Urspelerpes, U. brucei

Number of Pages: 3Integrative BiologyGeological Science

Hypertension-induced renal fibrosis and spironolactone response vary by rat strain and mineralocorticoid receptor gene expression

Introduction. Aldosterone promotes renal fibrosis via the mineralocorticoid receptor (MR), thus contributing to hypertension-induced nephropathy. We investigated whether MR gene expression influences renal fibrosis and MR antagonist response in a two-kidney, one-clip hypertensive rat model. Materials and methods. Brown Norway (BN), Lewis, and ACI rats were randomised to spironolactone 20 mg/kg/day or water by gavage, starting four weeks after left renal artery clipping. Blood pressure was measured bi-weekly by tail cuff. After eight weeks of treatment, right kidneys were removed and examined for fibrosis and gene expression. Rats of each strain undergoing no intervention served as controls. Results. Blood pressure increased similarly among strains after clipping and was unaffected by spironolactone. Hypertension caused the greatest renal fibrosis in BN rats (p \u3c 0.001 by ANOVA compared to other strains). Real-time PCR analysis showed greater renal collagen type I and MR gene expression in untreated, hypertensive BN rats (both p \u3c 0.05 compared to other strains). Spironolactone attenuated fibrosis, with similar fibrosis among strains of spironolactone-treated rats. Conclusion. Hypertension-induced renal fibrosis was greatest in rats with the highest MR gene expression. Spironolactone abolished inter-strain differences in fibrosis. Our data suggest that MR genotype may influence aldosterone-induced renal damage, and consequently, renal response to aldosterone antagonism

Global Stochastic Field Simulator

This poster was featured at the 2013 Perot Museum of Nature and Science's 'Social Science' exhibit. It discusses the Global Stochastic Field Simulator, conceived in the summer of 2011

A Framework to Simulate and Visualize Epidemics

This poster was featured at the 2013 Perot Museum of Nature and Science's 'Social Science' exhibit. The poster discusses a framework to simulate and visualize epidemics

The Grizzly, October 25, 1985

Registration has Come Upon Us • RA Supervision Allows Reimert\u27s Co-ed Transition • Siblings Sharing the Same Experience • One Hundred Years of Tradition Passes With Fretz • Prof. Profile: Armstrong Balances his own Studies With Students\u27 Studies • In Search of Success: Lehman Leans Towards Stockbroker • Letters: What is That Eye Material?; Walter Still Upset; Music Comes to UC • Scram Leaves its Name in Reimert History • Concert Review: Bon Jovi and Ratt Draw a Crowd of Leather • Wanted: Attempted Murder • Bears Fall to Fifth Ranked Gettysburg • Annual Snell Game Ends in a Tie • Booters Win a Big One Over Haverford Squad • Mers Ready to Plunge Into Season • New Course at U.C.: Human Sexuality • Richter Named as Chairman • How to Handle the Effects of Harmful Stress • Roving Reporter: Do You Think Fraternities and Sororities are a Positive Aspect of Campus Life?https://digitalcommons.ursinus.edu/grizzlynews/1149/thumbnail.jp

The Grizzly, September 27, 1985

Weight Room Draws a Crowd • Why Alter the Campus Now? • C.A.B Owns a New Name • Letter: Allocate Athletic Funds • CPP and Carla Rinde Can Show the Way • Prof. Profile: Chambliss Keeps a Difficult Balance •Jeff Page: A Friendly Face in the Crowd • Staiger\u27s Home Away From Home • What\u27s Your Opinion? • Search of Success • Field Hockey Shoots to Top Ten Ranking • Bears Split Two • Cross Country Teams on Fire • Barnes: Guarding is His Game • Computer Lab Launchedhttps://digitalcommons.ursinus.edu/grizzlynews/1145/thumbnail.jp

The Grizzly, March 7, 1986

Meyer to Undergo Surgery • Teachers Always Looking to the Future: NASA Finalists Speak to Some U.C. Students • Garbage: It\u27s Expensive Stuff • Letters: CAB Responds to Only at Ursinus Comments; Student Offended by Walkman Listener at Haydn Concert • Bomberger Concerts Deserve Crowd, Too • Tie for First in Air Band • How to get that \u27A\u27 • It\u27s All in Good Fun Guys • What are You Doing Next Week? • Nuclear War as a Just War • Women\u27s Studies Offered in Fall • Mer Chicks a Success at MAC\u27s • U.C. Boys Bearing Down • Women\u27s Lacrosse Preview • Coach Brown Named Ass\u27t Athletic Director • Townshend Strikes Gold With White City LP • Tolkien Collection On Display in Myrin • Faculty Views of Pledginghttps://digitalcommons.ursinus.edu/grizzlynews/1160/thumbnail.jp

Facilitators and barriers to physical activity following pulmonary rehabilitation in COPD: a systematic review of qualitative studies

Pulmonary rehabilitation has short-term benefits on dyspnea, exercise capacity and quality of life in COPD, but evidence suggests these do not always translate to increased daily physical activity on a patient level. This is attributed to a limited understanding of the determinants of physical activity maintenance following pulmonary rehabilitation. This systematic review of qualitative research was conducted to understand COPD patients’ perceived facilitators and barriers to physical activity following pulmonary rehabilitation. Electronic databases of published data, non-published data, and trial registers were searched to identify qualitative studies (interviews, focus groups) reporting the facilitators and barriers to physical activity following pulmonary rehabilitation for people with COPD. Thematic synthesis of qualitative data was adopted involving line-by-line coding of the findings of the included studies, development of descriptive themes, and generation of analytical themes. Fourteen studies including 167 COPD patients met the inclusion criteria. Seven sub-themes were identified as influential to physical activity following pulmonary rehabilitation. These included: intentions, self-efficacy, feedback of capabilities and improvements, relationship with health care professionals, peer interaction, opportunities following pulmonary rehabilitation and routine. These encapsulated the facilitators and barriers to physical activity following pulmonary rehabilitation and were identified as sub-themes within the three analytical themes, which were beliefs, social support, and the environment. The findings highlight the challenge of promoting physical activity following pulmonary rehabilitation in COPD and provide complementary evidence to aid evaluations of interventions already attempted in this area, but also adds insight into future development of interventions targeting physical activity maintenance in COPD