230 research outputs found
ROSAT and ASCA observations of the Crab-Like Supernova Remnant N157B in the Large Magellanic Cloud
We report the results of ROSAT and ASCA X-ray observations of the supernova
remnant N157B (or 30 Dor B, SNR 0539-69.1) in the Large Magellanic Cloud. For
comparison, we also briefly describe the results on SNR 0540-69.3, the only
confirmed Crab-like remnant in the Cloud. The X-ray emission from N157B can be
decomposed into a bright comet-shaped feature, superimposed on a diffuse
emission region of a dimension pc. The flat and nearly featureless
spectrum of the remnant is distinctly different from those of young shell-like
remnants, suggesting a predominantly Crab-like nature of N157B. Characterized
by a power law with an energy slope , the spectrum of N157B above
keV is, however, considerably steeper than that of SNR 0540-69.3,
which has a slope of . At lower energies, the spectrum of N157B
presents marginal evidence for emission lines, which if real most likely arise
in hot gas of the diffuse emission region. The hot gas has a characteristic
thermal temperature of 0.4-0.7 keV. No significant periodic signal is detected
from N157B in the period range of s. The pulsed
fraction is (99% confidence) in the keV range. We discuss
the nature of the individual X-ray components. In particular, we suggest that
the synchrotron radiation of relativistic particles from a fast-moving () pulsar explains the size, morphology, spectrum, and energetics
of the comet-shaped X-ray feature. We infer the age of the remnant as yrs. The lack of radio polarization of the remnant may be due to
Faraday dispersion by foreground \ion{H}{2} gas.Comment: To be published in The Astrophysical Journal, 21 pages, plus 11
images in the PS, GIF, or jpeg format. Postscript files of images are
available at http://www.astro.nwu.edu/astro/wqd/paper/n157b
Use of Shared Faculty in U.S. and Canadian Dental Schools
Dental schools are facing substantial financial challenges and a shortage of faculty members. One solution to address these issues has been to hire “shared” faculty members, i.e., faculty members whose primary appointment is at one institution who are hired by another institution to teach a course or part of a course. This is a controversial concept. A survey of academic deans at U.S. and Canadian dental schools was conducted for this study; thirty-nine (54 percent) of the seventy-two academic deans completed the online survey. This survey found that the use of shared faculty members is not rare amongst U.S. and Canadian dental schools and that the opinions of the academic deans about the use of shared faculty members ranged widely—from strong support to strong disapproval. Using shared faculty members has advantages and disadvantages for students, the shared faculty members, and both institutions. Many of the disadvantages could be potentially minimized by stakeholders’ working together to develop collaborative arrangements. Networks could be developed in which institutions coordinate hiring of shared faculty members based on what expertise is needed. Financial challenges and shortages of faculty members are unlikely to be resolved in the near future, but use of shared faculty members is one promising approach to begin to meet these challenges
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Chloride channels regulate differentiation and barrier functions of the mammalian airway.
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction leads to early onset airway diseases, remain unclear. In this study, we systematically characterized the developmental landscape of the mouse airway using single-cell RNA sequencing and identified remarkably conserved cellular programs operating during human fetal development. We demonstrated that in mouse, genetic inactivation of chloride channel Ano1/Tmem16a compromises airway barrier function, results in early signs of inflammation, and alters the airway cellular landscape by depleting epithelial progenitors. Mouse Ano1-/-mutants exhibited mucus obstruction and abnormal mucociliary clearance that resemble the airway defects associated with cystic fibrosis. The data reveal critical and non-redundant roles for Ano1 in organogenesis, and show that chloride channels are essential for mammalian airway formation and function
The Relationship Between Self-Reported History of Endodontic Therapy and Coronary Heart Disease in the Atherosclerosis Risk in Communities Study
Results from numerous studies have suggested links between periodontal disease and coronary heart disease (CHD), but endodontic disease has not been studied extensively in this regard
The Incidence of Highly-Obscured Star-Forming Regions in SINGS Galaxies
Using the new capabilities of the Spitzer Space Telescope and extensive
multiwavelength data from the Spitzer Infrared Nearby Galaxies Survey (SINGS),
it is now possible to study the infrared properties of star formation in nearby
galaxies down to scales equivalent to large HII regions. We are therefore able
to determine what fraction of large, infrared-selected star-forming regions in
normal galaxies are highly obscured and address how much of the star formation
we miss by relying solely on the optical portion of the spectrum. Employing a
new empirical method for deriving attenuations of infrared-selected
star-forming regions we investigate the statistics of obscured star formation
on 500pc scales in a sample of 38 nearby galaxies. We find that the median
attenuation is 1.4 magnitudes in H-alpha and that there is no evidence for a
substantial sub-population of uniformly highly-obscured star-forming regions.
The regions in the highly-obscured tail of the attenuation distribution
(A_H-alpha > 3) make up only ~4% of the sample of nearly 1800 regions, though
very embedded infrared sources on the much smaller scales and lower
luminosities of compact and ultracompact HII regions are almost certainly
present in greater numbers. The highly-obscured cases in our sample are
generally the bright, central regions of galaxies with high overall attenuation
but are not otherwise remarkable. We also find that a majority of the galaxies
show decreasing radial trends in H-alpha attenuation. The small fraction of
highly-obscured regions seen in this sample of normal, star-forming galaxies
suggests that on 500pc scales the timescale for significant dispersal or break
up of nearby, optically-thick dust clouds is short relative to the lifetime of
a typical star-forming region.Comment: Accepted for publication in ApJ; emulateapj style, 30 pages, 18
figures (compressed versions), 3 table
The Nature of Infrared Emission in the Local Group Dwarf Galaxy NGC 6822 As Revealed by Spitzer
We present Spitzer imaging of the metal-deficient (Z ~30% Z_sun) Local Group
dwarf galaxy NGC 6822. On spatial scales of ~130 pc, we study the nature of IR,
H alpha, HI, and radio continuum emission. Nebular emission strength correlates
with IR surface brightness; however, roughly half of the IR emission is
associated with diffuse regions not luminous at H alpha (as found in previous
studies). The global ratio of dust to HI gas in the ISM, while uncertain at the
factor of ~2 level, is ~25 times lower than the global values derived for
spiral galaxies using similar modeling techniques; localized ratios of dust to
HI gas are about a factor of five higher than the global value in NGC 6822.
There are strong variations (factors of ~10) in the relative ratios of H alpha
and IR flux throughout the central disk; the low dust content of NGC 6822 is
likely responsible for the different H alpha/IR ratios compared to those found
in more metal-rich environments. The H alpha and IR emission is associated with
high-column density (> ~1E21 cm^-2) neutral gas. Increases in IR surface
brightness appear to be affected by both increased radiation field strength and
increased local gas density. Individual regions and the galaxy as a whole fall
within the observed scatter of recent high-resolution studies of the radio-far
IR correlation in nearby spiral galaxies; this is likely the result of depleted
radio and far-IR emission strengths in the ISM of this dwarf galaxy.Comment: ApJ, in press; please retrieve full-resolution version from
http://www.astro.wesleyan.edu/~cannon/pubs.htm
Association of Endodontic Involvement with Tooth Loss in the Veterans Affairs Dental Longitudinal Study
The effect of endodontic involvement on tooth loss has not been quantified, so the present study aimed to assess this relationship after controlling for other relevant risk factors for tooth loss
Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity
Background: T-cell tolerance of allergic cutaneous contact
sensitivity (CS) induced in mice by high doses of reactive hapten
is mediated by suppressor cells that release antigen-specific
suppressive nanovesicles.
Objective: We sought to determine the mechanism or
mechanisms of immune suppression mediated by the
nanovesicles.
Methods: T-cell tolerance was induced by means of intravenous
injection of hapten conjugated to self-antigens of syngeneic
erythrocytes and subsequent contact immunization with the same
hapten. Lymph node and spleen cells from tolerized or control
donors were harvested and cultured to produce a supernatant
containing suppressive nanovesicles that were isolated from the
tolerized mice for testing in active and adoptive cell-transfer
models of CS.
Results: Tolerance was shown due to exosome-like nanovesicles
in the supernatants of CD81 suppressor T cells that were not
regulatory T cells. Antigen specificity of the suppressive
nanovesicles was conferred by a surface coat of antibody light
chains or possibly whole antibody, allowing targeted delivery of
selected inhibitory microRNA (miRNA)–150 to CS effector T
cells. Nanovesicles also inhibited CS in actively sensitized mice
after systemic injection at the peak of the responses. The role of
antibody and miRNA-150 was established by tolerizing either
panimmunoglobulin-deficient JH2/2 or miRNA-1502/2 mice
that produced nonsuppressive nanovesicles. These nanovesicles
could be made suppressive by adding antigen-specific antibody
light chains or miRNA-150, respectively.
Conclusions: This is the first example of T-cell regulation
through systemic transit of exosome-like nanovesicles delivering
a chosen inhibitory miRNA to target effector T cells in an
antigen-specific manner by a surface coating of antibody light
chains
Spitzer and JCMT Observations of the Active Galactic Nucleus in the Sombrero Galaxy (NGC 4594)
We present Spitzer 3.6-160 micron images, Spitzer mid-infrared spectra, and
JCMT SCUBA 850 micron images of the Sombrero Galaxy (NGC 4594), an Sa galaxy
with a 10^9 M_solar low luminosity active galactic nucleus (AGN). The brightest
infrared sources in the galaxy are the nucleus and the dust ring. The spectral
energy distribution of the AGN demonstrates that, while the environment around
the AGN is a prominent source of mid-infrared emission, it is a relatively weak
source of far-infrared emission, as had been inferred for AGN in previous
research. The weak nuclear 160 micron emission and the negligible polycyclic
aromatic hydrocarbon emission from the nucleus also implies that the nucleus is
a site of only weak star formation activity and the nucleus contains relatively
little cool interstellar gas needed to fuel such activity. We propose that this
galaxy may be representative of a subset of low ionization nuclear emission
region galaxies that are in a quiescent AGN phase because of the lack of gas
needed to fuel circumnuclear star formation and Seyfert-like AGN activity.
Surprisingly, the AGN is the predominant source of 850 micron emission. We
examine the possible emission mechanisms that could give rise to the 850 micron
emission and find that neither thermal dust emission, CO line emission,
bremsstrahlung emission, nor the synchrotron emission observed at radio
wavelengths can adequately explain the measured 850 micron flux density by
themselves. The remaining possibilities for the source of the 850 micron
emission include a combination of known emission mechanisms, synchrotron
emission that is self-absorbed at wavelengths longer than 850 microns, or
unidentified spectral lines in the 850 micron band.Comment: Accepted to ApJ, 200
Advancing specificity in delirium: The delirium subtyping initiative
BACKGROUND: Delirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology. METHODS: The Delirium Subtyping Initiative (DSI) held three sessions with an international panel of 25 experts. RESULTS: Meeting participants suggest further characterization of delirium features to complement the existing Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision diagnostic criteria. These should span the range of delirium-spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations. DISCUSSION: The DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes. HIGHLIGHTS: Delirium features must be clearly defined, standardized, and operationalized. Large datasets incorporating both clinical and biomarker variables should be analyzed together. Delirium screening should incorporate communication and reasoning
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