Modeling flow through non linear coarse porous media by a finite difference scheme, with application to rockfill dams overtopping

La circulación del agua a través de medios porosos gruesos, como la escollera, la grava o incluso la arena de mayor tamaño, tiene la particularidad de exhibir una relación no lineal entre el gradiente hidráulico y la velocidad de filtración. Uno de los problemas de ingeniería en que se observa esto es cuando se produce un sobrevertido en una presa de escollera y el agua, pasando sobre su coronación, se infiltra en el espaldón y circula por su interior. La modelación numérica del problema se resuelve aquí mediante un esquema de diferencias finitas, que se implementa en el código MNLEE.RDS para su aplicación al sobrevertido en presas de escollera. Además, se proporciona un procedimiento para resolver el acoplamiento del movimiento del agua en lámina libre sobre el talud de la presa y de filtración por el interior del espaldón, mediante la introducción del concepto «ley de intercambio de caudales».Flow through coarse porous media, as rockfill, gravel or sand of big size, exhibit a non linear relation between hydraulic gradient and seepage velocity. This behavior is observed when water flows over the crest of a rockfill dam, seeps into the downstream shoulder and moves through the rockfill voids. A finite difference scheme is used here to solve this problem through numerical modeling. It is implemented in the code MNLEE.RDS for solving dam overtopping problems. In addition, a procedure is provided to solve the coupled problem of flow over and through the rockfill dam. For that purpose, the concept of «law of flow exchange»is introduced.Peer Reviewe

Entropy Production in the Inflationary Epoch Using the Gouy-Stodola Theorem

In this work, we use the Gouy-Stodola theorem to calculate the entropy production rate in the inflationary epoch of the universe. This theorem allows us the simple calculation of entropy and entropy production rate occasioned by the decaying of the inflaton scalar field. Both the entropy and entropy production rate achieve large values, agreeing with the expected values present in the literature

Preheating in Quintessential Inflation

We perform a numerical study of the preheating mechanism of particle production in models of quintessential inflation and compare it with the usual gravitational production mechanism. We find that even for a very small coupling between the inflaton field and a massless scalar field, g > 10^{-9}, preheating dominates over gravitational particle production. Reheating temperatures in the range 10^{-2} GeV < T_{rh} < 10^{15} GeV can be easily obtained

Análise do aproveitamento econômico do resíduo florestal.

Através de dados de pesquisas existentes sobre o conteúdo de nutrientes em resíduos florestais de Eucalyptus e Pinus, investigou-se a vantagem econômica da utilização dos resíduos, como energia ou como reciclagem de nutrientes no solo. Os resultados mostraram que o emprego dos resíduos florestais como energia se apresenta mais econômico, compensando, inclusive, a reposição de nutrientes através da adubação química. O baixo valor da equivalência da fitomassa em nutrientes, em relação ao de sua transformação em energia, e a proporção desfavorável dos preços de fertilizantes para o preço de energia, foram os principais fatores que afetaram essa economicidade

Análise preliminar da exploração florestal no Centro-sul do Brasil.

bitstream/item/215522/1/circ-tec13.pd

Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity.

Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for optimal PZAse activity. M. tuberculosis and Escherichia coli PZAses (PZAse-MT and PZAse-EC, respectively) were inactivated by metal depletion (giving PZAse-MT-Apo and PZAse-EC-Apo). Reactivation with the E. coli metallochaperone ZnuA or Rv2059 (the M. tuberculosis analog) was measured. This was repeated following proteolytic and thermal treatment of ZnuA and Rv2059. The CDC1551 M. tuberculosis reference strain had the Rv2059 coding gene knocked out, and PZA susceptibility and the pyrazinoic acid (POA) efflux rate were measured. ZnuA (200 μM) achieved 65% PZAse-EC-Apo reactivation. Rv2059 (1 μM) and ZnuA (1 μM) achieved 69% and 34.3% PZAse-MT-Apo reactivation, respectively. Proteolytic treatment of ZnuA and Rv2059 and application of three (but not one) thermal shocks to ZnuA significantly reduced the capacity to reactivate PZAse-MT-Apo. An M. tuberculosis Rv2059 knockout strain was Wayne positive and susceptible to PZA and did not have a significantly different POA efflux rate than the reference strain, although a trend toward a lower efflux rate was observed after knockout. The metallochaperone Rv2059 restored the activity of metal-depleted PZAse in vitro Although Rv2059 is important in vitro, it seems to have a smaller effect on PZA susceptibility in vivo. It may be important to mechanisms of action and resistance to pyrazinamide in M. tuberculosis Further studies are needed for confirmation.IMPORTANCE Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis and remains one of the major causes of disease and death worldwide. Pyrazinamide is a key drug used in the treatment of tuberculosis, yet its mechanism of action is not fully understood, and testing strains of M. tuberculosis for pyrazinamide resistance is not easy with the tools that are presently available. The significance of the present research is that a metallochaperone-like protein may be crucial to pyrazinamide's mechanisms of action and of resistance. This may support the development of improved tools to detect pyrazinamide resistance, which would have significant implications for the clinical management of patients with tuberculosis: drug regimens that are appropriately tailored to the resistance profile of a patient's individual strain lead to better clinical outcomes, reduced onward transmission of infection, and reduction of the development of resistant strains that are more challenging and expensive to treat

Properties of a beam splitter entangler with Gaussian input states

An explicit formula is given for the quantity of entanglement in the output state of a beam splitter, given the squeezed vacuum states input in each mode.Comment: To appear in Phys. Rev.