149 research outputs found
Interacting Modified Variable Chaplygin Gas in Non-flat Universe
A unified model of dark energy and matter is presented using the modified
variable Chaplygin gas for interacting dark energy in a non-flat universe. The
two entities interact with each other non-gravitationally which involves a
coupling constant. Due to dynamic interaction, the variation in this constant
arises that henceforth changes the equations of state of these quantities. We
have derived the effective equations of state corresponding to matter and dark
energy in this interacting model. Moreover, the case of phantom energy is
deduced by putting constraints on the parameters involved.Comment: 9 pages; Accepted for publication in European Physical Journal
A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria.
Background: Familial Hyperparathyroidism (HPT) and Familial benign Hypocalciuric Hypercalcemia (FHH) are the most common causes of hereditary hypercalcemia. FHH has been demonstrated to be caused by inactivating mutations of calcium-sensing receptor (CaSR) gene, involved in PTH regulation as well as in renal calcium excretion.Case presentation: In two individuals, father and son, we found a novel heterozygous mutation in CaSR gene. The hypercalcemia was present only in father, which, by contrast to the classic form of FHH showed hypercalciuria (from 300 to 600 mg/24 h in different evaluations) and a Calcium/Creatinine ratio of 0.031, instead of low or normal calciuria (<0.01 typical finding in FHH). His son showed the same mutation in CaSR gene, but no clinical signs or hypercalcemia although serum ionized calcium levels were close to the upper limit of normal values (1.30 mmol/L: normal range: 1.12-1.31 mmol/L). Sequence analysis revealed a point mutation at codon 972 of CaSR gene (chromosome 3q), located within cytoplasmic domain of the CaSR, that changes Threonine with Methionine. The father was treated with Cinacalcet 90 mg/day, with a decrease of total serum calcemia from an average value of 12.2 mg/dl to 10.9 mg/dl.Conclusion: This is a case of a novel inactivating point mutation of CaSR gene that determines an atypical clinical presentation of FHH, characterized by hypercalcemia, hypercalciuria and inadequate normal PTH levels. Functional assay demonstrated that the 972 M variant influenced the maturation of the protein, in terms of the post-translational glycosylation. The impairment of the receptor activity is in keeping with the specific localization of the 972 residue in the C-terminal tail, assigned to the intracellular signalling, that on the basis of the our findings appears to be differently modulated in parathyroid gland and in kidne
On the resolution of cosmic coincidence problem and phantom crossing with triple interacting fluids
We here investigate a cosmological model in which three fluids interact with
each other involving certain coupling parameters and energy exchange rates. The
motivation of the problem stems from the puzzling `triple coincidence problem'
which naively asks why the cosmic energy densities of matter, radiation and
dark energy are almost of the same order of magnitude at the present time. In
our model, we determine the conditions under triple interacting fluids will
cross the phantom divide.Comment: 22 pages, 6 figures, to appear in Eur. Phys. J. C (2009
Dynamics of interacting phantom and quintessence dark energies
We present models, in which phantom energy interacts with two different types
of dark energies including variable modified Chaplygin gas (VMCG) and new
modified Chaplygin gas (NMCG). We then construct potentials for these cases. It
has been shown that the potential of the phantom field decreases from a higher
value with the evolution of the Universe.Comment: 7 pages, 6 figures, accepted for publication in Astrophysics and
Space Scienc
Interacting Generalised Cosmic Chaplygin gas in Loop quantum cosmology: A singularity free universe
In this work we investigate the background dynamics when dark energy is
coupled to dark matter with a suitable interaction in the universe described by
Loop quantum cosmology. Dark energy in the form of Generalised Cosmic Chaplygin
gas is considered. A suitable interaction between dark energy and dark matter
is taken into account in order to at least alleviate (if not solve) the cosmic
coincidence problem. The dynamical system of equations is solved numerically
and a stable scaling solution is obtained. A significant attempt towards the
solution of the cosmic coincidence problem is taken. The statefinder parameters
are also calculated to classify the dark energy model. Graphs and phase
diagrams are drawn to study the variations of these parameters. It is seen that
the background dynamics of Generalised Cosmic Chaplygin gas is completely
consistent with the notion of an accelerated expansion in the late universe.
From the graphs, generalised cosmic Chaplygin gas is identified as a dark fluid
with a lesser negative pressure compared to Modified Chaplygin gas, thus
supporting a 'No Big Rip' cosmology. It has also been shown that in this model
the universe follows the power law form of expansion around the critical point,
which is consistent with the known results. Future singularities that may be
formed in this model as an ultimate fate of the universe has been studied in
detail. It was found that the model is completely free from any types of future
singularities.Comment: 10 pages, 10 figures. arXiv admin note: text overlap with
arXiv:1109.1481, arXiv:1102.275
Cosmic coincidence problem and variable constants of physics
The standard model of cosmology is investigated using time dependent
cosmological constant and Newton's gravitational constant . The
total energy content is described by the modified Chaplygin gas equation of
state. It is found that the time dependent constants coupled with the modified
Chaplygin gas interpolate between the earlier matter to the later dark energy
dominated phase of the universe. We also achieve a convergence of parameter
, with minute fluctuations, showing an evolving . Thus our
model fairly alleviates the cosmic coincidence problem which demands
at present time.Comment: 27 pages, 15 figure
Interacting entropy-corrected new agegraphic dark energy in Brans-Dicke cosmology
Motivated by a recent work of one of us [1], we extend it by using quantum
(or entropy) corrected new agegraphic dark energy in the Brans-Dicke cosmology.
The correction terms are motivated from the loop quantum gravity which is one
of the competitive theories of quantum gravity. Taking the non-flat background
spacetime along with the conformal age of the universe as the length scale, we
derive the dynamical equation of state of dark energy and the deceleration
parameter. An important consequence of this study is the phantom divide
scenario with entropy-corrected new agegraphic dark energy. Moreover, we assume
a system of dark matter, radiation and dark energy, while the later interacts
only with dark matter. We obtain some essential expressions related with dark
energy dynamics. The cosmic coincidence problem is also resolved in our model.Comment: 16 pages, no figure, accepted for publication in Gen. Relativ. Gra
Interacting Kasner-type cosmologies
It is well known that Kasner-type cosmologies provide a useful framework for
analyzing the three-dimensional anisotropic expansion because of the
simplification of the anisotropic dynamics. In this paper relativistic
multi-fluid Kasner-type scenarios are studied. We first consider the general
case of a superposition of two ideal cosmic fluids, as well as the particular
cases of non-interacting and interacting ones, by introducing a
phenomenological coupling function . For two-fluid cosmological scenarios
there exist only cosmological scaling solutions, while for three-fluid
configurations there exist not only cosmological scaling ones, but also more
general solutions. In the case of triply interacting cosmic fluids we can have
energy transfer from two fluids to a third one, or energy transfer from one
cosmic fluid to the other two. It is shown that by requiring the positivity of
energy densities there always is a matter component which violates the dominant
energy condition in this kind of anisotropic cosmological scenarios.Comment: Accepted for publication in Astrophysics &Space Science, 8 page
Reconstruction of f(T) gravity according to holographic dark energy
We develop the reconstruction of a model of gravity according to the
holographic dark energy. is the torsion scalar and its initial value from
the Teleparallel gravity is imposed for fitting the initial value of the
function . The result shows a polynomial function for , and we also
observe that, when at the future time, may
cross -1 for some values of the input parameter . Another interesting aspect
of the obtained model is that it provides the unification of the dark matter
with the dark energy.Comment: 11 pages, Accepted for publication in EPJ
Overall survival results of AGO-OVAR16: A phase 3 study of maintenance pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced ovarian cancer
OBJECTIVE: The AGO-OVAR16 study was designed to test the efficacy, safety, and tolerability of pazopanib maintenance after first-line chemotherapy in patients with newly diagnosed advanced ovarian cancer (AOC). METHODS: Nine hundred and forty patients with histologically confirmed AOC, International Federation of Gynecology and Obstetrics (FIGO) stage II-IV, were randomized in a 1:1 ratio to receive either 800 mg pazopanib once daily or placebo for up to 24 months, unless there was disease progression, toxicity, withdrawal of consent, or death. The primary endpoint (investigator-assessed progression-free survival [PFS]) was met and previously reported. The results of final analyses of overall survival (OS) are reported here. RESULTS: A third OS interim analysis showed futility and led to study closure and a final OS analysis after last patient last visit. At the time of the final OS analysis, 494 (89.7% of the planned 551) events had occurred. No difference was observed in OS between pazopanib and placebo. The hazard ratio (HR) was 0.960 (95% confidence interval [CI]: 0.805-1.145), and the median OS from randomization was 59.1 months in pazopanib and 64.0 months in placebo arms. For the East Asian patients, similar to the first three interim OS analyses, a numerical negative trend was observed favoring placebo (HR, 1.332; 95% CI: 0.863-2.054). Exploratory analyses showed a trend for a longer time to first subsequent anti-cancer therapy or death with pazopanib over placebo (HR, 0.829; 95% CI: 0.713-0.965), with a median estimate of 19.0 and 14.5 months, respectively. No new safety signals were observed. CONCLUSION: Although pazopanib prolonged PFS, this was not associated with improvement in median OS. CLINICAL TRIAL INFORMATION: ClinicalTrials.gov: NCT00866697. ispartof: Gynecol Oncol vol:155 issue:2 pages:186-191 ispartof: location:United States status: publishe
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