Quarries, water, stone walls and groves regenerating the identity landscape of Comiso, Italy

The awareness of cultural specificity and geomorphologic and ecological singularities provides the instruments for an evolution capable of transforming the perception of the place and of recovering its memory. The design process is therefore centered in revealing character defining elements that time and indifference have blurred. A plan is then envisioned to create synergy between all these elements in order to capture the mosaic that in space and time has shaped the identity of this place to allow people to reconnect with it. The design restrains itself from a globalized language to adhere to this terrain and these traces through visual suggestions capable of weaving layers of memory to become presentPeer Reviewe

Post-Traumatic Growth and Pregnancy: Exploring the Experiences of Survivors of Child Sexual Abuse

Eighteen women in their second trimester of their first pregnancy who were survivors of childhood sexual abuse, and between the ages of 19 to 48 years old, were interviewed. Each participant was asked a series of questions including their thoughts about becoming a mother and how their lived experiences have changed their perception about raising a baby, their hopes for their baby and how their own beliefs have changed. A thematic analysis was conducted on 18 verbatim transcripts. Transcripts consisted of 120 statements that were coded into 4 major themes. The current research identified four major themes including Change in Perception, Personal Growth, Hope for Child and Spirituality and their subthemes. Results are framed using the Post Traumatic Growth Framework (Tedeschi & Calhoun, 2004). Implications for research and practice are offered. Keywords: posttraumatic growth, trauma, pregnancy, child sexual abus

A range-gated pulsed ultrasonic Doppler flowmeter

http://www.worldcat.org/oclc/814450

The history of small extracellular vesicles and their implication in cancer drug resistance

Small extracellular vesicles (EVs) in the last 20 years are demonstrated to possess promising properties as potential new drug delivery systems, biomarkers, and therapeutic targets. Moreover, EVs are described to be involved in the most important steps of tumor development and progression including drug resistance. The acquired or intrinsic capacity of cancer cells to resist chemotherapies is one of the greatest obstacles to overcome to improve the prognosis of many patients. EVs are involved in this mechanism by exporting the drugs outside the cells and transferring the drug efflux pumps and miRNAs in recipient cells, in turn inducing drug resistance. In this mini-review, the main mechanisms by which EVs are involved in drug resistance are described, giving a rapid and clear overview of the field to the readers

Self-Therapeutic Nanomaterials for Cancer Therapy: A Review

Cancer is a commonly lethal disease that causes many deaths every year around the world. Many strategies have been applied to treat cancer, such as surgery, radiation, and chemotherapy, but all of these therapeutic approaches are limited. Nanotechnology could provide a tremendous platform to boost the efficacy of therapeutic systems from the bench to clinical applications. The current trend of using nanomaterials for therapeutic applications is limited to drug delivery and external stimuli-responsive systems. However, several nanomaterials can reduce the growth of aggressive tumors through their self-therapeutic properties. In this review, we discuss the self-therapeutic nanomaterials that can kill cancer cells without the need for any external stimulation (heat, light, radiation, or a magnetic field) or the loading of any extra therapeutic compounds. These nanomaterials can produce reactive oxygen species, act as deoxygenating agents, or produce free radicals at tumor sites. Self-therapeutic peptide-based and other organic nanomaterials that are used to inhibit multidrug resistance (MDR) proteins, e.g., P-glycoprotein (P-gp), are also discussed. This review discusses the possible mechanisms of action of self-therapeutic nanomaterials for cancer inhibition, highlighting critical and future aspects

Educación Profesional y Demanda del Sector Energético

52 Años Formando Profesionales en el Campo de la Energía y sus Aplicaciones. Facultad de Ingeniería de la Universidad Nacional del Comahue.La Universidad del Neuquén fue creada por la ley provincial N° 414, la que establecía los fundamentos para su creación y funcionamiento, dentro de ella la Facultad de Ingeniería comenzó a funcionar el 1° de abril de 1965 desde entonces es generadora de recurso humano altamente calificado que responde a las demandas del sector energético nacional e internacional

Breast metastasis of primary colon cancer with micrometastasis in the axillary sentinel node: A metastasis that metastasized?

A case of single breast metastasis from colon adenocarcinoma, with omolateral axillary micrometastasis, is reported with a brief review of the pertinent literature. The originality of the oncological concept of metastasis from metastasis, through lymphatics penetration, is discussed in the setting of a rare condition of breast metastasis from a colorectal carcinoma

Clinical and dermoscopic features of porokeratosis of Mibelli

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Nano-imaging of environmental dust in human lung tissue by soft and hard X-ray fluorescence microscopy

It is well recognized that a large number of pulmonary diseases are induced by the effects of inhaled particulates. Anthracosis is defined as an asymptomatic, mild form of pneumoconiosis caused by the accumulation of \u201cblack carbon\u201d in the lungs due to repeated exposure to air pollution or inhalation of smoke or coal dust particles. Since the human population is progressively exposed to an increasing number and doses of anthropogenic micro and nano particles/compounds, there is a pressing urgency to explore toxicological impact arising from these exposures and the molecular mechanisms driving the body defense or possible related diseases. The toxicity mechanisms are clearly related to chemical composition and physical and surface properties of materials. A combination of synchrotron radiation-based (SR-based) nano X-ray fluorescence (XRF) imaging and soft X-ray microscopy was used to chemically characterize environmental particulates (anthracosis) in lung tissues from urban subjects with the aim of better understanding the complex nature of related lungs' deposits. High-resolution XRF analyses performed at ESRF and Elettra synchrotrons allowed discriminating single particles in the heterogeneous aggregates found in the lung tissue. The small particles have variable composition resulting from the different combinations of Ti with O, K and Si, Al and Si, or Zn and Fe with O. Interestingly, simultaneous absorption and phase contrast images showed the particulate morphology and allowed to predict the presence of very dense nanoparticles or high concentration of heavy elements