18 research outputs found

    Greenberg algebras and ramified Witt vectors

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    Let  be a complete discrete valuation ring of mixed characteristic and with finite residue field k. We study a natural morphism r: R_O→W_{O,k} between the Greenberg algebra of O and the special fiber of the scheme of ramified Witt vectors over O. It is a universal homeomorphism with proinfinitesimal kernel that can be explicitly described in some cases

    Unique diagnostic signatures of concussion in the saliva of male athletes: the Study of Concussion in Rugby Union through MicroRNAs (SCRUM)

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    Funder: Medical Research Council; FundRef: http://dx.doi.org/10.13039/501100000265Funder: National Institute for Health Research; FundRef: http://dx.doi.org/10.13039/501100000272Funder: Marker DiagnosticsFunder: Rugby Football UnionFunder: Midland Neuroscience Teaching and Research FundObjective: To investigate the role of salivary small non-coding RNAs (sncRNAs) in the diagnosis of sport-related concussion. Methods: Saliva was obtained from male professional players in the top two tiers of England’s elite rugby union competition across two seasons (2017–2019). Samples were collected preseason from 1028 players, and during standardised head injury assessments (HIAs) at three time points (in-game, post-game, and 36–48 hours post-game) from 156 of these. Samples were also collected from controls (102 uninjured players and 66 players sustaining a musculoskeletal injury). Diagnostic sncRNAs were identified with next generation sequencing and validated using quantitative PCR in 702 samples. A predictive logistic regression model was built on 2017–2018 data (training dataset) and prospectively validated the following season (test dataset). Results: The HIA process confirmed concussion in 106 players (HIA+) and excluded this in 50 (HIA−). 32 sncRNAs were significantly differentially expressed across these two groups, with let-7f-5p showing the highest area under the curve (AUC) at 36–48 hours. Additionally, a combined panel of 14 sncRNAs (let-7a-5p, miR-143-3p, miR-103a-3p, miR-34b-3p, RNU6-7, RNU6-45, Snora57, snoU13.120, tRNA18Arg-CCT, U6-168, U6-428, U6-1249, Uco22cjg1,YRNA_255) could differentiate concussed subjects from all other groups, including players who were HIA− and controls, immediately after the game (AUC 0.91, 95% CI 0.81 to 1) and 36–48 hours later (AUC 0.94, 95% CI 0.86 to 1). When prospectively tested, the panel confirmed high predictive accuracy (AUC 0.96, 95% CI 0.92 to 1 post-game and AUC 0.93, 95% CI 0.86 to 1 at 36–48 hours). Conclusions: SCRUM, a large prospective observational study of non-invasive concussion biomarkers, has identified unique signatures of concussion in saliva of male athletes diagnosed with concussion

    Disegnando somme esponenziali

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    L'articolo rappresenta un'unit\ue0 didattica per avvicinare i ragazzi della scuola superiore alla geometria del piano complesso. Attraverso alcuni esempi di crescente complessit\ue0 si mostra come disegnare poligonali associate a somme esponenziali

    Catalytic hydrogenation of propene over polymer supported rhodium complexes

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    Hydrogenation of propene and other substrates has been studied in flow and batch reactors using various rhodium catalysts. The results show that in some cases rhodium metal is probably formed, but only if solvent is present. A possible explanation is given. © 1978

    Gender-related differences concerning anger expression and interpersonal relationships in a sample of overweight/obese subjects

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    Objectives: Obesity and overweight are relevant public health issues. They are frequently associated with increased disability, enhanced morbidity and mortality and are often comorbid with several psychological/psychiatric conditions. The aim of the present study was to explore gender-related differences concerning anger expression and interpersonal relationships in a sample of overweight/obese subjects. Materials and Methods: The convenience sample consisted of 40 overweight/obese subjects (18 women, 22 men) who were administered self-report questionnaires to assess eating disorders (EDI-2), anger levels (STAXI) and self/other perception as a measure of interpersonal relationships (9AP). Results: Women had higher scores on the EDI-2 subscales of Bulimia (7.22 vs. 2.20: z=7.61; p<.001), Body Dissatisfaction (15.56 vs. 12.14: z=1.88; p=.03), Interoceptive Awareness (9.89 vs. 5.28: z=4.06; p<.001), Ineffectiveness (11.00 vs 5.22: z=4.91; p <.001) and Perfectionism (6.33 vs. 3.26: z=4.13; p<.001) compared to norms. The overweight/obese men departed from the norms on fewer subscales. Both women and men tended to turn feelings of anger in toward themselves, suppressing their anger. Also, women obtained lower scores for Self Empathy (29.06 vs. 40.15: z = - 2.30; p =.01) and Other Empathy (16.44 vs. 27.10: z =- 2.00; p=.02) whereas overweight/ obese men obtained lower scores for Other Empathy (20.77 vs. 28.47: z=-2.00; p=.02). Conclusions: Overweight/obese subjects have a tendency to turn feelings of anger inward on to themselves together with impaired interpersonal relationships, especially in women. An adequate clinical assessment in all obese individuals trying to identify the contribution of psychological factors to the perceived distress is critical. © Società Editrice Universo (SEU)

    Funzioni theta ed equazioni differenziali

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