572 research outputs found

    Work environments for employee creativity

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    Innovative organisations need creative employees who generate new ideas for product or process innovation. This paper presents a conceptual framework for the effect of personal, social-organisational and physical factors on employee creativity. Based on this framework an instrument to analyse the extent to which the work environment enhances creativity is developed. We apply this instrument to a sample of 409 employees and find support for the hypothesis that a creative work environment enhances creative performance. We illustrate how the instrument can be used in companies to select and implement improvements

    Semiconductor manufacturing simulation design and analysis with limited data

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    This paper discusses simulation design and analysis for Silicon Carbide (SiC) manufacturing operations management at New York Power Electronics Manufacturing Consortium (PEMC) facility. Prior work has addressed the development of manufacturing system simulation as the decision support to solve the strategic equipment portfolio selection problem for the SiC fab design [1]. As we move into the phase of collecting data from the equipment purchased for the PEMC facility, we discuss how to redesign our manufacturing simulations and analyze their outputs to overcome the challenges that naturally arise in the presence of limited fab data. We conclude with insights on how an approach aimed to reflect learning from data can enable our discrete-event stochastic simulation to accurately estimate the performance measures for SiC manufacturing at the PEMC facility

    Tracking turtles in the past:Zooarchaeological evidence for human-turtle interactions in the ancient Eastern Mediterranean

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    Turtles are important barometers of human impact on marine biodiversity. Very little, however, is known about the deep history of human-turtle interactions and whether this is reflected in the present-day vulnerability of Mediterranean turtle populations. Here, the authors critically assess the zooarchaeological evidence for the nature and intensity of past human interactions with green, loggerhead turtles and Nile soft-shell turtles in the Eastern Mediterranean. Species and sex identifications, estimates of relative abundance, and size reconstructions at five coastal archaeological sites demonstrate the variety in interactions, from turtle capture to processing, and allow informative comparisons with present-day distributions of these species across the region

    Scalars, Vectors and Tensors from Metric-Affine Gravity

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    The metric-affine gravity provides a useful framework for analyzing gravitational dynamics since it treats metric tensor and affine connection as fundamentally independent variables. In this work, we show that, a metric-affine gravity theory composed of the invariants formed from non-metricity, torsion and curvature tensors can be decomposed into a theory of scalar, vector and tensor fields. These fields are natural candidates for the ones needed by various cosmological and other phenomena. Indeed, we show that the model accommodates TeVeS gravity (relativistic modified gravity theory), vector inflation, and aether-like models. Detailed analyses of these and other phenomena can lead to a standard metric-affine gravity model encoding scalars, vectors and tensors.Comment: 13 p

    Subtle pH differences trigger single residue motions for moderating conformations of calmodulin

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    This study reveals the essence of ligand recognition mechanisms by which calmodulin (CaM) controls a variety of Ca2+ signaling processes. We study eight forms of calcium-loaded CaM each with distinct conformational states. Reducing the structure to two degrees of freedom conveniently describes main features of the conformational changes of CaM via simultaneous twist-bend motions of the two lobes. We utilize perturbation-response scanning (PRS) technique, coupled with molecular dynamics simulations. PRS is based on linear response theory, comprising sequential application of directed forces on selected residues followed by recording the resulting protein coordinates. We analyze directional preferences of the perturbations and resulting conformational changes. Manipulation of a single residue reproduces the structural change more effectively than that of single/pairs/triplets of collective modes of motion. Our findings also give information on how the flexible linker acts as a transducer of binding information to distant parts of the protein. Furthermore, by perturbing residue E31 located in one of the EF hand motifs in a specific direction, it is possible to induce conformational change relevant to five target structures. Independently, using four different pKa calculation strategies, we find this particular residue to be the charged residue (out of a total of 52), whose ionization state is most sensitive to subtle pH variations in the physiological range. It is plausible that at relatively low pH, CaM structure is less flexible. By gaining charged states at specific sites at a pH value around 7, such as E31 found in the present study, local conformational changes in the protein will lead to shifts in the energy landscape, paving the way to other conformational states. These findings are in accordance with Fluorescence Resonance Energy Transfer (FRET) measured shifts in conformational distributions towards more compact forms with decreased pH. They also corroborate mutational studies and proteolysis results which point to the significant role of E31 in CaM dynamics

    Impacts of interdisciplinary engineering education:A systematic review of the literature

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    Potential applications of biomolecular archaeology to the ecohistory of sea turtles and groupers in Levant coastal antiquity

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    Humans have been exploiting marine resources along the Levantine coast for millennia. Advances in biomolecular archaeology present novel opportunities to understand the exploitation of these taxa in antiquity. We discuss the potential insights generated by applying collagen peptide fingerprinting, ancient DNA analysis, and stable isotope analysis to groupers (Serranidae) and sea turtles (Chelonia mydas and Caretta caretta) in the Levant. When combined with traditional zooarchaeological techniques, biomolecular archaeology offers utility to further investigate human impacts on marine ecosystems

    Measurement of the Target-Normal Single-Spin Asymmetry in Deep-Inelastic Scattering from the Reaction ³He↑(e,e\u27)X

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    We report the first measurement of the target-normal single-spin asymmetry in deep-inelastic scattering from the inclusive reaction 3He↑(e, e\u27)X on a polarized 3He gas target. Assuming time-reversal invariance, this asymmetry is strictly zero in the Born approximation but can be nonzero if two-photon-exchange contributions are included. The experiment, conducted at Jefferson Lab using a 5.89 GeV electron beam, covers a range of 1.7 \u3c W \u3c 2.9 GeV, 1.0 \u3c Q2 \u3c 4.0 GeV2 and 0.16 \u3c x \u3c 0.65. Neutron asymmetries were extracted using the effective nucleon polarization and measured proton-to-3He cross-section ratios. The measured neutron asymmetries are negative with an average value of (-1.09 ± 0.38) x 10-2for invariant mass W \u3e 2 GeV, which is nonzero at the 2.89σ level. Our measured asymmetry agrees both in sign and magnitude with a two-photon-exchange model prediction that uses input from the Sivers transverse momentum distribution obtained from semi-inclusive deep-inelastic scattering

    A review of phytic acid sources, obtention, and applications

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    Phytic acid (PA), extracted from oilseeds, legumes, cereals, nuts, and pollen by acid solutions under heating and/or stirring and then purified, has shown beneficial health and physiological effects due to its pronounced antioxidant activity and ability to chelate Fe3+ ions. Publications on PA have increased, especially the ones reporting its effect on disease prevention and treatment. Moreover, recent studies have suggested the PA efficacy as a foodborne pathogens inhibitor. Therefore, due to its countless proven properties, phytic acid has gained greater attention than its common classification as just an antinutrient. Past and current studies have been reviewed to provide an overview on PA structure, sources, biosynthesis, extraction, purification, and applications.The authors would like to thank the financial support of CNPq, CAPES (finance code 001) and Fundação Araucária (project code 3462014). Joana S. Amaral is thankful to the Foundation for Science and Technology (FCT, Portugal) for their financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020).This work was supported by the CNPq; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior [001]; Fundação Araucária [3462014]; Foundation for Science and Technology [UIDB/00690/2020].info:eu-repo/semantics/publishedVersio
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