Transport in the Laughlin quasiparticle interferometer: Evidence for topological protection in an anyonic qubit

We report experiments on temperature and Hall voltage bias dependence of the superperiodic conductance oscillations in the novel Laughlin quasiparticle interferometer, where quasiparticles of the 1/3 fractional quantum Hall fluid execute a closed path around an island of the 2/5 fluid. The amplitude of the oscillations fits well the quantum-coherent thermal dephasing dependence predicted for a two point-contact chiral edge channel interferometer in the full experimental temperature range 10.2<T<141 mK. The temperature dependence observed in the interferometer is clearly distinct from the behavior in single-particle resonant tunneling and Coulomb blockade devices. The 5h/e flux superperiod, originating in the anyonic statistical interaction of Laughlin quasiparticles, persists to a relatively high T~140 mK. This temperature is only an order of magnitude less than the 2/5 quantum Hall gap. Such protection of quantum logic by the topological order of fractional quantum Hall fluids is expected to facilitate fault-tolerant quantum computation with anyons.Comment: 13 pages, 10 figure

HDAC inhibitors in acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled proliferation, differentiation arrest, and accumulation of immature myeloid progenitors. Although clinical advances in AML have been made, especially in young patients, long-term disease-free survival remains poor, making this disease an unmet therapeutic challenge. Epigenetic alterations and mutations in epigenetic regulators contribute to the pathogenesis of AML, supporting the rationale for the use of epigenetic drugs in patients with AML. While hypomethylating agents have already been approved in AML, the use of other epigenetic inhibitors, such as histone deacetylases (HDAC) inhibitors (HDACi), is under clinical development. HDACi such as Panobinostat, Vorinostat, and Tricostatin A have been shown to promote cell death, autophagy, apoptosis, or growth arrest in preclinical AML models, yet these inhibitors do not seem to be effective as monotherapies, but rather in combination with other drugs. In this review, we discuss the rationale for the use of different HDACi in patients with AML, the results of preclinical studies, and the results obtained in clinical trials. Although so far the results with HDACi in clinical trials in AML have been modest, there are some encouraging data from treatment with the HDACi Pracinostat in combination with DNA demethylating agents

Analysis of Shot Noise at Finite Temperatures in Fractional Quantum Hall Edge States

We investigate shot noise at {\it finite temperatures} induced by the quasi-particle tunneling between fractional quantum Hall (FQH) edge states. The resulting Fano factor has the peak structure at a certain bias voltage. Such a structure indicates that quasi-particles are weakly {\it glued} due to thermal fluctuation. We show that the effect makes it possible to probe the difference of statistics between $\nu=1/5,{}2/5$ FQH states where quasi-particles have the same unit charge.Finally we propose a way to indirectly obtain statistical angle in hierarchical FQH states.Comment: 5 pages, 3 figure

Adding flavor to the gravity dual of non-commutative gauge theories

We study the addition of flavor degrees of freedom to the supergravity dual of the non-commutative deformation of the maximally supersymmetric gauge theories. By considering D7 flavor branes in the probe approximation and studying their fluctuations we extract the spectrum of scalar and vector mesons as a function of the non-commutativity. We find that the spectrum for very large non-commutative parameter is equal to the one in the commutative theory, while for some intermediate values of the non-commutativity some of the modes disappear from the discrete spectrum. We also study the semiclassical dynamics of rotating open strings attached to the D7-brane, which correspond to mesons with large spin. Under the effect of the non-commutativity the open strings get tilted. However, at small(large) distances they display the same Regge-like (Coulombic) behaviour as in the commutative theory. We also consider the addition of D5-flavor branes to the non-commutative deformation of the N=1 supersymmetric Maldacena-Nunez background.Comment: 50 pages, 9 figures, LaTeX; v2: minor improvements, references added; v3: typos correcte

Full Counting Statistics of Multiple Andreev Reflections in incoherent diffusive superconducting junctions

We present a theory for the full distribution of current fluctuations in incoherent diffusive superconducting junctions, subjected to a voltage bias. This theory of full counting statistics of incoherent multiple Andreev reflections is valid for arbitrary applied voltage. We present a detailed discussion of the properties of the first four cumulants as well as the low and high voltage regimes of the full counting statistics. The work is an extension of the results of Pilgram and the author, Phys. Rev. Lett. 94, 086806 (2005).Comment: Included in special issue Spin Physics of Superconducting heterostructures of Applied Physics A: Materials Science & Processin

Anyonic interferometry and protected memories in atomic spin lattices

Strongly correlated quantum systems can exhibit exotic behavior called topological order which is characterized by non-local correlations that depend on the system topology. Such systems can exhibit remarkable phenomena such as quasi-particles with anyonic statistics and have been proposed as candidates for naturally fault-tolerant quantum computation. Despite these remarkable properties, anyons have never been observed in nature directly. Here we describe how to unambiguously detect and characterize such states in recently proposed spin lattice realizations using ultra-cold atoms or molecules trapped in an optical lattice. We propose an experimentally feasible technique to access non-local degrees of freedom by performing global operations on trapped spins mediated by an optical cavity mode. We show how to reliably read and write topologically protected quantum memory using an atomic or photonic qubit. Furthermore, our technique can be used to probe statistics and dynamics of anyonic excitations.Comment: 14 pages, 6 figure

Holographic flavor on the Higgs branch

In this paper we study the holographic dual, in several spacetime dimensions, of the Higgs branch of gauge theories with fundamental matter. These theories contain defects of various codimensionalities, where the matter fields are located. In the holographic description the matter is added by considering flavor brane probes in the supergravity backgrounds generated by color branes, while the Higgs branch is obtained when the color and flavor branes recombine with each other. We show that, generically, the holographic dual of the Higgs phase is realized by means of the addition of extra flux on the flavor branes and by choosing their appropriate embedding in the background geometry. This suggests a dielectric interpretation in terms of the color branes, whose vacuum solutions precisely match the F- and D-flatness conditions obtained on the field theory side. We further compute the meson mass spectra in several cases and show that when the defect added has codimension greater than zero it becomes continuous and gapless.Comment: 59 pages, 1 figure;v2: references adde

Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity

The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would indicate that the path of evolution is biased for the relevant trait and network. Although examples of parallel evolution have implicated recurrent modification of the same gene and cis-regulatory element (CRE), little is known about the mutational and molecular paths of parallel CRE evolution. In Drosophila melanogaster fruit flies, the Bric-à-brac (Bab) transcription factors control the development of a suite of sexually dimorphic traits on the posterior abdomen. Female-specific Bab expression is regulated by the dimorphic element, a CRE that possesses direct inputs from body plan (ABD-B) and sex-determination (DSX) transcription factors. Here, we find that the recurrent evolutionary modification of this CRE underlies both intraspecific and interspecific variation in female pigmentation in the melanogaster species group. By reconstructing the sequence and regulatory activity of the ancestral Drosophila melanogaster dimorphic element, we demonstrate that a handful of mutations were sufficient to create independent CRE alleles with differing activities. Moreover, intraspecific and interspecific dimorphic element evolution proceeded with little to no alterations to the known body plan and sex-determination regulatory linkages. Collectively, our findings represent an example where the paths of evolution appear biased to a specific CRE, and drastic changes in function were accompanied by deep conservation of key regulatory linkages. © 2013 Rogers et al

Moduli Spaces of Cold Holographic Matter

We use holography to study (3+1)-dimensional N=4 supersymmetric Yang-Mills theory with gauge group SU(Nc), in the large-Nc and large-coupling limits, coupled to a single massless (n+1)-dimensional hypermultiplet in the fundamental representation of SU(Nc), with n=3,2,1. In particular, we study zero-temperature states with a nonzero baryon number charge density, which we call holographic matter. We demonstrate that a moduli space of such states exists in these theories, specifically a Higgs branch parameterized by the expectation values of scalar operators bilinear in the hypermultiplet scalars. At a generic point on the Higgs branch, the R-symmetry and gauge group are spontaneously broken to subgroups. Our holographic calculation consists of introducing a single probe Dp-brane into AdS5 times S^5, with p=2n+1=7,5,3, introducing an electric flux of the Dp-brane worldvolume U(1) gauge field, and then obtaining explicit solutions for the worldvolume fields dual to the scalar operators that parameterize the Higgs branch. In all three cases, we can express these solutions as non-singular self-dual U(1) instantons in a four-dimensional space with a metric determined by the electric flux. We speculate on the possibility that the existence of Higgs branches may point the way to a counting of the microstates producing a nonzero entropy in holographic matter. Additionally, we speculate on the possible classification of zero-temperature, nonzero-density states described holographically by probe D-branes with worldvolume electric flux.Comment: 56 pages, 8 PDF images, 4 figure

Holographic flavor in theories with eight supercharges

We review the holographic duals of gauge theories with eight supercharges obtained by adding very few flavors to pure supersymmetric Yang-Mills with sixteen supercharges. Assuming a brane-probe limit, the gravity duals are engineered in terms of probe branes (the so-called flavor brane) in the background of the color branes. Both types of branes intersect on a given subspace in which the matter is confined. The gauge theory dual is thus the corresponding flavoring of the gauge theory with sixteen supercharges. Those theories have in general a non-trivial phase structure; which is also captured in a beautiful way by the gravity dual. Along the lines of the gauge/gravity duality, we review also some of the results on the meson spectrum in the different phases of the theories.Comment: Invited review submitted to IJMP