decays, and predicted potentially large asymmetries for this process, ranging from A(gamma)(-) = -5.2 to + 5.2 ppm. The measurement performed in this work leads to A(gamma)(-) = -0.36 +/- 1.06 +/- 0.37 +/- 0.03 ppm (where sources of statistical, systematic and theoretical uncertainties are included), which would disfavor enchancements considered by Zhu et al. proportional to V-ud/V-us. The measurement is part of a program of inelastic scattering measurements that were conducted by the G0 experiment, seeking to determine the N - Delta axial transition form factors using PV electron scattering

A 3D velocity model for earthquake location in Campi Flegrei area: application to the 1982-84 uplift event

The uplift crisis of the 1982-1984 in the Campi Flegrei area underlined the importance of seismic surveillance for this volcanic caldera. One of the key elements for an effective seismic network is to make use of a reliable velocity model for earthquake location. In the present work we will discuss criteria for the construction and validation of a new 3D P-wave velocity model for earthquake location in the Campi Flegrei area built from the integration of two high-resolution 3D tomographic images of the region. The model is used for locating a group of earthquakes from the uplift event of the 1982-1984

Fortnightly variability of Chl <i>a</i> in the Indonesian seas

Twenty years of daily MODIS-Aqua ocean color observations (2002–2022) are used to identify periodic variability of near-surface chlorophyll (Chl a) in the Indonesian seas. The frequency spectrum of Chl a is dominated by the mean and low-frequency monsoonal variability; however, a prominent peak around the fortnightly tidal period, MSf, is present. Harmonic analysis is used to quantify and map the fortnightly Chl a signal, which is discovered to be significant along the continental shelves of NW Australia and at several sites associated with narrow passages between the Lesser Sunda Islands, within the Sulu Archipelago, and at a few other sites in the Philippines Archipelago. Fortnightly variability at the shallow coastal sites is attributed to the spring–neap cycle of barotropic ocean currents, while we hypothesize that the variability in deeper water near the island passages is due to the modulation of vertical nutrient fluxes by baroclinic tidal mixing. The results document the significance of tidal mixing and highlight the heterogeneous character of biophysical processes within the Indonesian seas.</p

ANALISI DEI CONSUMI DI STUPEFACENTI E POPOLAZIONE DEL SERT DI TERMINI IMERESE FINALIZZATA ALL’ATTIVAZIONE DI UN PROGETTO EDUCAZIONALE

Introduzione. In questo studio è stato preso in considerazione il consumo annuale di stupefacenti (metadone e buprenorfina) dal 2009 al 2012, da parte del Ser.T di Termini Imerese. Si è voluto indagare sulla tipologia di pazienti ambulatoriali per avviare un successivo progetto di prevenzione rivolto alle scuole. Materiali e metodi: I dati relativi ai consumi sono stati estrapolati dal programma di magazzino del polo di distribuzione di Termini Imerese, mentre i dati relativi ai pazienti sono stati ricavati dal Sistema Informativo Sanitario del Ministero della Salute consultabile dai dipendenti del Ser.T. Risultati: I consumi di metadone cloridrato flacone da 20 ml 0,1% sono progressivamente aumentati dal 2009 al 2011 subendo una contrazione nel 2012 (42.000 flaconi consegnati nel 2009, 50.000 nel 2010, 54.300 nel 2011, 48.500 nel 2012); si è registrata una riduzione dei consumi di buprenorfina probabilmente imputabile all’utilizzo iniziale della formulazione in cui non era presente l’associazione con naloxone (2.240 cpr suboxone e 3.780 cpr subutex da 2 mg fornite nel 2009, 6.370, 5.880 e 5.040 cpr di suboxone da 2 mg fornite rispettivamente nel 2010, 2011 e 2012; 3.080 suboxone e 3.360 cpr subutex da 8 mg fornite nel 2009, 6.020, 3.220 e 3.150 cpr di suboxone da 8 mg fornite rispettivamente nel 2010, 2011 e 2012). Il numero di pazienti totali si è mantenuto costante (129 pazienti/anno, valore medio dei 4 anni). La maggior parte aveva un basso livello di istruzione (il 48,8% aveva conseguito il diploma di scuola media inferiore e il 32,6% la licenza elementare). Il numero di pazienti trattati con metadone è aumentato gradualmente passando da 80 a 95 dal 2009 al 2012. Erano soprattutto uomini (94,8% maschi, 5,2% femmine), di età compresa tra i 17 e i 55 anni. Avevano fatto principalmente uso di eroina nonostante alcuni facessero contemporaneo uso di altre sostanze (cocaina, cannabinoidi, metadone, altri oppiacei). Nella maggior parte dei casi le sostanze di iniziazione sono state cannabinoidi. Conclusioni: Il problema delle tossicodipendenze è ancora oggi grave e diffuso come si evince dai consumi di stupefacenti e dall’indagine condotta al SERT. Un’efficace educazione preventiva sulla tossicodipendenza è vitale per diminuire il numero di persone che ogni anno iniziano a far uso di droghe. Sarebbe quindi auspicabile intraprendere iniziative di informazione e prevenzione rivolte ai giovani ma anche ai genitori. In quest’ottica la figura del farmacista, in quanto esperto del farmaco, dei prodotti naturali e chimici potrebbe diventare un valido strumento di informazione e conoscenza