Cementation scenarios for New Zealand Cenozoic nontropical limestones

Cenozoic limestones are widely distributed in New Zealand, especially in the Oligocene-earliest Miocene in both islands, and the Pliocene-Pleistocene in North Island. A spectrum of limestone types exists, but all are skeletal-dominated (>70%), with usually <20% interparticle cement-matrix and <10% siliciclasts, and they have facies attributes typical of nontropical carbonates. The range of diagenetic features identified within the limestones is the basis for assigning them to a small number of “end-member” cementation classes that are inferred to be associated with four, broad, diagenetic settings

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning.

Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+ T cells, these approaches have been difficult to extend to peptides presented by MHC class II molecules that stimulate CD4+ T cells. We describe here a novel strategy for identifying CD4+ T cell-stimulating antigen genes. Using Listeria monocytogenes-specific, lacZ-inducible T cells as single-cell probes, we screened a Listeria monocytogenes genomic library as recombinant Escherichia coli that were fed to macrophages. The antigen gene was isolated from the E. coli clone that, when ingested by the macrophages, allowed generation of the appropriate peptide/MHC class II complex and T cell activation. We show that the antigenic peptide is derived from a previously unknown listeria gene product with characteristics of a membrane-bound protein

Intermittent many-body dynamics at equilibrium

The equilibrium value of an observable defines a manifold in the phase space of an ergodic and equipartitioned many-body system. A typical trajectory pierces that manifold infinitely often as time goes to infinity. We use these piercings to measure both the relaxation time of the lowest frequency eigenmode of the Fermi-Pasta-Ulam chain, as well as the fluctuations of the subsequent dynamics in equilibrium. The dynamics in equilibrium is characterized by a power-law distribution of excursion times far off equilibrium, with diverging variance. Long excursions arise from sticky dynamics close to q-breathers localized in normal mode space. Measuring the exponent allows one to predict the transition into nonergodic dynamics. We generalize our method to Klein-Gordon lattices where the sticky dynamics is due to discrete breathers localized in real space.We thank P. Jeszinszki and I. Vakulchyk for helpful discussions on computational aspects. The authors acknowledge financial support from IBS (Project Code No. IBS-R024-D1). (IBS-R024-D1 - IBS)Published versio

The use of conversation mapping to frame key perceptual issues facing the general dental practice system in England

&lt;b&gt;Objective&lt;/b&gt;: To demonstrate the use of a novel qualitative methodology namely conversation mapping, which can be used to capture differences in stakeholder perspectives and give a root definition of the problem in a complex policy area. The methodology is used in the context of the changes introduced in the English general dental practice system in April 2006, to investigate the key issues facing the system, as perceived by general dental practitioners (GDPs). &lt;b&gt;Basic research design&lt;/b&gt;: From a broad trigger statement, three transformational statements were produced. Each participant recorded their contribution on a hard diagrammatic form as a ‘map’, with others responding with their own written comment, thus generating three conversation maps. Thematic analysis resulted in the generation of a preliminary model summarising key perceptual issues. &lt;b&gt;Results&lt;/b&gt;: The five emergent themes identified were: financing, dentists’ wants/needs, the role of the public and patients, system goals and policy level decision making. Financing was identified as the core category to which all other categories were related. &lt;b&gt;Conclusions&lt;/b&gt;: Conversation mapping, a methodology arising from a systems approach, can be used to develop a ‘rich picture’ of an oral health care system in order to define the core problem within this policy area. Findings suggest that GDPs identify the financing of the system as a fundamental source of problems within the general dental practice system. This appears to be at variance with the perception of policy makers, who report a more limited view, identifying the system of remuneration as the ‘heart of the problem’

Kinetics of viral self-assembly: the role of ss RNA antenna

A big class of viruses self-assemble from a large number of identical capsid proteins with long flexible N-terminal tails and ss RNA. We study the role of the strong Coulomb interaction of positive N-terminal tails with ss RNA in the kinetics of the in vitro virus self-assembly. Capsid proteins stick to unassembled chain of ss RNA (which we call "antenna") and slide on it towards the assembly site. We show that at excess of capsid proteins such one-dimensional diffusion accelerates self-assembly more than ten times. On the other hand at excess of ss RNA, antenna slows self-assembly down. Several experiments are proposed to verify the role of ss RNA antenna.Comment: 4 pages, 3 figures, several experiments are proposed, a new idea of experiment is adde

A fluid flow perspective on the diagenesis of Te Aute limestones

Pliocene cool-water, bioclastic Te Aute limestones in East Coast Basin, New Zealand, accumulated either in shelfal shoal areas or about structurally shallow growth fold structures in the tectonically active accretionary forearc prism. Up to five stages of carbonate cementation are recognised, based on cement sequence-stratigraphic concepts, that formed on the seafloor during exposure of the limestones before burial, during burial, uplift, and deformation. Two principal fluid types are identified--topography-driven meteoric fluids and compaction-driven fluids. We have developed conceptual and quantitative models that attempt to relate the physical characteristics of fluid flow to the cement paragenesis. In particular, we have simulated the effects of uplift of the axial ranges bordering East Coast Basin in terms of the degree of penetration of a meteoric wedge into the basin. The dynamics of meteoric flow changed dramatically during uplift over the last 2 m.y. such that the modelled extent of the meteoric wedge is at least 40 km across the basin, and the penetration depth 1500 m or more corresponding with measured freshwater intersections in some oil wells. Cement-fluid relationships include: (1) true marine cements that precipitated in areas remote from shallow freshwater lenses; (2) pre-compaction cements that formed in shallow freshwater lenses beneath limestone "islands"; (3) post-compaction cements derived from compaction-driven flow during burial; (4) early uplift-related fracture-fill cements formed during deformation of the accretionary prism and uplift of the axial ranges; and (5) late uplift-related cements associated with uplift into a shallow meteoric regime

The ubiquitous 1100 charge ordering in organic charge-transfer solids

Charge and spin-orderings in the 1/4-filled organic CT solids are of strong interest, especially in view of their possible relations to organic superconductivity. We show that the charge order (CO) in both 1D and 2D CT solids is of the ...1100... type, in contradiction to mean field prediction of >...1010... CO. We present detailed computations for metal-insulator and magnetic insulator-insulator transitions in the theta-ET materials. Complete agreement with experiments in several theta systems is found. Similar comparisons between theory and experiments in TCNQ, TMTTF, TMTSF, and ET materials prove the ubiquity of this phenomenon.Comment: 3 pages, 4 eps figures; ICSM 200

Sudden Expansion of a One-Dimensional Bose Gas from Power-Law Traps

We analyze free expansion of a trapped one-dimensional Bose gas after a sudden release from the confining trap potential. By using the stationary phase and local density approximations, we show that the long-time asymptotic density profile and the momentum distribution of the gas are determined by the initial distribution of Bethe rapidities (quasimomenta) and hence can be obtained from the solutions to the Lieb-Liniger equations in the thermodynamic limit. For expansion from a harmonic trap, and in the limits of very weak and very strong interactions, we recover the self-similar scaling solutions known from the hydrodynamic approach. For all other power-law traps and arbitrary interaction strengths, the expansion is not self-similar and shows strong dependence of the density profile evolution on the trap anharmonicity. We also characterize dynamical fermionization of the expanding cloud in terms of correlation functions describing phase and density fluctuations.Comment: Final published version with modified title and a couple of other minor changes. 5 pages, 2 figures, and Supplemental Materia