An Investigation of Autonomous Vehicle Roundabout Situation

The aim of this paper is to evaluate the impact of connected autonomous behavior in real vehicles on vehicle fuel consumption and emission reductions. Authors provide a preliminary theoretical summary to assess the driving conditions of autonomous vehicles in roundabout, which attempts exploring the impact of driving behavior patterns on fuel consumption and emissions, and including other key factors of autonomous vehicles to reduce fuel consumption and emissions. After summarizing, driving behavior, effective in-vehicle systems, both roundabout physical parameters and vehicle type are all play an important role in energy using. ZalaZONE’s roundabout is selected for preliminary test scenario establishment, which lays a design foundation for further in-depth testing

Non-Markovian coherence dynamics of driven spin boson model: damped quantum beat or large amplitude coherence oscillation

The dynamics of driven spin boson model is studied analytically by means of the perturbation approach based on a unitary transformation. We gave the analytical expression for the population difference and coherence of the two level system. The results show that in the weak driven case, the population difference present damped coherent oscillation (single or double frequency) and the frequencies depend on the initial state. The coherence exhibit damped oscillation with Rabi frequency. When driven field is strong enough, the population difference exhibit undamped large-amplitude coherent oscillation. The results easily return to the two extreme cases without dissipation or without periodic driven.Comment: 15 pages,5 figure

Non-Markovian disentanglement dynamics of two-qubit system

We investigated the disentanglement dynamics of two-qubit system in Non-Markovian approach. We showed that only the couple strength with the environment near to or less than fine-structure constant 1/137, entanglement appear exponential decay for a certain class of two-qubit entangled state. While the coupling between qubit and the environment is much larger, system always appears the sudden-death of entanglement even in the vacuum environment.Comment: 17 pages, 3 figure

Non-markovian dynamics of double quantum dot charge qubit with static bias

The dynamics of charge qubit in double quantum dot coupled to phonons is investigated theoretically. The static bias is considered. By means of the perturbation approach based on unitary transformations, the dynamical tunneling current is obtained explicitly. The biased system displays broken symmetry and a significantly larger coherence-incoherence transition critical point $\alpha _{c}$. We also analyzed the decoherence induced by piezoelectric coupling phonons in detail. The results show that reducing the coupling between system and bath make coherence frequency increase and coherence time prolong. To maintain quantum coherence, applying static bias also is a good means.Comment: 13 pages, 5 figure

Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients

In biochemical systems, intrinsic noise may drive the system switch from one stable state to another. We investigate how kinetic switching between stable states in a bistable network is influenced by dynamic disorder, i.e., fluctuations in the rate coefficients. Using the geometric minimum action method, we first investigate the optimal transition paths and the corresponding minimum actions based on a genetic toggle switch model in which reaction coefficients draw from a discrete probability distribution. For the continuous probability distribution of the rate coefficient, we then consider two models of dynamic disorder in which reaction coefficients undergo different stochastic processes with the same stationary distribution. In one, the kinetic parameters follow a discrete Markov process and in the other they follow continuous Langevin dynamics. We find that regulation of the parameters modulating the dynamic disorder, as has been demonstrated to occur through allosteric control in bistable networks in the immune system, can be crucial in shaping the statistics of optimal transition paths, transition probabilities, and the stationary probability distribution of the network.National Institutes of Health (U.S.) (Grant P01-AI09158)Singapore-MIT Alliance for Research and Technology (SMART

How to use cognitive tools to increase sustainability of elderly people’s mobility?

Aging is a major international trend. The effective and long-term development of activities for the elderly is an important issue. Vehicles must improve the range of activities of older people and increase their life trajectory beyond their age limits. With human participation, autonomous vehicles need to improve driving capabilities to drive safely in traffic scenarios and implement sustainable solutions. We will explore the mobility of aging people when riding in traffic and as pedestrians, with the hope of having sustainable development in terms of convenience and safety for aging people in transportation. The discussion is illustrated in terms of the impact on driving behavior, the functionality of vehicle sensors, and the interaction with traffic road users. This paper helps to illustrate that autonomous driving tasks can benefit aging drivers in terms of driver users, vehicle sensors and systems, and road users when dealing with new or unexpected traffic situations. Identifying cognitive changes and relationships is important better to understand the road environment's cognitive processes and behaviors

Effect of STIM1/2 and of Ceritinib on Platelet Function

Die Veränderung der intrazellulären Ca2+-Konzentration ist an vielen physiologischen Prozessen wie an der Thrombozytenaktivierung und Apoptose beteiligt. Der überwiegende Anteil am Ca2+ Einstrom in aktivierte Thrombozyten beruht wahrscheinlich auf dem von Orai/STIM regulierten, speicherabhängigen Ca2+-Einstrom (SOCE). Die Auswirkungen von STIM1-STIM2 (STIM1/2) sowie von Ceritinib auf den Thrombozyten-Ca2+-Signalweg, Aktivierung und Apoptose wurden in dieser Studie untersucht. STIM1/2 wurde als Ca2+-Sensor beschrieben, der in Orai/STIM-vermittelter SOCE eine entscheidende Rolle spielte. Die vorliegende Studie ergab, dass die Anzahl der Thrombozyten von Stim1/2fl/fl-Mäusen auffallend niedriger als die von Stim1/2fl/fl Pf4-Cre-Mäusen war. Ohne Aktivierung mit Thrombin oder CRP war kein statistisch signifikanter Unterschied der Thrombozytenaggregation zwischen beiden Genotypen erkennbar. Außerdem waren vor der Thrombin- und CRP-Stimulation die Thrombozyten-Degranulation, Orai1, Phosphatidylserin (PS)-Exposition, Integrin-αIIbβ3-Aktivierung, SOCE und intrazelluläre Ca2+-Konzentration ([Ca2+]i) in Thrombozyten von Stim1/2fl/fl-Mäusen und Stim1/2fl/fl Pf4-Cre-Mäusen ähnlich. Die Behandlung von CRP oder Thrombin führte zu einem signifikanten Anstieg der Degranulation, Orai1, PS-Exposition, Integrin-αIIbβ3-Aktivierung, SOCE und [Ca2+] in beiden Genotypen. Alle Effekte waren in Stim1/2fl/fl Pf4-Cre-Plättchen deutlich schwächer als in Stim1/2fl/fl-Plättchen. Diese Daten weisen darauf hin, dass der durch CRP oder Thrombin induzierte Einstrom von Ca2+ in Blutplättchen von mindestens zwei Mechanismen reguliert wird, d.h. STIM1/2-abhängige SOCE und durch einen zweiten Mechanismus, der den Ca2+-Sensor STIM1/2 nicht erfordert. Unsere Daten zeigen, dass das Fehlen von STIM1/2 in Blutplättchen den SOCE tatsächlich aufhebt, aber Thrombin- und CRP-induzierten Ca2+-Einstrom, die Integrinaktivierung, -degranulation und -apoptose nur mäßig mindert. Ceritinib ist bei der Behandlung des ALK-positiven nicht-kleinzelligen Lungenkarzinoms wirksam. Die Substanz löst Apoptose von Tumorzellen aus. Die vorliegende Arbeit hat ergeben, dass thrombozytäres [Ca2+]i in Anwesenheit von sehr hohen Ceritinib-Konzentrationen eine signifikante Abnahme zur Folge hat. Außerdem führte die Exposition der Thrombozyten mit CRP zu einem beachtlichen Anstieg von [Ca2+]i, Orai1-Abundanz, Integrin-αIIbβ3-Aktivierung, Thrombozytengranulation, Zellschrumpfung, Annexin-V-Bindung und ROS-Bildung und –aggregation. Diese Wirkungen von CRP wurden durch Ceritinib gehemmt. Zusammenfassend wirken hohe Konzentrationen an Ceritinib der CRP-induzierten Thrombozytenaktivierung, -apoptose und -aggression entgegen