Digital temperature sensor performance assessment report

Performance assessment data accumulated during exposure of the digital temperature sensor to simulated shuttle flight type environments are presented. The test parameters were specifically designed to check the sensor for its: (1) ability to resolve temperature relative to the design specifications; (2) ability to maintain accuracy after interchanging the temperature probes with each electronics interface assembly; (3) stability (i.e., satisfactory operation and accuracy during and after exposure to flight environments); and (4) repeatability, or its ability to produce the same output on subsequent exposures to the identical stimulus. Equipment list, test descriptions, data summary, and conclusions are included

Downeast Fisheries Trail: Celebrating the Fisheries Heritage of Downeast Maine, Then and Now

Road map of the Downeast Fisheries Trail from Penobscot to Passamaquoddy Bay, connecting historic and active fisheries sites that illustrate the region’s maritime heritage. Marine resources sustain the culture and economy of Downeast Maine. The Downeast Fisheries Trail builds on these local resources to strengthen community life and the experience of visitors. Map includes brief descriptions of 45 businesses, wharves, museums, and parks located along the trail

Safety, immunogenicity, and transplacental antibody transport of conjugated and polysaccharide pneumococcal vaccines administered to pregnant women with HIV: a multicentre randomised controlled trial

Background: Pneumococcus remains an important cause of morbidity in pregnant women with HIV and their infants. We compared the safety and immunogenicity of PCV-10 and PPV-23 with placebo administered in pregnancy. Methods: This double-blind, multicentre, randomised controlled trial was done at eight outpatient clinics in Brazil. Eligible participants were adult women with HIV who were pregnant at a gestational age between 14 weeks and less than 34 weeks and who were taking antiretroviral therapy at study entry. Participants were randomly assigned (1:1:1) to receive either PCV-10, PPV-23, or placebo. Participants and study teams were unaware of treatment allocation. Antibodies against seven vaccine serotypes in PCV-10 and PPV-23 were measured by ELISA. The primary outcomes were maternal and infant safety assessed by the frequency of adverse events of grade 3 or higher; maternal seroresponse (defined as ≥2-fold increase in antibodies from baseline to 28 days after immunisation) against five or more serotypes; and infant seroprotection (defined as anti-pneumococcus antibody concentration of ≥0·35 μg/mL) against five or more serotypes at 8 weeks of life. The study was powered to detect differences of 20% or higher in the primary immunological outcomes between treatment groups. This trial is registered with ClinicalTrials.gov, NCT02717494. Findings: Between April 1, 2016, and Nov 30, 2017, we enrolled 347 pregnant women with HIV, of whom 116 were randomly assigned to the PCV-10 group, 115 to the PPV-23 group, and 116 to the placebo group. One participant in the PCV-10 group did not receive the vaccine and was excluded from subsequent analyses. The frequency of adverse events of grade 3 or higher during the first 4 weeks was similar in the vaccine and placebo groups (3% [90% CI 1–7] for the PCV-10 group, 2% [0–5] for the PPV-23 group, and 3% [1–8] for the placebo group). However, injection site and systemic grade 2 adverse reactions were reported more frequently during the first 4 weeks in the vaccine groups than in the placebo group (14% [9–20] for the PCV-10 group, 7% [4–12] for the PPV-23 group, and 3% [1–7] for the placebo group). The frequency of grade 3 or higher adverse effects was similar across maternal treatment groups (20% [14–27] for the PCV-10 group, 21% [14–28] for the PPV-23 group, and 20% [14–27] for the placebo group). Seroresponses against five or more serotypes were present in 74 (65%) of 114 women in the PCV-10 group, 72 (65%) of 110 women in the PPV-23 group, and none of the 113 women in the placebo group at 4 weeks post vaccination (p<0·0001 for PPV-23 group vs placebo and PCV-10 group vs placebo). Seroresponse differences of 20% or higher in vaccine compared with placebo recipients persisted up to 24 weeks post partum. At birth, 76 (67%) of 113 infants in the PCV-10 group, 62 (57%) of 109 infants in the PPV-23 group, and 19 (17%) of 115 infants in the placebo group had seroprotection against five or more serotypes (p<0·0001 for PPV-23 vs placebo and PCV-10 vs placebo). At 8 weeks, the outcome was met by 20 (19%) of 108 infants in the PCV-10 group, 24 (23%) of 104 infants in the PPV-23 group, and one (1%) of 109 infants in the placebo group (p<0·0001). Although a difference of 20% or higher compared with placebo was observed only in the infants who received PPV-23 at 8 weeks of life, the difference between the two vaccine groups was not appreciable. Interpretation: PCV-10 and PPV-23 were equally safe and immunogenic in pregnant women with HIV and conferred similar levels of seroprotection to their infants. In areas in which childhood PCV administration decreased the circulation of PCV serotypes, PPV-23 administration to pregnant women with HIV might be more advantageous than PCV by virtue of including a broader range of serotypes

The precancer risk of betel quid chewing, tobacco use and alcohol consumption in oral leukoplakia and oral submucous fibrosis in southern Taiwan

In areas where the practise of betel quid chewing is widespread and the chewers also often smoke and drink alcohol, the relation between oral precancerous lesion and condition to the three habits is probably complex. To explore such association and their attributable effect on oral leukoplakia (OL) and oral submucous fibrosis (OSF), a gender–age-matched case–control study was conducted at Kaohsiung, southern Taiwan. This study included 219 patients with newly diagnosed and histologically confirmed OL or OSF, and 876 randomly selected community controls. All information was collected by a structured questionnaire through in-person interviews. A preponderance of younger patients had OSF, while a predominance of older patients had OL. Betel quid chewing was strongly associated with both these oral diseases, the attributable fraction of OL being 73.2% and of OSF 85.4%. While the heterogeneity in risk for areca nut chewing across the two diseases was not apparent, betel quid chewing patients with OSF experienced a higher risk at each exposure level of chewing duration, quantity and cumulative measure than those who had OL. Alcohol intake did not appear to be a risk factor. However, cigarette smoking had a significant contribution to the risk of OL, and modified the effect of chewing based on an additive interaction model. For the two oral premalignant diseases combined, 86.5% was attributable to chewing and smoking. Our results suggested that, although betel quid chewing was a major cause for both OL and OSF, its effect might be difference between the two diseases. Cigarette smoking has a modifying effect in the development of oral leukoplakia

The Loff Concept: Offshore Helicopter Flight Following Using Loran-C

LORAN-C Flight Following (LOFF) is a field test program which uses an existing radionavigation system and communications network, and current computer/display technology, to allow air traffic controllers at the Houston Air Route Traffic Control Center (ARTCC) to follow the flight progress of helicopter traffic to and from oil platforms in the Gulf of Mexico. Helicopters which carry personnel and equipment to the oil platforms fly at altitudes below and beyond the line-of-sight coverage of communications (VHF voice), surveillance (radar), and navigation (VOR/DME) systems, hence the need for flight following. The ultimate goals of the LOFF program are to enhance the safety of helicopter operations in offshore areas, and to improve the efficiency of flight time through the development of a flexible route structure

Touch Hetchy

Touch Hetchy is a touch interactive educational application designed to leverage the ultra HD screen display of the Pro Multitouch Table. John Muir’s historical images are brought to life through super HD quality. Through trying to match up the historical images to a location on a map of the valley, users will learn about John Muir and how the Hetch Hetchy Valley looked before the area was dammed. Special thanks to the University of the Pacific Library, and the Holt-Atherton Special Collections

Touch Hetchy

Touch Hetchy is a touch interactive educational application designed to leverage the ultra HD screen display of the Pro Multitouch Table. John Muir’s historical images are brought to life through super HD quality. Through trying to match up the historical images to a location on a map of the valley, users will learn about John Muir and how the Hetch Hetchy Valley looked before the area was dammed. Special thanks to the University of the Pacific Library, and the Holt-Atherton Special Collections