Making Distinct Dynamical Systems Appear Spectrally Identical

We show that a laser pulse can always be found that induces a desired optical response from an arbitrary dynamical system. As illustrations, driving fields are computed to induce the same optical response from a variety of distinct systems (open and closed, quantum and classical). As a result, the observed induced dipolar spectra without detailed information on the driving field is not sufficient to characterize atomic and molecular systems. The formulation may also be applied to design materials with specified optical characteristics. These findings reveal unexplored flexibilities of nonlinear optics.Comment: 9 pages, 5 figure

Analytic Solutions to Coherent Control of the Dirac Equation

A simple framework for Dirac spinors is developed that parametrizes admissible quantum dynamics and also analytically constructs electromagnetic fields, obeying Maxwell's equations, which yield a desired evolution. In particular, we show how to achieve dispersionless rotation and translation of wave packets. Additionally, this formalism can handle control interactions beyond electromagnetic. This work reveals unexpected flexibility of the Dirac equation for control applications, which may open new prospects for quantum technologies

Dirac open quantum system dynamics: formulations and simulations

We present an open system interaction formalism for the Dirac equation. Overcoming a complexity bottleneck of alternative formulations, our framework enables efficient numerical simulations (utilizing a typical desktop) of relativistic dynamics within the von Neumann density matrix and Wigner phase space descriptions. Employing these instruments, we gain important insights into the effect of quantum dephasing for relativistic systems in many branches of physics. In particular, the conditions for robustness of Majorana spinors against dephasing are established. Using the Klein paradox and tunneling as examples, we show that quantum dephasing does not suppress negative energy particle generation. Hence, the Klein dynamics is also robust to dephasing

Nonspreading relativistic electron wavepacket in a strong laser field

A solution of the Dirac equation in a strong laser field presenting a nonspreading wave packet in the rest frame of the electron is derived. It consists of a generalization of the self-accelerating free electron wave packet [Kaminer et al. Nature Phys. 11, 261 (2015)] to the case with the background of a strong laser field. Built upon the notion of nonspreading for an extended relativistic wavepacket, the concept of Born rigidity for accelerated motion in relativity is the key ingredient of the solution. At its core, the solution comes from the connection between the self-accelerated free electron wave packet and the eigenstate of a Dirac electron in a constant and homogeneous gravitational field via the equivalence principle. The solution is an essential step towards the realization of the laser-driven relativistic collider [Meuren et al. PRL 114, 143201 (2015)], where the large spreading of a common Gaussian wave packet during the excursion in a strong laser field strongly limits the expectable yields.Comment: 12 pages, 2 figure

Decoherence-Free Entropic Gravity for Dirac Fermion

The theory of entropic gravity conjectures that gravity emerges thermodynamically rather than being a fundamental force. One of the main criticisms of entropic gravity is that it would lead to quantum massive particles losing coherence in free fall, which is not observed experimentally. This criticism was refuted in [Phys. Rev. Res. 3, 033065 (2021)], where a nonrelativistic master equation modeling gravity as an open quantum system interaction demonstrated that in the strong coupling limit, coherence could be maintained and reproduce conventional free-fall dynamics. Moreover, the nonrelativistic master equation was shown to be fully compatible with the qBounce experiment for ultracold neutrons. Motivated by this, we extend these results to gravitationally accelerating Dirac fermions. We achieve this by using the Dirac equation in Rindler space and modeling entropic gravity as a thermal bath thus adopting the open quantum systems approach as well. We demonstrate that in the strong coupling limit, our entropic gravity model maintains quantum coherence for Dirac fermions. In addition, we demonstrate that spin is not affected by entropic gravity. We use the Foldy-Wouthysen transformation to demonstrate that it reduces to the nonrelativistic master equation, supporting the entropic gravity hypothesis for Dirac fermions. Also, we demonstrate how antigravity seemingly arises from the Dirac equation for free-falling antiparticles but use numerical simulations to show that this phenomenon originates from zitterbewegung thus not violating the equivalence principle.Comment: 23 pages and 3 figures (A note about the antigravity experiment [Nature 621, 716 (2023)] was added.

Modulatory effects of cAMP and PKC activation on gap junctional intercellular communication among thymic epithelial cells

<p>Abstract</p> <p>Background</p> <p>We investigated the effects of the signaling molecules, cyclic AMP (cAMP) and protein-kinase C (PKC), on gap junctional intercellular communication (GJIC) between thymic epithelial cells (TEC).</p> <p>Results</p> <p>Treatment with 8-Br-cAMP, a cAMP analog; or forskolin, which stimulates cAMP production, resulted in an increase in dye transfer between adjacent TEC, inducing a three-fold enhancement in the mean fluorescence of coupled cells, ascertained by flow cytometry after calcein transfer. These treatments also increased Cx43 mRNA expression, and stimulated Cx43 protein accumulation in regions of intercellular contacts. VIP, adenosine, and epinephrine which may also signal through cyclic nucleotides were tested. The first two molecules did not mimic the effects of 8-Br-cAMP, however epinephrine was able to increase GJIC suggesting that this molecule functions as an endogenous inter-TEC GJIC modulators. Stimulation of PKC by phorbol-myristate-acetate inhibited inter-TEC GJIC. Importantly, both the enhancing and the decreasing effects, respectively induced by cAMP and PKC, were observed in both mouse and human TEC preparations. Lastly, experiments using mouse thymocyte/TEC heterocellular co-cultures suggested that the presence of thymocytes does not affect the degree of inter-TEC GJIC.</p> <p>Conclusions</p> <p>Overall, our data indicate that cAMP and PKC intracellular pathways are involved in the homeostatic control of the gap junction-mediated communication in the thymic epithelium, exerting respectively a positive and negative role upon cell coupling. This control is phylogenetically conserved in the thymus, since it was seen in both mouse and human TEC preparations. Lastly, our work provides new clues for a better understanding of how the thymic epithelial network can work as a physiological syncytium.</p

Mechanisms and role of microRNA deregulation in cancer onset and progression

MicroRNAs are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis and invasion. MicroRNA targeting is mostly achieved through specific base-pairing interactions between the 5′ end (‘seed’ region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs; target sites in the 3′ UTR diminish mRNA stability. Since miRNAs frequently target hundreds of mRNAs, miRNA regulatory pathways are complex. Calin and Croce were the first to demonstrate a connection between microRNAs and increased risk of developing cancer, and meanwhile the role of microRNAs in carcinogenesis has definitively been evidenced. It needs to be considered that the complex mechanism of gene regulation by microRNAs is profoundly influenced by variation in gene sequence (polymorphisms) of the target sites. Thus, individual variability could cause patients to present differential risks regarding several diseases. Aiming to provide a critical overview of miRNA dysregulation in cancer, this article reviews the growing number of studies that have shown the importance of these small molecules and how these microRNAs can affect or be affected by genetic and epigenetic mechanisms

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin