Very-large-scale motions in rough-bed open-channel flow

Acknowledgements The study has been supported by two EPSRC/UK grants, ‘High-resolution numerical and experimental studies of turbulence-induced sediment erosion and near-bed transport’ (EP/G056404/1) and ‘Bed friction in rough-bed free-surface flows: a theoretical framework, roughness regimes, and quantification’ (EP/K041169/1). Discussions with I. Marusic and comments of three anonymous reviewers are greatly appreciated.Peer reviewedPublisher PD

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity

Phosphodiesterase (PDE) inhibitors are currently under evaluation as agents that may facilitate the improvement of cognitive impairment associated with Alzheimer's disease. Our aim was to determine whether inhibitors of PDEs 4,5 and 9 could alleviate the cytotoxic effects of amyloid beta 1–42 (Aβ1-42) via a mechanism involving the small heatshock protein HSP20. We show that inhibition of PDEs 4,5 and 9 but not 3 induces the phosphorylation of HSP20 which, in turn, increases the co-localisation between the chaperone and Aβ1-42 to significantly decrease the toxic effect of the peptide. We conclude that inhibition of PDE9 is most effective to combat Aβ1-42 cytotoxicity in our cell model

Using Self Organizing Maps to Analyze Demographics and Swing State Voting in the 2008 U.S. Presidential Election

Emergent self-organizing maps (ESOMs) and k-means clustering are used to cluster counties in each of the states of Florida, Pennsylvania, and Ohio by demographic data from the 2010 United States census. The counties in these clusters are then analyzed for how they voted in the 2008 U.S. Presidential election, and political strategies are discussed that target demographically similar geographical regions based on ESOM results. The ESOM and k-means clusterings are compared and found to be dissimilar by the variation of information distance function

Magnetic Structure of Rapidly Rotating FK Comae-Type Coronae

We present a three-dimensional simulation of the corona of an FK Com-type rapidly rotating G giant using a magnetohydrodynamic model that was originally developed for the solar corona in order to capture the more realistic, non-potential coronal structure. We drive the simulation with surface maps for the radial magnetic field obtained from a stellar dynamo model of the FK Com system. This enables us to obtain the coronal structure for different field topologies representing different periods of time. We find that the corona of such an FK Com-like star, including the large scale coronal loops, is dominated by a strong toroidal component of the magnetic field. This is a result of part of the field being dragged by the radial outflow, while the other part remains attached to the rapidly rotating stellar surface. This tangling of the magnetic field,in addition to a reduction in the radial flow component, leads to a flattening of the gas density profile with distance in the inner part of the corona. The three-dimensional simulation provides a global view of the coronal structure. Some aspects of the results, such as the toroidal wrapping of the magnetic field, should also be applicable to coronae on fast rotators in general, which our study shows can be considerably different from the well-studied and well-observed solar corona. Studying the global structure of such coronae should also lead to a better understanding of their related stellar processes, such as flares and coronal mass ejections, and in particular, should lead to an improved understanding of mass and angular momentum loss from such systems.Comment: Accepted to ApJ, 10 pages, 6 figure

The Sun is less active than other solar-like stars

Magnetic activity of the Sun and other stars causes their brightness to vary. We investigate how typical the Sun's variability is compared to other solar-like stars, i.e. those with near-solar effective temperatures and rotation periods. By combining four years of photometric observations from the Kepler space telescope with astrometric data from the Gaia spacecraft, we measure photometric variabilities of 369 solar-like stars. Most of the solar-like stars with well-determined rotation periods show higher variability than the Sun and are therefore considerably more active. These stars appear nearly identical to the Sun, except for their higher variability. Their existence raises the question of whether the Sun can also experience epochs of such high variability.Comment: Accepted for publication in Science. 3 (main) + 10 (supplementary) figure

Utility of a routine ultrasound for detection of ectopic pregnancies among women requesting abortion:A retrospective review

INTRODUCTION: Routine ultrasound may be used in abortion services to determine gestational age and confirm an intrauterine pregnancy. However, ultrasound adds complexity to care and results may be inconclusive, delaying abortion. We sought to determine the rate of ectopic pregnancy and the utility of routine ultrasound in its detection, in a community abortion service. METHODS: Retrospective case record review of women requesting abortion over a 5-year period (2015–2019) with an outcome of ectopic pregnancy or pregnancy of unknown location (PUL) at a service (Edinburgh, UK) conducting routine ultrasound on all women. Records were searched for symptoms at presentation, development of symptoms during clinical care, significant risk factors and routine ultrasound findings. RESULTS: Only 29/11 381 women (0.25%, 95% CI 0.18%, 0.33%) had an ectopic pregnancy or PUL (tubal=18, caesarean scar=1, heterotopic=1, PUL=9). Eleven (38%) cases had either symptoms at presentation (n=8) and/or significant risk factors for ectopic pregnancy (n=4). A further 12 women developed symptoms during their clinical care. Of the remaining six, three were PUL treated with methotrexate and three were ectopic (salpingectomy=2, methotrexate=1). In three cases, the baseline ultrasound indicated a probable early intrauterine pregnancy. CONCLUSIONS: Ectopic pregnancies are uncommon among women presenting for abortion. The value of routine ultrasound in excluding ectopic pregnancy in symptom-free women without significant risk factors is questionable as it may aid detection of some cases but may provide false reassurance that a pregnancy is intrauterine

Measurement of Orbital Decay in the Double Neutron Star Binary PSR B2127+11C

We report the direct measurement of orbital period decay in the double neutron star pulsar system PSR B2127+11C in the globular cluster M15 at the rate of $(-3.95 \pm 0.13) \times 10^{-12}$, consistent with the prediction of general relativity at the $\sim 3$ level. We find the pulsar mass to be $m_p = (1.358 \pm 0.010) M_\odot$ and the companion mass $m_c = (1.354 \pm 0.010) M_\odot$. We also report long-term pulse timing results for the pulsars PSR B2127+11A and PSR B2127+11B, including confirmation of the cluster proper motion.Comment: 12 pages, 4 figures, accepted for publication in ApJ