16 research outputs found
THE EFFECT OF CHRONIC DIAZEPAM ADMINISTRATION ON LIPID PEROXIDATION AND CA 2+ -ATPASE ACTIVITY IN RAT LIVER
Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a
decrease in glutathione (GSH) content. DZP also markedly lowered Ca
2+
ATPase activity. Treatment with
Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased
lipid peroxidation together with alteration in Ca
2+
-ATPase activity may play a role in DZP induced hepat-
ic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxi-
city