Effects of upper extremity aerobic exercise training on functional exercise capacity in patients with pulmonary arterial hypertension

Pulmoner arteriyel hipertansiyon (PAH) pulmoner arter basıncındaki artış ile karakterize nadir görülen, kronik ve ilerleyici bir kardiyopulmoner hastalıktır. Çalışmanın amacı PAH'lı hastalarda üst ekstremite aerobik egzersiz eğitiminin egzersiz kapasitesi, solunum fonksiyonları, solunum ve periferik kas kuvveti, fiziksel aktivite seviyesi, dispne, yorgunluk, depresyon ve yaşam kalitesi üzerine etkisinin araştırılmasıydı. Çalışma rastgellenmiş, kontrollü, ileriye dönük, çift kör planlandı. Eğitim grubundaki (EG) 11 hastaya 15-45 dk/gün, 3 gün/6 hafta üst ekstremite aerobik egzersiz eğitimi (maks.KH'nın %50-80'i) uygulandı. Kontrol grubundaki (KG) 11 hastaya 6 hafta boyunca alternatif kol hareketleri ve solunum egzersizleri verildi. Fonksiyonel egzersiz kapasitesi, solunum fonksiyonları, solunum ve periferik kas kuvveti, dispne, yorgunluk, fiziksel aktivite seviyesi, yaşam kalitesi ve depresyon seviyesi egzersiz eğitimi öncesi ve sonrasında değerlendirildi. Her iki grubun başlangıç özellikleri benzerdi (p>0,05). EG'de inspiratuar kas kuvveti (p=0,008), dispne (p0,05). Inspiratory muscle strength (p=0,008), dyspnea (p<0,001), pulmonary function (p=0,012), peak oxygen consumption (p=0,049), shoulder abductors muscle strength (p<0,001), fatigue severity (p=0,050) were significantly improved in AET group compared to controls. Respiratory muscle strength, dyspnea, functional exercise capacity, shoulder abductors muscle strength, peak oxygen consumption, minute ventilation, tidal volume, end tidal carbondioxide pressure, fatigue severity and vitality, social functioning and role physical were significantly improved within AET group (p<0,05). Quadriceps femoris muscle strength and oxygen consumption at aeaerobic threshold were significantly decreased in CG (p<0,05). In conclusion upper extremity aerobic exercise training improves exercise capacity, respiratory and peripheral muscle strength, pulmonary function and quality of life, decreases dyspnea and fatigue perception. Upper extremity aerobic exercise training is a safe and effective intervention in patients with PAH

Effects of Inspiratory Muscle Training in Subjects With Sarcoidosis: A Randomized Controlled Clinical Trial.

Respiratory muscle weakness occurs in sarcoidosis and is related to decreased exercise capacity, greater fatigue, dyspnea, and lower quality of life in sarcoidosis patients. The effects of inspiratory muscle training in this population have not been comprehensively investigated so far. This study was planned to investigate the effects of inspiratory muscle training on exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life in subjects with sarcoidosis

The Role of Inspiratory Muscle Training in Sickle Cell Anemia Related Pulmonary Damage due to Recurrent Acute Chest Syndrome Attacks.

Background. The sickling of red blood cells causes a constellation of musculoskeletal, cardiovascular, and pulmonary manifestations. A 32-year-old gentleman with sickle cell anemia (SCA) had been suffering from recurrent acute chest syndrome (ACS). Aim. To examine the effects of inspiratory muscle training (IMT) on pulmonary functions, respiratory and peripheral muscle strength, functional exercise capacity, and quality of life in this patient with SCA. Methods. Functional exercise capacity was evaluated using six-minute walk test, respiratory muscle strength using mouth pressure device, hand grip strength using hand-held dynamometer, pain using Visual Analogue Scale, fatigue using Fatigue Severity Scale, dyspnea using Modified Medical Research Council Scale, and health related quality of life using European Organization for Research and Treatment of Cancer QOL measurement. Results. A significant improvement has been demonstrated in respiratory muscle strength, functional exercise capacity, pain, fatigue, dyspnea, and quality of life. There was no admission to emergency department due to acute chest syndrome in the following 12 months after commencing regular erythrocytapheresis. Conclusion. This is the first report demonstrating the beneficial effects of inspiratory muscle training on functional exercise capacity, respiratory muscle strength, pain, fatigue, dyspnea, and quality of life in a patient with recurrent ACS