Interacting Modified Variable Chaplygin Gas in Non-flat Universe

A unified model of dark energy and matter is presented using the modified variable Chaplygin gas for interacting dark energy in a non-flat universe. The two entities interact with each other non-gravitationally which involves a coupling constant. Due to dynamic interaction, the variation in this constant arises that henceforth changes the equations of state of these quantities. We have derived the effective equations of state corresponding to matter and dark energy in this interacting model. Moreover, the case of phantom energy is deduced by putting constraints on the parameters involved.Comment: 9 pages; Accepted for publication in European Physical Journal

A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria.

Background: Familial Hyperparathyroidism (HPT) and Familial benign Hypocalciuric Hypercalcemia (FHH) are the most common causes of hereditary hypercalcemia. FHH has been demonstrated to be caused by inactivating mutations of calcium-sensing receptor (CaSR) gene, involved in PTH regulation as well as in renal calcium excretion.Case presentation: In two individuals, father and son, we found a novel heterozygous mutation in CaSR gene. The hypercalcemia was present only in father, which, by contrast to the classic form of FHH showed hypercalciuria (from 300 to 600 mg/24 h in different evaluations) and a Calcium/Creatinine ratio of 0.031, instead of low or normal calciuria (<0.01 typical finding in FHH). His son showed the same mutation in CaSR gene, but no clinical signs or hypercalcemia although serum ionized calcium levels were close to the upper limit of normal values (1.30 mmol/L: normal range: 1.12-1.31 mmol/L). Sequence analysis revealed a point mutation at codon 972 of CaSR gene (chromosome 3q), located within cytoplasmic domain of the CaSR, that changes Threonine with Methionine. The father was treated with Cinacalcet 90 mg/day, with a decrease of total serum calcemia from an average value of 12.2 mg/dl to 10.9 mg/dl.Conclusion: This is a case of a novel inactivating point mutation of CaSR gene that determines an atypical clinical presentation of FHH, characterized by hypercalcemia, hypercalciuria and inadequate normal PTH levels. Functional assay demonstrated that the 972 M variant influenced the maturation of the protein, in terms of the post-translational glycosylation. The impairment of the receptor activity is in keeping with the specific localization of the 972 residue in the C-terminal tail, assigned to the intracellular signalling, that on the basis of the our findings appears to be differently modulated in parathyroid gland and in kidne

On the resolution of cosmic coincidence problem and phantom crossing with triple interacting fluids

We here investigate a cosmological model in which three fluids interact with each other involving certain coupling parameters and energy exchange rates. The motivation of the problem stems from the puzzling `triple coincidence problem' which naively asks why the cosmic energy densities of matter, radiation and dark energy are almost of the same order of magnitude at the present time. In our model, we determine the conditions under triple interacting fluids will cross the phantom divide.Comment: 22 pages, 6 figures, to appear in Eur. Phys. J. C (2009

Dynamics of interacting phantom and quintessence dark energies

We present models, in which phantom energy interacts with two different types of dark energies including variable modified Chaplygin gas (VMCG) and new modified Chaplygin gas (NMCG). We then construct potentials for these cases. It has been shown that the potential of the phantom field decreases from a higher value with the evolution of the Universe.Comment: 7 pages, 6 figures, accepted for publication in Astrophysics and Space Scienc

Interacting Generalised Cosmic Chaplygin gas in Loop quantum cosmology: A singularity free universe

In this work we investigate the background dynamics when dark energy is coupled to dark matter with a suitable interaction in the universe described by Loop quantum cosmology. Dark energy in the form of Generalised Cosmic Chaplygin gas is considered. A suitable interaction between dark energy and dark matter is taken into account in order to at least alleviate (if not solve) the cosmic coincidence problem. The dynamical system of equations is solved numerically and a stable scaling solution is obtained. A significant attempt towards the solution of the cosmic coincidence problem is taken. The statefinder parameters are also calculated to classify the dark energy model. Graphs and phase diagrams are drawn to study the variations of these parameters. It is seen that the background dynamics of Generalised Cosmic Chaplygin gas is completely consistent with the notion of an accelerated expansion in the late universe. From the graphs, generalised cosmic Chaplygin gas is identified as a dark fluid with a lesser negative pressure compared to Modified Chaplygin gas, thus supporting a 'No Big Rip' cosmology. It has also been shown that in this model the universe follows the power law form of expansion around the critical point, which is consistent with the known results. Future singularities that may be formed in this model as an ultimate fate of the universe has been studied in detail. It was found that the model is completely free from any types of future singularities.Comment: 10 pages, 10 figures. arXiv admin note: text overlap with arXiv:1109.1481, arXiv:1102.275

Cosmic coincidence problem and variable constants of physics

The standard model of cosmology is investigated using time dependent cosmological constant $\Lambda$ and Newton's gravitational constant $G$. The total energy content is described by the modified Chaplygin gas equation of state. It is found that the time dependent constants coupled with the modified Chaplygin gas interpolate between the earlier matter to the later dark energy dominated phase of the universe. We also achieve a convergence of parameter $\omega\to-1$, with minute fluctuations, showing an evolving $\omega$. Thus our model fairly alleviates the cosmic coincidence problem which demands $\omega=-1$ at present time.Comment: 27 pages, 15 figure

Interacting entropy-corrected new agegraphic dark energy in Brans-Dicke cosmology

Motivated by a recent work of one of us [1], we extend it by using quantum (or entropy) corrected new agegraphic dark energy in the Brans-Dicke cosmology. The correction terms are motivated from the loop quantum gravity which is one of the competitive theories of quantum gravity. Taking the non-flat background spacetime along with the conformal age of the universe as the length scale, we derive the dynamical equation of state of dark energy and the deceleration parameter. An important consequence of this study is the phantom divide scenario with entropy-corrected new agegraphic dark energy. Moreover, we assume a system of dark matter, radiation and dark energy, while the later interacts only with dark matter. We obtain some essential expressions related with dark energy dynamics. The cosmic coincidence problem is also resolved in our model.Comment: 16 pages, no figure, accepted for publication in Gen. Relativ. Gra

Interacting Kasner-type cosmologies

It is well known that Kasner-type cosmologies provide a useful framework for analyzing the three-dimensional anisotropic expansion because of the simplification of the anisotropic dynamics. In this paper relativistic multi-fluid Kasner-type scenarios are studied. We first consider the general case of a superposition of two ideal cosmic fluids, as well as the particular cases of non-interacting and interacting ones, by introducing a phenomenological coupling function $q(t)$. For two-fluid cosmological scenarios there exist only cosmological scaling solutions, while for three-fluid configurations there exist not only cosmological scaling ones, but also more general solutions. In the case of triply interacting cosmic fluids we can have energy transfer from two fluids to a third one, or energy transfer from one cosmic fluid to the other two. It is shown that by requiring the positivity of energy densities there always is a matter component which violates the dominant energy condition in this kind of anisotropic cosmological scenarios.Comment: Accepted for publication in Astrophysics &Space Science, 8 page

Reconstruction of f(T) gravity according to holographic dark energy

We develop the reconstruction of a model of $f(T)$ gravity according to the holographic dark energy. $T$ is the torsion scalar and its initial value from the Teleparallel gravity is imposed for fitting the initial value of the function $f(T)$. The result shows a polynomial function for $f(T)$, and we also observe that, when $\Omega_V\rightarrow 1$ at the future time, $\omega_V$ may cross -1 for some values of the input parameter $b$. Another interesting aspect of the obtained model is that it provides the unification of the dark matter with the dark energy.Comment: 11 pages, Accepted for publication in EPJ

Overall survival results of AGO-OVAR16: A phase 3 study of maintenance pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced ovarian cancer

OBJECTIVE: The AGO-OVAR16 study was designed to test the efficacy, safety, and tolerability of pazopanib maintenance after first-line chemotherapy in patients with newly diagnosed advanced ovarian cancer (AOC). METHODS: Nine hundred and forty patients with histologically confirmed AOC, International Federation of Gynecology and Obstetrics (FIGO) stage II-IV, were randomized in a 1:1 ratio to receive either 800 mg pazopanib once daily or placebo for up to 24 months, unless there was disease progression, toxicity, withdrawal of consent, or death. The primary endpoint (investigator-assessed progression-free survival [PFS]) was met and previously reported. The results of final analyses of overall survival (OS) are reported here. RESULTS: A third OS interim analysis showed futility and led to study closure and a final OS analysis after last patient last visit. At the time of the final OS analysis, 494 (89.7% of the planned 551) events had occurred. No difference was observed in OS between pazopanib and placebo. The hazard ratio (HR) was 0.960 (95% confidence interval [CI]: 0.805-1.145), and the median OS from randomization was 59.1 months in pazopanib and 64.0 months in placebo arms. For the East Asian patients, similar to the first three interim OS analyses, a numerical negative trend was observed favoring placebo (HR, 1.332; 95% CI: 0.863-2.054). Exploratory analyses showed a trend for a longer time to first subsequent anti-cancer therapy or death with pazopanib over placebo (HR, 0.829; 95% CI: 0.713-0.965), with a median estimate of 19.0 and 14.5 months, respectively. No new safety signals were observed. CONCLUSION: Although pazopanib prolonged PFS, this was not associated with improvement in median OS. CLINICAL TRIAL INFORMATION: ClinicalTrials.gov: NCT00866697. ispartof: Gynecol Oncol vol:155 issue:2 pages:186-191 ispartof: location:United States status: publishe