Regional E-Government - some problems from Czech regions point of view

The e-government should start with electronic collaboration of governmental departments. Several services, like email, video conference, discussion forums, use of shared documents, etc. should be supported for assisting the efficient and productive collaboration of remote governmental departments. Since the functionality of the provided services is well known, no detailed description of each service phase is provided. The services for citizens are offered through so called governmental portals. The typical use of a governmental portal is to provide information to the citizens and to support several types of citizen–government transactions (e.g. issuing birth certificates, submitting tax forms, conducting electronic payments, etc.). These services open security requirements for an e-Government platform. Their compilation has been based on the security requirements derived for each independent service suite, for the Authentication processes

Social-Economic Aspects of the Regional Development Within Transform Economics - Regional Development in CR After Year 1990.

In the beginning of the transformation CR i.e. after year 1990, with started always expressive display in plant regional differences resulting from transformation process and transition Czech economies on market conditions. It was been and still is endeavour these disparities measurably equalize by regional policy state supports structurally depressed and economic weak regions. Regional disparity solving, and with it closely related well-balanced development regions, together constitute long - term process pointing to restraint disequilibrium in mutual relations among economic, environmental and social pillar sustainability and economic growth. For the safeguard development regions is therefore possibly to create conditions for lessening negative regional disparity and utilize inner potential particular regions at respected principles maintainable development Regional disparity and their solving will have out of doubt of principle impact on strategic orientation regional development CR in years 2007 - 2013. Authors in their article deal with identification disparity between eligible regions in CR, analyze development regional policy and her influence over elimination or deepening disparity over the last 15 years. Last but not least think of over strategy hers next development for the next period.

We just estimated twenty million fiscal multipliers

We analyse the role played by data and specification choices as determinants of the size of the fiscal multipliers obtained using structural vector autoregressive models. The results, based on over twenty million fiscal multiplier estimated for European countries, indicate that many seemingly harmless modelling choices have a significant effect on the size and precision of fiscal multiplier estimates. In addition to the structural shock identification strategy, these modelling choices include the definition of spending and taxes, the national accounts system employed, the use of particular interest rates or inflation measures, or whether data are smoothed prior to estimation.Series: Department of Economics Working Paper Serie

Regional E-Government - Some Problems With Data Sharing

The e-government should start with electronic collaboration of governmental departments. Several services, like email, video conference, discussion forums, use of shared documents, etc. should be supported for assisting the efficient and productive collaboration of remote governmental departments. Since the functionality of the provided services is well known, no detailed description of each service phase is provided. The services for citizens are offered through so called governmental portals. The typical use of a governmental portal is to provide information to the citizens and to support several types of citizen–government transactions (e.g. issuing birth certificates, submitting tax forms, conducting electronic payments, etc.). These services open security requirements for an e-Government platform. Their compilation has been based on the security requirements derived for each independent service suite, for the Authentication processes.

Modal Resonant Frequencies and Radiation Quality Factors of Microstrip Antennas

The chosen rectangular and fractal microstrip patch antennas above an infinite ground plane are analyzed by the theory of characteristic modes. The resonant frequencies and radiation Q are evaluated. A novel method by Vandenbosch for rigorous evaluation of the radiation Q is employed for modal currents on a Rao-Wilton-Glisson (RWG) mesh. It is found that the resonant frequency of a rectangular patch antenna with a dominant mode presents quite complicated behaviour including having a minimum at a specific height. Similarly, as predicted from the simple wire model, the radiation Q exhibits a minimum too. It is observed that the presence of out-of-phase currents flowing along the patch antenna leads to a significant increase of the Q factor

Macroeconomic forecasting in the euro area using predictive combinations of DSGE models

We provide a comprehensive assessment of the predictive ability of combinations of Dynamic Stochastic General Equilibrium (DSGE) models for GDP growth, inflation and the interest rate in the euro area. We employ a battery of static and dynamic pooling weights based on Bayesian model averaging principles, prediction pools and dynamic factor representations, and entertain eight different DSGE specifications and four prediction weighting schemes. Our results indicate that exploiting mixtures of DSGE models tends to achieve superior forecasting performance over individual specifications for both point and density forecasts. The largest improvements in the accuracy of GDP growth forecasts are achieved by the prediction pooling technique, while the results for the weighting method based on dynamic factors partly leads to improvements in the quality of inflation and interest rate predictions.Series: Department of Economics Working Paper Serie

Grain morphology reconstruction of crystalline materials from Laue three-dimensional neutron diffraction tomography

The macroscopic properties of advanced engineering and functional materials are highly dependent on their overall grain orientation distribution, size, and morphology. Here we present Laue 3D neutron diffraction tomography providing reconstructions of the grains constituting a coarse-grained polycrystalline material. Reconstructions of the grain morphology of a highly pure Fe cylinder and a Cu cube sample are presented. A total number of 23 and 9 grains from the Fe and Cu samples, respectively, were indexed and reconstructed. Validation of the grain morphological reconstruction is performed by post-mortem EBSD of the Cu specimen

Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation

Funding: This study was supported by the Ministry of Education, Youth, and Sports of the Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18_069/0010054), by the University of Hradec Kralove (Faculty of Science, no. SV2103‐2022), by Charles University, Prague, Czech Republic (project Cooperatio, research area Neurosciences), by the project MH CZ-DRO VFN64165, and by MH CZ - DRO (UHHK, 00179906), by the Ministry of Defence of the Czech Republic (Faculty of Military Health Sciences Hradec Kralove) under the grant entitled the “Long-term organization development plan - Medical Aspects of Weapons of Mass Destruction”, and by the RS MacDonald Charitable Trust and Rosetrees Trust.17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) is a multifunctional mitochondrial enzyme and putative drug target for the treatment of various pathologies including Alzheimer's disease or some types of hormone-dependent cancer. In this study, a series of new benzothiazolylurea-based inhibitors were developed based on the structure-activity relationship (SAR) study of previously published compounds and predictions of their physico-chemical properties. This led to the identification of several submicromolar inhibitors (IC50 ∼0.3 μM), the most potent compounds within the benzothiazolylurea class known to date. The positive interaction with 17β-HSD10 was further confirmed by differential scanning fluorimetry and the best molecules were found to be cell penetrable. In addition, the best compounds weren't found to have additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects. The two most potent inhibitors 9 and 11 were selected for in vivo pharmacokinetic study after intravenous and peroral administration. Although the pharmacokinetic results were not fully conclusive, it seemed that compound 9 was bioavailable after peroral administration and could penetrate into the brain (brain-plasma ratio 0.56).Peer reviewe