Quality of life assessment and its spatial correlation in impoverished districts and counties: A case study of Guizhou Province

China’s rapid urbanization has greatly boosted the quality of life of its traditionally impoverished regions. Research into the spatial distribution characteristics, evolution and spatial correlation of the quality of life in impoverished regions can help illuminate the experience of successful development and construct a knowledge base for authorities to devise development strategies. This study focuses its attention on the historically impoverished districts and counties (which are designated as parallel administrative units in China) of Guizhou Province in southwestern China. Extensively citing official statistics on districts and counties released by China’s National Bureau of Statistics and local governments, it assesses the quality of life of those places in the 3 years of 2000, 2010, and 2020 from the four dimensions of economy, society, culture, and environment. The aim is to illustrate the distribution characteristics and the evolution of quality of life in Guizhou’s historically impoverished districts and counties. In order to understand the characteristics of spatial clustering as well as the patterns of evolution of the quality of life of Guizhou’s impoverished districts and counties, the study incorporates spatial autocorrelation analysis into a spatio-temporal analysis of local quality of life. It could presumably help enrich the knowledge base that local authorities draw on to formulate development strategies that are scientific and adapted to local conditions. The study found that while the overall quality of life in all the impoverished districts and counties of Guizhou Province has improved, large gaps in quality of life between eastern and western regions of the province persisted. In addition, the driving force behind the evolution in the overall quality of life of those places changed with time, as did the characteristics of the spatial aggregation in quality of life

Developing a class of dual atom materials for multifunctional catalytic reactions

Dual atom catalysts, bridging single atom and metal/alloy nanoparticle catalysts, offer more opportunities to enhance the kinetics and multifunctional performance of oxygen reduction/evolution and hydrogen evolution reactions. However, the rational design of efficient multifunctional dual atom catalysts remains a blind area and is challenging. In this study, we achieved controllable regulation from Co nanoparticles to CoN4 single atoms to Co2N5 dual atoms using an atomization and sintering strategy via an N-stripping and thermal-migrating process. More importantly, this strategy could be extended to the fabrication of 22 distinct dual atom catalysts. In particular, the Co2N5 dual atom with tailored spin states could achieve ideally balanced adsorption/desorption of intermediates, thus realizing superior multifunctional activity. In addition, it endows Zn-air batteries with long-term stability for 800 h, allows water splitting to continuously operate for 1000 h, and can enable solar-powered water splitting systems with uninterrupted large-scale hydrogen production throughout day and night. This universal and scalable strategy provides opportunities for the controlled design of efficient multifunctional dual atom catalysts in energy conversion technologies

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth.

Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double strands, as a new binding protein of the COX-2 gene promoter. Overexpression of Ku80 up-regulated COX-2 promoter activation and COX-2 expression in lung cancer cells. Silencing of Ku80 by siRNA down-regulated COX-2 expression and inhibited tumor cell growth in vitro and in a xenograft mouse model. Ku80 knockdown suppressed phosphorylation of ERK, resulting in an inactivation of the MAPK pathway. Moreover, CBP, a transcription co-activator, interacted with and acetylated Ku80 to co-regulate the activation of COX-2 promoter. Overexpression of CBP increased Ku80 acetylation, thereby promoting COX-2 expression and cell growth. Suppression of CBP by a CBP-specific inhibitor or siRNA inhibited COX-2 expression as well as tumor cell growth. Tissue microarray immunohistochemical analysis of lung adenocarcinomas revealed a strong positive correlation between levels of Ku80 and COX-2 and clinicopathologic variables. Overexpression of Ku80 was associated with poor prognosis in patients with lung cancers. We conclude that Ku80 promotes COX-2 expression and tumor growth and is a potential therapeutic target in lung cancer

Exploring the Relationship between Urban Street Spatial Patterns and Street Vitality: A Case Study of Guiyang, China

Understanding how street spatial patterns are related to street vitality is conducive to enhancing effective urban and street design. Such analysis is facilitated by big data technology as it enables more accurate methods. This study cites data from street view imagery (SVI) and points of interest (POI) to assess street vitality strength after the classification of street spatial and vitality types to explore the relationship between street spatial patterns and street vitality with a further discussion on the layout features of street vitality and its strength in various street spatial patterns. First, street spatial patterns are quantified based on SVI, which are further classified using principal component analysis and cluster analysis; POI data are then introduced to identify street vitality patterns and layout, and the strength of street vitality is evaluated using spatial overlay analysis. Finally, relevance analysis is explored to cast light on the relationship between street vitality layout and street spatial patterns by overlaying street spatial pattern, street vitality types, and street vitality strength in the grid cells. This paper takes the urban area of Guiyang, China, as an example and the analysis shows that a pattern is discovered in Guiyang regarding the layout of street vitality types and vitality strengths across different street spatial patterns; compact street spaces should be prioritized in designing street space renovation; and cultural leisure vitality is most adaptive to street spatial patterns. Based on big data and using grids to understand the intrinsic relationship between street spatial patterns and the type and strength of street vitality, this paper brings more options to urban street studies in terms of perspective and methodology

Fast Fourier transform method for determining velocities of ultrasonic Rayleigh waves using a comb transducer

A convenient, accurate and precise method is proposed to determine velocities of ultrasonic Rayleigh waves in different materials by extracting central frequencies of signals, which are measured by a comb transducer and converted to the frequency domain using the fast Fourier transformation (FFT). The velocities can be calculated as cr = fl, where f is the central frequency of the wave signal and l is the teeth spacing or period of the comb transducer. The experimental measurements are easy to do, as long as the Rayleigh wave reflected from the standard reflectors are measured using one comb transducer, without knowing the wave propagation distances and times. Results show that the proposed technique has a high level of precision, as the central frequencies are very stable. The same comb transducer is used to measure the Rayleigh wave velocities in different materials where the velocities vary from 2100 m/s to 3400 m/s. Comparison of the experimental results with those measured using the time-of-flight method showed a high level of accuracy - all relative errors were found to be less than 1%.National Natural Science Foundation of China24 month embargo; available online: 30 April 2022This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Informal Community Growing Characteristics and the Satisfac-tion of Concerned Residents in Mountainous Urban Areas of Southwest China

Due to the mountainous terrain in the urban areas of southwest China, there are a large number of barren slopes in the community unsuitable for construction. These areas, alongside other unusable space which is often cultivated by residents to create informal community vegetable gardens and fruit growing areas, have become a “gray area” for urban management. This paper attempts to study the characteristics of informal community growing, the composition of growers, the motivation for growing, and the satisfaction of residents in urban areas in mountainous southwest China to explore its relative value. The sample area for the study was Yongchuan, Chongqing, Southwest China. Through a field survey, a semantic differential questionnaire, and data analysis, we found that: (1) growers use traditional cultivation methods to grow diverse fruits and vegetables according to the size of the slope, and the scale is so large that it serves as a local food supply; (2) growers are mainly vulnerable groups who use the land for economic gain and green food acquisition; and (3) growers and non-growers are more satisfied with the food supply and economic benefits generated by cultivation, while they are dissatisfied with the environmental and social benefits and the planting process. Satisfaction also varies with age, occupation, income, education, household registration, and farming experience. Based on the findings, this paper presents recommendations for the future transformation and development of informal community cultivation in mountainous areas. The study has implications for the construction of community gardens and urban agriculture in the mountains

Genome architecture and tetrasomic inheritance of autotetraploid potato

Potato (Solanum tuberosum) is the most consumed non-cereal food crop. Most commercial potato cultivars are autotetraploids with highly heterozygous genomes, severely hampering genetic analyses and improvement. By leveraging the state-of-the-art sequencing technologies and polyploid graph binning, we achieved a chromosome-scale, haplotype-resolved genome assembly of a cultivated potato, Cooperation-88 (C88). Intra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome. We identified haplotype-specific pericentromeres on chromosomes, suggesting a distinct evolutionary trajectory of potato homologous centromeres. Furthermore, we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny, a feature of autopolyploid inheritance. By distinguishing maternal and paternal haplotype sets in C88, we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations, which were masked in the heterozygous condition by two parents. This study provides insights into the genomic architecture of autopolyploids and will guide their breeding

Quantum Chemistry Calculation-Aided Structural Optimization of Combretastatin A‑4-like Tubulin Polymerization Inhibitors: Improved Stability and Biological Activity

A potent combretastatin A-4 (CA-4) like tubulin polymerization inhibitor <b>22b</b> was found with strong antitumor activity previously. However, it easily undergoes <i>cis–trans</i> isomerization under natural light, and the resulting decrease in activity limits its further applications. In this study, we used quantum chemistry calculations to explore the molecular basis of its instability. Aided by the calculations, two rounds of structural optimization of <b>22b</b> were conducted. Accelerated quantitative light stability testing confirmed that the stability of these designed compounds was significantly improved as predicted. Among them, compounds <b>1</b> and <b>3b</b> displayed more potent inhibitory activity on tumor cell growth than <b>22b</b>. In addition, the potent <i>in vivo</i> antitumor activity of compound <b>1</b> was confirmed. Quantum chemistry calculations were used in the optimization of stilbene-like molecules, providing new insight into stilbenoid optimization and important implications for the future development of novel CA-4-like tubulin polymerization inhibitors