Archaeometric characterization of prehistoric pottery from Baħrija, Malta

The end of prehistory in the Maltese archipelago is characterized by the production of a problematic class of pottery, until now attested just at the site of Baħrija, on the western coast of Malta. Such a production represents a break with the tradition in terms of repertoire of shapes, style and technology and it has been interpreted as the result of contact between locals and foreign immigrants. The recent overall reappraisal of the unpublished ceramic assemblage collected during the excavations carried out at Baħrija, represents a unique opportunity to focus on the technological aspects of the production, trying to shed light on the issue of the break with the tradition and the impact of external influxes. Petrographic analysis on thin sections and chemical analyses via X-ray fluorescence spectroscopy (XRF) and laser ablation-inductively coupled plasma mass spectroscopy (LA-ICP-MS) have been carried out to characterize the Baħrija pottery production in order to interpret from a different angle the issue of the possible arrival of newcomers and establishment of a foreign enclave in Malta, which until now has been hypothesized only on the basis of the sudden emergence of the Baħrija pottery

Italo-Mycenaean and other Aegean-influenced pottery in Late Bronze Age Italy: the case for regional production

Decorated Italo-Mycenaean (IM) pottery, a high-status class found and made over three centuries from the Italian Late Middle Bronze Age onwards, was the subject of a large archaeological and archaeometric enquiry published by the present authors in 2014. The present paper focuses on identifying IM’s centres of production. The results of chemical analysis of IM using mainly ICP-ES make a strong case for regional production, irrespective of findspots in several parts of Italy. This accords well with the relative stylistic individuality of IM observed among the finds of IM across many parts of Italy, suggesting that IM is a powerful archaeological indicator of the way local communities were constructing and negotiating their identities at this crucial time of social and economic change at the end of the Bronze Age. A picture of more dispersed intra-regional production emerges from the combined chemical and petrographic analysis of two other pottery classes displaying Aegean influence: wheel-made Grey ware and decorated Final Bronze Age/Early Iron Age (FBA/EIA) pottery from sites in present-day Apulia and from Broglio di Trebisacce in Calabria. Potters manufacturing the former applied their knowledge of the wheel and kiln firing to handmade impasto shapes which were largely shared by local communities within a region. The results obtained for the latter reflect demands of the new elites of the emerging FBA/EIA in southern Italy to create symbols expressing a new cultural identity: this pottery’s style, especially of Protogeometric, was uniform but its production was localised

Obsidian from the Bronze Age Village of San Vincenzo, Stromboli, Aeolian Islands: A Preliminary Investigation

We present the preliminary results of the ongoing investigation of the obsidian from the Bronze Age village of San Vincenzo, Stromboli, Aeolian Islands, for the purpose of providing technological and typological characterization, and also provenance of the raw material, the latter with non-destructive p-XRF. Regarding provenance, the source of the raw material is likely to be neighbouring Lipari. It was transported to Stromboli and used mostly in a highly opportunistic manner and for the production of blade(let), non-bladelike tools (mainly scrapers) and micro bladelets. The obsidian distribution around the site shows concentration in both domestic and production areas

Pediatric Multisystem Syndrome Associated with SARS-CoV-2 (MIS-C): The Interplay of Oxidative Stress and Inflammation

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (MIS-C) is characterized by persistent fever and evidence of single or multiorgan dysfunction, and laboratory evidence of inflammation, elevated neutrophils, reduced lymphocytes, and low albumin. The pathophysiological mechanisms of MIS-C are still unknown. Proinflammatory mediators, including reactive oxygen species and decreased antioxidant enzymes, seems to play a central role. Virus entry activates NOXs and inhibits Nrf-2 antioxidant response inducing free radicals. The biological functions of nonphagocytic NOXs are still under study and appear to include: defense of epithelia, intracellular signaling mechanisms for growth regulation and cell differentiation, and post-translational modifications of proteins. This educational review has the aim of analyzing the newest evidence on the role of oxidative stress (OS) in MIS-C. Only by relating inflammatory mediators to OS evaluation in children following SARS-CoV-2 infection will it be possible to achieve a better understanding of these mechanisms and to reduce long-term morbidity. The link between inflammation and OS is key to developing effective prevention strategies with antioxidants to protect children

p-XRF analysis of multi-period Impasto and Cooking Pot wares from the excavations at Stromboli-San Vincenzo, Aeolian Islands, Italy

This exploratory study focuses on the elemental analysis by p-XRF (portable X-Ray Fluorescence Analyser) of 62 samples of coarse wares, consisting of Bronze Age handmade burnished ware, so-called Impasto, and of Cooking ware (dated from the Roman period to Modern times). All wares originate from the site of San Vincenzo, Stromboli, and Aeolian Islands. The question addressed here is whether it is possible to differentiate between local (Aeolian) and imported (non-Aeolian) fabrics with the use of the p-XRF; 42 of the 62 samples were also subjected to petrographic analysis as a way of testing our hypothesis. Our results show that p-XRF analysis can clearly assist in distinguishing between Aeolian vs. non-Aeolian wares. Analyses can take place in the field and large quantities of sherds can be processed as a result. We suggest that no further demands should be made of the technique in providing answers to more detailed provenance questions. This is because finer separation in subgroups (as achieved recently by combined petrographic and EPMA analysis on select samples) is not possible given the nature of coarse pottery and the limitations of the technique in measuring key light elements (Na, Mg). Furthermore, for some elements (e.g Cr) accuracy is below acceptable levels in which case results for these particular elements are considered semi-quantitative

Exposure to different light intensities affects emission of volatiles and accumulations of both pigments and phenolics in Azolla filiculoides

Many agronomic trials demonstrated the nitrogen‐fixing ability of the ferns Azolla spp. and its obligate cyanobiont Trichormus azollae. In this study, we have screened the emission of volatile organic compounds (VOCs) and analyzed pigments (chlorophylls, carotenoids) as well as phenolic compounds in Azolla filiculoides–T. azollae symbionts exposed to different light intensities. Our results revealed VOC emission mainly comprising isoprene and methanol (~82% and ~13% of the overall blend, respectively). In particular, by dissecting VOC emission from A. filiculoides and T. azollae, we found that the cyanobacterium does not emit isoprene, whereas it relevantly contributes to the methanol flux. Enhanced isoprene emission capacity (15.95 ± 2.95 nmol m(−2) s(−1)), along with increased content of both phenolic compounds and carotenoids, was measured in A. filiculoides grown for long‐term under high (700 μmol m(−2) s(−1)) rather than medium (400 μmol m(−2) s(−1)) and low (100 μmol m(−2) s(−1)) light intensity. Moreover, light‐responses of chlorophyll fluorescence demonstrated that A. filiculoides was able to acclimate to high growth light. However, exposure of A. filiculoides from low (100 μmol m(−2) s(−1)) to very high light (1000 μmol m(−2) s(−1)) did not affect, in the short term, photosynthesis, but slightly decreased isoprene emission and leaf pigment content whereas, at the same time, dramatically raised the accumulation of phenolic compounds (i.e. deoxyanthocyanidins and phlobaphenes). Our results highlight a coordinated photoprotection mechanism consisting of isoprene emission and phenolic compounds accumulation employed by A. filiculoides to cope with increasing light intensities

New findings on presentation and outcome of patients with adrenocortical cancer: results from a national cohort study

Context: Due to the rarity of adrenocortical cancer (ACC), only a few population-based studies are available and they reported limited details in the characterization of patients and their treatment. Objective: To describe in a nation-wide cohort the presentation of ACC patients, treatment strategies and potential prognostic factors. Methods: Retrospective analysis of 512 ACC patients, diagnosed in twelve referral centers in Italy from January 1990 to June 2018. Results: ACC diagnosed as incidentalomas accounted for overall 38.1% of cases, with a frequency that increases with age and with less aggressive pathological features than symptomatic tumors. Women (60.2%) were younger than men, had smaller tumors, which more frequently secreted hormones. Surgery was mainly done with an open approach (72%), and after surgical resection, 62.7% of patients started adjuvant mitotane therapy. Recurrence after tumor resection occurred in 56.2% of patients. In patients with localized disease, cortisol secretion, ENSAT stage III, Ki67% and Weiss score were associated with an increased risk of recurrence, while margin-free resection, open surgery and adjuvant mitotane treatment were associated with reduced risk. Death occurred in 38.1% of patients and recurrence-free survival (RFS) predicted overall survival (OS). In localized disease, age, cortisol secretion, Ki67%, ENSAT stage III, and recurrence were associated with increased risk of mortality.ACCs presenting as adrenal incidentalomas showed prolonged RFS and OS. Conclusions: Our study shows that ACC is a sex-related disease and demonstrates that an incidental presentation is associated with a better outcome. Given the correlation between RFS and OS, RFS may be used as a surrogate end-point in clinical studies