11 research outputs found
Supplementary Material for: Neurodevelopmental Effects of Undernutrition and Placental Underperfusion in Fetal Growth Restriction Rabbit Models
<p><b><i>Introduction:</i></b> Chronic reduction of oxygen and nutrient
delivery to the fetus has been related to neurodevelopmental problems.
Placental underperfusion induces a significant reduction in oxygen and
nutrient delivery, whereas maternal undernutrition causes mainly
nutrient deficiency. A comparison of the neurodevelopmental effects of
both situations in pregnant rabbits was performed. <b><i>Materials and Methods:</i></b>
The placental underperfusion model was induced after uteroplacental
vessel ligation at 25 days of pregnancy. The undernutrition model was
induced after a reduction of 70% of the basal maternal intake at 22 days
of pregnancy. Neurobehavioral tests were applied in the derived
offspring at the neonatal period and over the long term. Structural
brain differences were evaluated by brain networks obtained from
diffusion magnetic resonance imaging. <b><i>Results:</i></b> Birth
weight was significantly lower in both cases. However, stillbirth was
only increased in the placental underperfusion model. Cases from both
models presented poorer neurobehavioral performance and network
infrastructure, being more pronounced in the placental underperfusion
model. <b><i>Discussion:</i></b> Prenatal insults during the last third
of gestation resulted in functional and structural disturbances. The
degree of neurodevelopmental impairment and its association with
structural brain reorganization seemed to be related to the type of the
prenatal insult, showing stronger effects in the placental
underperfusion model.</p
Predatory publishing in Scopus: evidence on cross-country differences lacks justification
Merit, Expertise and Measuremen
Predatory publishing in Scopus: evidence on cross-country differences lacks justification
Merit, Expertise and Measuremen