TriHex: combining formation flying, general circular orbits and alias-free imaging, for high resolution L-band aperture synthesis

The Soil Moisture and Ocean Salinity (SMOS) mission of the European Space Agency (ESA), together with NASA’s Soil Moisture Active Passive (SMAP) mission, is providing a wealth of information to the user community for a wide range of applications. Although both missions are still operational, they have significantly exceeded their design life time. For this reason, ESA is looking at future mission concepts, which would adequately address the requirements of the passive L-band community beyond SMOS and SMAP. This article proposes one mission concept, TriHex, which has been found capable of achieving high spatial resolution, radiometric resolution, and accuracy, approaching the user needs. This is possible by the combination of aperture synthesis, formation flying, the use of general circular orbits, and alias-free imaging.Peer ReviewedPostprint (author's final draft

A machine-learning based bio-psycho-social model for the prediction of non-obstructive and obstructive coronary artery disease

Background: Mechanisms of myocardial ischemia in obstructive and non-obstructive coronary artery disease (CAD), and the interplay between clinical, functional, biological and psycho-social features, are still far to be fully elucidated. Objectives: To develop a machine-learning (ML) model for the supervised prediction of obstructive versus non-obstructive CAD. Methods: From the EVA study, we analysed adults hospitalized for IHD undergoing conventional coronary angiography (CCA). Non-obstructive CAD was defined by a stenosis < 50% in one or more vessels. Baseline clinical and psycho-socio-cultural characteristics were used for computing a Rockwood and Mitnitski frailty index, and a gender score according to GENESIS-PRAXY methodology. Serum concentration of inflammatory cytokines was measured with a multiplex flow cytometry assay. Through an XGBoost classifier combined with an explainable artificial intelligence tool (SHAP), we identified the most influential features in discriminating obstructive versus non-obstructive CAD. Results: Among the overall EVA cohort (n = 509), 311 individuals (mean age 67 ± 11 years, 38% females; 67% obstructive CAD) with complete data were analysed. The ML-based model (83% accuracy and 87% precision) showed that while obstructive CAD was associated with higher frailty index, older age and a cytokine signature characterized by IL-1β, IL-12p70 and IL-33, non-obstructive CAD was associated with a higher gender score (i.e., social characteristics traditionally ascribed to women) and with a cytokine signature characterized by IL-18, IL-8, IL-23. Conclusions: Integrating clinical, biological, and psycho-social features, we have optimized a sex- and gender-unbiased model that discriminates obstructive and non-obstructive CAD. Further mechanistic studies will shed light on the biological plausibility of these associations. Clinical trial registration: NCT02737982

The Sex-Specific Detrimental Effect of Diabetes and Gender-Related Factors on Pre-admission Medication Adherence Among Patients Hospitalized for Ischemic Heart Disease: Insights From EVA Study

Background: Sex and gender-related factors have been under-investigated as relevant determinants of health outcomes across non-communicable chronic diseases. Poor medication adherence results in adverse clinical outcomes and sex differences have been reported among patients at high cardiovascular risk, such as diabetics. The effect of diabetes and gender-related factors on medication adherence among women and men at high risk for ischemic heart disease (IHD) has not yet been fully investigated.Aim: To explore the role of sex, gender-related factors, and diabetes in pre-admission medication adherence among patients hospitalized for IHD.Materials and Methods: Data were obtained from the Endocrine Vascular disease Approach (EVA) (ClinicalTrials.gov Identifier: NCT02737982), a prospective cohort of patients admitted for IHD. We selected patients with baseline information regarding the presence of diabetes, cardiovascular risk factors, and gender-related variables (i.e., gender identity, gender role, gender relations, institutionalized gender). Our primary outcome was the proportion of pre-admission medication adherence defined through a self-reported questionnaire. We performed a sex-stratified analysis of clinical and gender-related factors associated with pre-admission medication adherence.Results: Two-hundred eighty patients admitted for IHD (35% women, mean age 70), were included. Around one-fourth of the patients were low-adherent to therapy before hospitalization, regardless of sex. Low-adherent patients were more likely diabetic (40%) and employed (40%). Sex-stratified analysis showed that low-adherent men were more likely to be employed (58 vs. 33%) and not primary earners (73 vs. 54%), with more masculine traits of personality, as compared with medium-high adherent men. Interestingly, women reporting medication low-adherence were similar for clinical and gender-related factors to those with medium-high adherence, except for diabetes (42 vs. 20%, p = 0.004). In a multivariate adjusted model only employed status was associated with poor medication adherence (OR 0.55, 95%CI 0.31–0.97). However, in the sex-stratified analysis, diabetes was independently associated with medication adherence only in women (OR 0.36; 95%CI 0.13–0.96), whereas a higher masculine BSRI was the only factor associated with medication adherence in men (OR 0.59, 95%CI 0.35–0.99).Conclusion: Pre-admission medication adherence is common in patients hospitalized for IHD, regardless of sex. However, patient-related factors such as diabetes, employment, and personality traits are associated with adherence in a sex-specific manner

Design of optimal low-thrust manoeuvres for remote sensing multi-satellite formation flying in low Earth orbit

This paper presents a strategy for optimal manoeuvre design of multi-satellite formation flying in low Earth orbit environment, with the aim of providing a tool for mission operation design. The proposed methodology for formation flying manoeuvres foresees a continuous low-thrust control profile, to enable the operational phases. The design is performed starting from the dynamic representation described in the relative orbital elements, including the main orbital perturbations effects. It also exploits an interface with the classical radial-transversal-normal description to include the maximum delta-v limitation and the safety condition requirements. The methodology is applied to a remote sensing mission study, Formation Flying L-band Aperture Synthesis, for land and ocean application, such as a potential high-resolution Soil Moisture and Ocean Salinity (SMOS) follow-on mission, as part of a European Space Agency mission concept study. Moreover, the results are applicable to a wide range of low Earth orbit missions, exploiting a distributed system, and in particular to Formation Flying L-band Aperture Synthesis (FFLAS) as a follow-on concept to SMOS

Manoeuvre planning algorithm for satellite formations using mean relative orbital elements

Formation flying missions have increased their importance thanks to the better performances that can be achieved with a distributed system of satellites. One of the most demanding challenges linked to formation flying missions is the formulation of a robust control plan. Due to the recent developments in electrical propulsion, controllers that apply a continuous low-thrust to each spacecraft in the formation have been proposed, achieving precise control. This idea is used in this manuscript, where an open-loop manoeuvre planning algorithm is developed, to provide the control accelerations to achieve a formation reconfiguration in a given temporal frame. The proposed algorithm is based on an innovative control technique, which relies on the mean relative orbital elements as state variables of a first-order dynamic system. It includes the effect of the gravitational field of the Earth. Finally, the algorithm is tested with two different test cases of formation flying reconfiguration, presenting and analysing their results. The test case scenarios considered are based on possible future mission concepts in Low Earth Orbit, aiming at improving the control performances for the mission design

Effect of Citrate on the Size and the Magnetic Properties of Primary Fe3O4 Nanoparticles and Their Aggregates

The size, size distribution and magnetic properties of magnetite nanoparticles (NPs) prepared by co-precipitation without citrate, in the presence of citrate and citrate adsorbed postsynthesis were studied by X-ray Diffraction (XRD), Dynamic Light Scattering (DLS), Electron Paramagnetic Resonance (EPR) and magnetization measurements. The aim of this investigation was to clarify the effect of citrate ions on the size and magnetic properties of magnetite NPs. The size of the primary NPs, as determined by analysing the width of diffraction peaks using various methods, was ca. 10 nm for bare magnetite NPs and with citrate adsorbed post-synthesis, whereas it was around 5 nm for the NPs co-precipitated in the presence of citrate. DLS measurements show that the three types of NPs form aggregates (100–200 nm in diameter) but the dispersions of the citrate-coated NPs are more stable against sedimentation than those of bare NPs. The sizes and size distributions determined by XRD are in good agreement with those of the magnetic domains obtained by fitting of the magnetization vs. magnetic field intensity curves. Magnetization vs. magnetic field intensity curves show that the three kinds of sample are superparamagnetic